ID   B0XAA1_CULQU            Unreviewed;       584 AA.
AC   B0XAA1;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   RecName: Full=alpha-glucosidase {ECO:0000256|ARBA:ARBA00012741};
DE            EC=3.2.1.20 {ECO:0000256|ARBA:ARBA00012741};
GN   Name=6049882 {ECO:0000313|EnsemblMetazoa:CPIJ016362-PA};
GN   ORFNames=CpipJ_CPIJ016362 {ECO:0000313|EMBL:EDS43598.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS43598.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS43598.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ016362-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ016362-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-
CC         glucose residues with release of alpha-D-glucose.; EC=3.2.1.20;
CC         Evidence={ECO:0000256|ARBA:ARBA00001657};
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DR   EMBL; DS232574; EDS43598.1; -; Genomic_DNA.
DR   RefSeq; XP_001866573.1; XM_001866538.1.
DR   AlphaFoldDB; B0XAA1; -.
DR   STRING; 7176.B0XAA1; -.
DR   EnsemblMetazoa; CPIJ016362-RA; CPIJ016362-PA; CPIJ016362.
DR   GeneID; 6049882; -.
DR   KEGG; cqu:CpipJ_CPIJ016362; -.
DR   VEuPathDB; VectorBase:CPIJ016362; -.
DR   VEuPathDB; VectorBase:CQUJHB018109; -.
DR   eggNOG; KOG0471; Eukaryota.
DR   HOGENOM; CLU_006462_8_3_1; -.
DR   InParanoid; B0XAA1; -.
DR   OMA; FYQIHPE; -.
DR   OrthoDB; 3680211at2759; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd11328; AmyAc_maltase; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR006047; Glyco_hydro_13_cat_dom.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR045857; O16G_dom_2.
DR   PANTHER; PTHR10357; ALPHA-AMYLASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR10357:SF233; MALTASE A1; 1.
DR   Pfam; PF00128; Alpha-amylase; 1.
DR   SMART; SM00642; Aamy; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..584
FT                   /note="alpha-glucosidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5011409167"
FT   DOMAIN          30..426
FT                   /note="Glycosyl hydrolase family 13 catalytic"
FT                   /evidence="ECO:0000259|SMART:SM00642"
SQ   SEQUENCE   584 AA;  66675 MW;  8C10D00105266C25 CRC64;
     MKTFAPLLAT LLLAGFGSAL QWWEHGNFYQ VYPRSFKDSD GNGIGDLDGV TEKLQYLKDV
     GMDGIWLSPI FASPMADFGY DISDFYNIQG EYGDLAAFER LSAKCKELGL RLILDFVPNH
     TSNQHEYFKK SVQKEDPYTN YYVWHPGVTN EDGTKSPPSN WISVFRGSAW EWNEDRQEYY
     LHQFLKEQPD LNYRDPALVE EMKNVLKFWL NKGVSGFRID AVPYLFESVE VENRYVDEPL
     SRATDDAENP AYLIHNQTMD QPETYDMIYQ WRAVLDEFTA KDNQTRIMMT EGYTSIPNVM
     KFFGEGEQNG AQIPFNFQMI SNLRKTSTAA DFARYANLWL DNLPAGRRSN WVLGNHDNNR
     IGSRLGEAKI DLYNIALQTL PDIAVTYYGE EIGMVDQPIP FNETVDPAGL RAGPDDYTLY
     SRDPARTPMQ WNSDKNAGFS SADKTWLPVA TNYKQLNVKA QDAAQKSHLK LFKRLTTYRK
     RQILTHGDLD LRTTDSNLVL YKRKVDKVGY VVVVLNFSDE PQSLAAIKQQ FPGADDRLQV
     VASSKLVTIK DNKWINVADT ELPGESAIVL QKLWGPNPVV VYEA
//