UniProt: B0XA97

Database: UniProt
Entry: B0XA97_CULQU

LinkDB:  B0XA97_CULQU 
Original site:  B0XA97_CULQU

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (6)   
   InterPro (3)   
   Pfam (2)   
   SMART (1)   
All databases (14)   

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ID   B0XA97_CULQU            Unreviewed;       325 AA.
AC   B0XA97;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 93.
DE   RecName: Full=sphingolipid 4-desaturase {ECO:0000256|ARBA:ARBA00012021};
DE            EC=1.14.19.17 {ECO:0000256|ARBA:ARBA00012021};
GN   Name=6049879 {ECO:0000313|EnsemblMetazoa:CPIJ016440-PA};
GN   ORFNames=CpipJ_CPIJ016440 {ECO:0000313|EMBL:EDS43594.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS43594.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS43594.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ016440-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ016440-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family. DEGS
CC       subfamily. {ECO:0000256|ARBA:ARBA00006146,
CC       ECO:0000256|PIRNR:PIRNR017228}.
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DR   EMBL; DS232572; EDS43594.1; -; Genomic_DNA.
DR   RefSeq; XP_001866569.1; XM_001866534.1.
DR   AlphaFoldDB; B0XA97; -.
DR   STRING; 7176.B0XA97; -.
DR   EnsemblMetazoa; CPIJ016440-RA; CPIJ016440-PA; CPIJ016440.
DR   GeneID; 6049879; -.
DR   KEGG; cqu:CpipJ_CPIJ016440; -.
DR   VEuPathDB; VectorBase:CPIJ016440; -.
DR   VEuPathDB; VectorBase:CQUJHB002164; -.
DR   eggNOG; KOG2987; Eukaryota.
DR   HOGENOM; CLU_032156_0_0_1; -.
DR   InParanoid; B0XA97; -.
DR   OMA; MLANHEI; -.
DR   OrthoDB; 5485164at2759; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042284; F:sphingolipid delta-4 desaturase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030148; P:sphingolipid biosynthetic process; IEA:InterPro.
DR   CDD; cd03508; Delta4-sphingolipid-FADS-like; 1.
DR   InterPro; IPR011388; DES1/DES2.
DR   InterPro; IPR005804; FA_desaturase_dom.
DR   InterPro; IPR013866; Sphingolipid_d4-desaturase_N.
DR   PANTHER; PTHR12879; SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2; 1.
DR   PANTHER; PTHR12879:SF8; SPHINGOLIPID DELTA(4)-DESATURASE DES1; 1.
DR   Pfam; PF00487; FA_desaturase; 1.
DR   Pfam; PF08557; Lipid_DES; 1.
DR   PIRSF; PIRSF017228; Sphnglp_dlt4_des; 1.
DR   SMART; SM01269; Lipid_DES; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW   ECO:0000256|PIRNR:PIRNR017228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR017228};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|PIRNR:PIRNR017228};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        68..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        108..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        150..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        210..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          5..43
FT                   /note="Sphingolipid delta4-desaturase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01269"
SQ   SEQUENCE   325 AA;  37748 MW;  DFE15A740614D6B2 CRC64;
     MGQHVSRTDF EWVYNEQPHI GRRDVMLKKY PEIKKLYGPD PKFKYIVTAM VLMQIFMLQV
     MQDQSWKMIV LVAYCFGGVI NHSLMLANHE ISHNIAFGYG RPLANRYFGM WCNLPIGFPM
     SVSFKKYHIL HHRHLADEHL DPDVPSILEA KLFCTTLGKF IWVVLQPLFY AIRPLFVNPL
     PVERLEVINT IVQLAFNTAV VYLFGWKAMF YLIIGSLLAM GLHPVAGHFI AEHYMYAKGF
     ETYSYYGPLN WITFNVGYHN EHHDFPAIPG SRLPEVRKIA PEFYDTIPQH TSWVRVLYDF
     VMDPAIGPYA RIKRRSVEKA SKGES
//

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