ID B0X221_CULQU Unreviewed; 605 AA.
AC B0X221;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=alpha-glucosidase {ECO:0000256|ARBA:ARBA00012741};
DE EC=3.2.1.20 {ECO:0000256|ARBA:ARBA00012741};
GN Name=6046506 {ECO:0000313|EnsemblMetazoa:CPIJ013171-PA};
GN ORFNames=CpipJ_CPIJ013171 {ECO:0000313|EMBL:EDS38951.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS38951.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS38951.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ013171-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ013171-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-
CC glucose residues with release of alpha-D-glucose.; EC=3.2.1.20;
CC Evidence={ECO:0000256|ARBA:ARBA00001657};
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DR EMBL; DS232277; EDS38951.1; -; Genomic_DNA.
DR RefSeq; XP_001863693.1; XM_001863658.1.
DR AlphaFoldDB; B0X221; -.
DR STRING; 7176.B0X221; -.
DR EnsemblMetazoa; CPIJ013171-RA; CPIJ013171-PA; CPIJ013171.
DR KEGG; cqu:CpipJ_CPIJ013171; -.
DR VEuPathDB; VectorBase:CPIJ013171; -.
DR VEuPathDB; VectorBase:CQUJHB001939; -.
DR eggNOG; KOG0471; Eukaryota.
DR HOGENOM; CLU_006462_2_3_1; -.
DR InParanoid; B0X221; -.
DR OMA; VFEWREI; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd11328; AmyAc_maltase; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR006047; Glyco_hydro_13_cat_dom.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR045857; O16G_dom_2.
DR PANTHER; PTHR10357; ALPHA-AMYLASE FAMILY MEMBER; 1.
DR PANTHER; PTHR10357:SF235; ALPHA-GLUCOSIDASE; 1.
DR Pfam; PF00128; Alpha-amylase; 1.
DR SMART; SM00642; Aamy; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..605
FT /note="alpha-glucosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011409083"
FT TRANSMEM 577..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..434
FT /note="Glycosyl hydrolase family 13 catalytic"
FT /evidence="ECO:0000259|SMART:SM00642"
SQ SEQUENCE 605 AA; 69438 MW; 35FE992AD97D7495 CRC64;
MKRVQVLFWL GLLVAVVSAK TTGREEDGHD HDLPELDWWE GGVFYQIYPR SFKDSNGDGT
GDIKGILEKL DHLVDLGVTG VWFSPLFKSP MKDFGYDISD FLDVDPTFGT MKDLEDLLAK
AKQLGIKVIL DFVPNHTSDE HEWFVKSKSG DPDFRDFYVW KDGKAGGLPP NNWQSVFHTD
AWTKPEGSTQ FYLHQFDKGQ PDLNYENPKV KEEMKKMIEF WFSKGVDGFR IDAINHAYED
ERFLDEPLID ENRELFYENM DHKYTMNQDK SYSLIYDWRE LFDKWSVETK QTKLMMTEAY
ANLEQTMRWY GDGTRKGSHF PFNFAMINRV TNSSGAAQLK EVIDEWLDTM PKGANANWVL
GNHDRPRIAS RFGRERAASF AVLELTLPGI AVVYYGEEIG MEDYRDISFE DTQDPQAANT
NKEIYQLYSR DPVRTPFQWD SSAYAGFTAA TTVKTWLPVH SNFKELNLAA QKTAPKSIFK
LYQQLIKLRS DHTFMYGDFE SKALINNVFG YTRKLAEHKT YAVVVNMNSA DVQLNMKNLE
KDTQKLKVVV STPESKFEEN QEITDVENMI LESFDAVVFE VVTAGSSALV GSVLLLLGAV
LRALM
//
