ID B0WVG8_CULQU Unreviewed; 853 AA.
AC B0WVG8;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=GPI ethanolamine phosphate transferase 2 {ECO:0000256|ARBA:ARBA00020830};
GN Name=6043789 {ECO:0000313|EnsemblMetazoa:CPIJ010890-PA};
GN ORFNames=CpipJ_CPIJ010890 {ECO:0000313|EMBL:EDS35574.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS35574.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS35574.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ010890-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ010890-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
CC {ECO:0000256|ARBA:ARBA00005315}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS232126; EDS35574.1; -; Genomic_DNA.
DR RefSeq; XP_001861390.1; XM_001861355.1.
DR AlphaFoldDB; B0WVG8; -.
DR STRING; 7176.B0WVG8; -.
DR EnsemblMetazoa; CPIJ010890-RA; CPIJ010890-PA; CPIJ010890.
DR KEGG; cqu:CpipJ_CPIJ010890; -.
DR VEuPathDB; VectorBase:CPIJ010890; -.
DR VEuPathDB; VectorBase:CQUJHB003139; -.
DR VEuPathDB; VectorBase:CQUJHB012294; -.
DR eggNOG; KOG2125; Eukaryota.
DR HOGENOM; CLU_004770_4_0_1; -.
DR InParanoid; B0WVG8; -.
DR OMA; DEFCISA; -.
DR OrthoDB; 5479199at2759; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd16024; GPI_EPT_2; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 2.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037674; PIG-G_N.
DR InterPro; IPR039527; PIGG/GPI7.
DR InterPro; IPR045687; PIGG/GPI7_C.
DR PANTHER; PTHR23072:SF0; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2; 1.
DR PANTHER; PTHR23072; PHOSPHATIDYLINOSITOL GLYCAN-RELATED; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF19316; PIGO_PIGG; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 9..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 521..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 639..656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 522..678
FT /note="GPI ethanolamine phosphate transferase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19316"
SQ SEQUENCE 853 AA; 97288 MW; F9691D017D60BCA1 CRC64;
MIVQVRHVSI YLFSVFICSI SLFCYGFFPL SFSPSTKSAP SDLPGSMDSL RLDPDGYKPR
NSRAVLMVID ALRTDFVAQR DNMRFLNELL ANGSACQYQL QVHPPTVTMP RIKAITSGAI
PSFLDVILNL GSPEMKLDTF LYQMHLKQRG LVFYGDITWT RMFPGLFARQ GENVDSLYVN
DFYEGDKNIT KKMRLEFGNY DWKMMILHFL GLDHIGHVEG PFSDKIPGKL QEMDNVIKEI
YGAMIKWNEK YYTKPLLVIT GDHGMRDSGG HGGSTYPETH VPLLVVGNSC RKSDELFLQI
DLAPTFATLM GVVIPHSSIG SLIDPMFNDV PSVDRVYAAH YNTRRLIEKA QEFYKDNLKE
QDFYVQYKEA KLLHAMFLEH RDDLVILDKV LSKYAAISKH LSRMLIRNYI RYDMLSIVIG
IALSVMTTIL AVLLMIIPHT SEQVEIKPKL FIWMTIAGIA FLAKILLKKY SITESSLLQS
TYINHILLVS LSSLTTIHYS LLTGLLPLLN RTNWLKQPRG LPSYLLLFGS CFHTLSLAAS
SFIEEEHQTL YYFTNTLFLL LTLTEIRIMN ATIAQVDQVA KSSNEVLLEH CRRERDEFCI
SAGLFFVGHI VLRRFNQTGD KWQHLPDIGD WLGRDGNRVW LSVVLAVGLC YLLVALARFS
GFLTIVLSAT SCLLVYYYRL MTGVVGLFGV APSNAVESAL GSTARVGKQH WFEKKAAYAV
KLRAATHKNV AQYKQALKQQ RTVNKLKKRQ LKDRDRAEME QLFRQNETRK FYEKVDRSRK
GYAPQANTCR DAEGNLLMDK GEFQPDLETV KINRAAGKDR LPCELFKYEG EQLPRAIHSV
ISKIWEEEKL PEE
//
