ID B0X832_CULQU Unreviewed; 626 AA.
AC B0X832;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Ionotropic glutamate receptor C-terminal domain-containing protein {ECO:0000259|Pfam:PF00060};
GN Name=6048968 {ECO:0000313|EnsemblMetazoa:CPIJ014667-PA};
GN ORFNames=CpipJ_CPIJ014667 {ECO:0000313|EMBL:EDS42301.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS42301.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS42301.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ014667-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ014667-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; DS232472; EDS42301.1; -; Genomic_DNA.
DR RefSeq; XP_001865804.1; XM_001865769.1.
DR AlphaFoldDB; B0X832; -.
DR EnsemblMetazoa; CPIJ014667-RA; CPIJ014667-PA; CPIJ014667.
DR GeneID; 6048968; -.
DR KEGG; cqu:CpipJ_CPIJ014667; -.
DR VEuPathDB; VectorBase:CPIJ014667; -.
DR VEuPathDB; VectorBase:CQUJHB010052; -.
DR eggNOG; KOG1052; Eukaryota.
DR HOGENOM; CLU_028770_0_0_1; -.
DR InParanoid; B0X832; -.
DR OMA; SGCFSMR; -.
DR OrthoDB; 3028817at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0050906; P:detection of stimulus involved in sensory perception; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR42643:SF16; IONOTROPIC RECEPTOR 11A-RELATED; 1.
DR PANTHER; PTHR42643; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..626
FT /note="Ionotropic glutamate receptor C-terminal domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014567227"
FT TRANSMEM 339..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 341..595
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00060"
SQ SEQUENCE 626 AA; 71747 MW; 5558EC9DD16B92AB CRC64;
MSSLTVILYL AAVLDSSVPQ RLKDLAFPQD DLEEAVESVL SEYFVSNHSA VIILRSARTG
FDLEQLHSDI LDRVMAQTST SIAFMFPTTS GLSQRPCFYN LLLIDGYLAF QTVIKQIDPD
RNEFGGRFLF VMTSADRVEK VTLHSMFSTL WSNNIVNVLV ITKQYGEILM YSYFPYSADH
CEYTEPVLVD RWDSGQGNVN LFPNKLANLY GCPMRIASFD YPPFTMIARN SCSGKIHLIG
YEGFLIDTIA RKFNFSVELV VPEGNPQWGV IENNTALSGA FKMIVNLEVN LSVGGYSVRE
ERVALMEPSV TYHVVSLMLA VPPGRPYTAF EKLFRPFTLI TWLMIALYLL LGCLCIVVLR
FYPNSIRNFT YGRRTGSPLI NMLNSFFGGA LVRTPARNFA RTLLFLWMYY SFVMRSLYTG
SLYEFLQQNK TFSHISSIKH LESEGIPYLI SDTFKAFLTA YPQVLRRTQT LEDNPPAEIF
HNLKRGRLNA AVLATHDYIA WYNERYFREG VVHLADDVLL QQPICLYFPK RNCLTHPVNL
QIENIKVSGL LGYWMHQYVG YRFYKRTKRT QKAPNHQHSP KVLTNEHLAG CYQALVWLLA
LSAGIFALEL ASTRFHWLRM VFERIE
//
