ID B0XB33_CULQU Unreviewed; 1353 AA.
AC B0XB33;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Toll {ECO:0000313|EMBL:EDS44003.1};
GN ORFNames=CpipJ_CPIJ016598 {ECO:0000313|EMBL:EDS44003.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS44003.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS44003.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; DS232609; EDS44003.1; -; Genomic_DNA.
DR RefSeq; XP_001866855.1; XM_001866820.1.
DR STRING; 7176.B0XB33; -.
DR GeneID; 6050211; -.
DR KEGG; cqu:CpipJ_CPIJ016598; -.
DR VEuPathDB; VectorBase:CPIJ016598; -.
DR VEuPathDB; VectorBase:CQUJHB014137; -.
DR eggNOG; KOG4641; Eukaryota.
DR HOGENOM; CLU_004280_0_0_1; -.
DR InParanoid; B0XB33; -.
DR OMA; WSCRCKF; -.
DR OrthoDB; 927694at2759; -.
DR PhylomeDB; B0XB33; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 7.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24366:SF152; GH22922P-RELATED; 1.
DR PANTHER; PTHR24366; IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF13676; TIR_2; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 7.
DR SMART; SM00365; LRR_SD22; 8.
DR SMART; SM00369; LRR_TYP; 21.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 9.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1040..1063
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1089..1226
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1276..1304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1333..1353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1353 AA; 152697 MW; 12D243E66F70B0C3 CRC64;
MIFSAEFSPK YRARGPSGAA TTRDGGHRSN QPETGPEPKP NTIPPFHADS HSRAELAAQS
LPSDHCQFKE ENTQEMEHLR TLVVLGALLT VAFGSQCNWE YEKASVTCRL RTIERTGLDL
QGAEGASRLD VQCSELILFE SQLPVQNSFV RLASLSELKI EACKLLQLPE GAFDGLLGLK
KLSVNTRNYE WGAGKVLELQ SASMQGLKEL QSLDLSDNNI RGLPEGFLCP LTNLKVLNLT
NNRIRATESL GLAGKTCSGG SEVQTLNLSY NEIMKIPENW GVSRLRRLQH LNLEYNNITE
LHGEALAGLS SLRTLNLSYN HLETLPAGLL AGSRELREIH LQGNQLYELP RGLFHRLEQL
LVLDLSRNQL SSHHVDNGTF SGLIRLVVLN LAHNALTRID SKTFKELYFL QILDLRNNSI
GYIEDNAFLP LYNLHTLNLA ENRLHTLDDR LFNGLYVLSK LTLNNNLISI VERNVFKNCS
DLKELDLSSN QLSEVPHAIR DLSVLRALDL GENQINYIEN GTFSNLNQLT GLRMIDNQIE
NITIGMFTDL PRLSVLNLAK NRVQNIERGS FDKNLDIEAI RLDGNFLTDI NGIFATLSSL
LWLNLAENHL VWFDYAFIPS NLKWLDIHGN YIESLGNYYK LQEEIKVKTL DASHNRLTDI
GPMNVPNSVE LLFINDNHIS TIHANTFIDK INLARVDLYA NSLKKLQLHQ LRVAPQPADK
PLPEFYLGGN PFECDCSMEW MQRVNNLTAR QHPKIMDLPN VECIMPHARG SPVRPIVSLK
PKDFLCKYET HCFALCHCCD FDACDCEMTC PTNCTCYHDQ TWGTNVVDCG NQRAALAKPV
PMDATEVYMD GNDYPELQNH AFIGRKNLKV LFANASKIIT IQNRTFAGLT ALQVLHLEDN
AIQKIHGYEF ENLGLLKELY LQNNMISVIA NNSFAPLYSL QVLRIDGNRL TTIPMAQLQA
TQLQSLQALS LGRNYWSCRC RFMQELTSFV ADNAVIIQDM QDIYCVDDGI HRDLDFNVTA
SCSDYYAGSS VLPDRLSETY IFLLAAALII ACLLVFVLVM FIFREPLRFW LFSRYGVRVF
GPRCEDSEKL YDAIFIYSAK DAEYVARNIA AELENGRPPL RLCLQHRDLS EDASHLQLLE
ASRASRRIVM LLSRNFLQTE WSRCELRRAV HDALRGRPHK LVVLEEVGVL LEAENDVELV
PYLKTATVNR IKRSDRHFWE KLRYALPVEA PYRGNNYTID HHERVKQTSG ANGPAGVMFR
QAPPAYCPEI DEANYSSATT ATPSPRPSRR GMVELPQRPP SEHIYSSIDS DYSTLECENM
VPGVHRPSST WRPGGGGGQN TMPHGHHVQA YLV
//
