ID B0WWN0_CULQU Unreviewed; 1106 AA.
AC B0WWN0;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase 7 {ECO:0000256|ARBA:ARBA00021393};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
DE AltName: Full=Ubiquitin thioesterase 7 {ECO:0000256|ARBA:ARBA00031508};
DE AltName: Full=Ubiquitin-specific-processing protease 7 {ECO:0000256|ARBA:ARBA00031500};
GN Name=6044263 {ECO:0000313|EnsemblMetazoa:CPIJ010988-PA};
GN ORFNames=CpipJ_CPIJ010988 {ECO:0000313|EMBL:EDS36122.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS36122.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS36122.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ010988-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ010988-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
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DR EMBL; DS232149; EDS36122.1; -; Genomic_DNA.
DR RefSeq; XP_001861802.1; XM_001861767.1.
DR AlphaFoldDB; B0WWN0; -.
DR STRING; 7176.B0WWN0; -.
DR MEROPS; C19.A52; -.
DR EnsemblMetazoa; CPIJ010988-RA; CPIJ010988-PA; CPIJ010988.
DR KEGG; cqu:CpipJ_CPIJ010988; -.
DR VEuPathDB; VectorBase:CPIJ010988; -.
DR VEuPathDB; VectorBase:CQUJHB003468; -.
DR eggNOG; KOG1863; Eukaryota.
DR HOGENOM; CLU_003532_0_0_1; -.
DR InParanoid; B0WWN0; -.
DR OMA; QFLPCET; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR024729; USP7_ICP0-binding_dom.
DR InterPro; IPR029346; USP_C.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF644; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7; 1.
DR Pfam; PF00917; MATH; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF14533; USP7_C2; 1.
DR Pfam; PF12436; USP7_ICP0_bdg; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EDS36122.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 65..193
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT DOMAIN 212..518
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 28..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1106 AA; 127804 MW; EAD73E495C618760 CRC64;
MDYDKTVEAM DTQDDNELDP PNVQALAPTT VVNPANGGGG GAVTAGPEQM NMDDQDNLDD
EVRSEATFSF KVENLSKLTD SVLSQAYYVR NLPWKIMAMR RTNDTTSPPS KGLGFFLQCN
GESDTANWSC SASAELRLLS VIPNRDPFVR KIRHVFSRVE NDWGFSFFMN WNDILNPENG
YIQNDAITLE VHVTAEPPRG IFWDSKKHTG YVGLKNQGAT CYMNSLLQTL YFTNQLRKAV
YKMPTEADDD CKSVALALQR VFHDLQTQSK PVGTKKLTKS FGWDALDSFM QHDVQEFLRV
LLDKLENKMK GTSLEGTIPK LFEGKMISYI KCQNVDYTSR RTETFYDIQL NIKGKKNINE
SFKDYIATEI LDDDNKYDAG EHGLQKAEKG ILFSKFPPVL HLHLMRFQYD PITDSSVKFN
DRFEFDEKIN LDPFLEKPED TSATYILHAV LVHSGDNHGG HYVVYINPKN DGKWCKFDDD
VVSRCTRNEA IEQNYGGHDN DLNIRHSSNA YMLVYVREST IHEVLEDVKS TDISDELQER
LDEQRRIQQC RRTERTEATN FMNINVLLED YMEIYQKSDL FDPATATYRT FKVRKSTTIS
ELAGMFSKAF KVEPDKMRMW TVSKNGLRIH KFQLIDANTN ETCSKYGYQD PKNSWTIFLE
MASPETNQLK PIEQNDLLIF FKSYDPAEKR LNYCGHGFFK TFRFLSDEYF QEECRKRAHY
EPDTEIRLYE VTDINKAVKM QEFFVIDSAL SLPINGSIII IEKVSAGEVE SYEFPTCEEY
LKDLYCRIEV LFVDTLNPND SGFTLDLSSE SNYEQIAKAC GRRINVDPYE IQFFKCKNFS
EIPGQPLPHN YSGTLKDILC YTKAKTVRKL FYQKLSISIN ELENKKQFRC LYLMPNLKEE
KELILYPNKN GTVASLLAEA AKVIEFHENS TKVLRISELS KNRLAPGPAK DTPLDQLHDY
TDNTFVQRTT ISNQKMYRIE EVAEDELNPA ENEMLVPVLH FTKDIGSIFG IPFFIRTVHQ
ETFATLKERM KKKLNVSDKE WEKYKLAIIT EHIDYIDDET IEINLEMFKP DLADPNSRTY
LGLEHINKNT KRSRFSNMEK AIKIYN
//
