ID B0XEX7_CULQU Unreviewed; 683 AA.
AC B0XEX7;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 89.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN Name=6051835 {ECO:0000313|EnsemblMetazoa:CPIJ017821-PA};
GN ORFNames=CpipJ_CPIJ017821 {ECO:0000313|EMBL:EDS26308.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS26308.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS26308.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ017821-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ017821-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00104}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS232879; EDS26308.1; -; Genomic_DNA.
DR RefSeq; XP_001868199.1; XM_001868164.1.
DR AlphaFoldDB; B0XEX7; -.
DR STRING; 7176.B0XEX7; -.
DR EnsemblMetazoa; CPIJ017821-RA; CPIJ017821-PA; CPIJ017821.
DR KEGG; cqu:CpipJ_CPIJ017821; -.
DR VEuPathDB; VectorBase:CPIJ017821; -.
DR VEuPathDB; VectorBase:CQUJHB002797; -.
DR VEuPathDB; VectorBase:CQUJHB003681; -.
DR eggNOG; KOG0940; Eukaryota.
DR HOGENOM; CLU_402943_0_0_1; -.
DR InParanoid; B0XEX7; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 2.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 2.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR PANTHER; PTHR11254:SF320; HECT-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR Pfam; PF00632; HECT; 2.
DR SMART; SM00119; HECTc; 2.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 2.
DR PROSITE; PS50237; HECT; 2.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:EDS26308.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 157..327
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT DOMAIN 346..683
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 651
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 683 AA; 79028 MW; A8401673EBF3DEA9 CRC64;
MSRYVYVKGG DISHNDYYDD GGVEADVCHS TGILYKNRQE LVSSSTSFSS LWTDMKERPS
MAIISVPEWW PCLFENEIMS YIPVEARSPQ GSPNLNNTSR VPQRAPPPFR RDFEAKLRTF
YRKLESKGFG QGPHKLKLHI RRSHLLEDAF RRIMSANKKD LQRGRLAVLW DTEEGLDYGG
PSREFFFLLS RELFNPYYGL FEYSANDTYT VQVSPLSAFV DNSHDWFRFS GRVLGLALVH
QYLLDAFFTR PFYKALLRLP VALSDLESLD NEFHQSLQWI RDNDIGSGVS LGLTFCVTEE
LLGRVVEREL KPGGKNIPVT EKNKRELHIR RSHLLEDAFR RIMSANKKDL QRGRLAVLWD
TEEGLDYGGP SREFFFLLSR ELFNPYYGLF EYSANDTYTV QVSPLSAFVD NSHDWFRFSG
RVLGLALVHQ YLLDAFFTRP FYKALLRLPV ALSDLESLDN EFHQSLQWIR DNDIGSGVSL
GLTFCVTEEL LGRVVERELK PGGKNIPVTE KNKREYLERM VKWRLERGVQ EQTESLVRGF
YEVVDPRLVS VFDARELELV IAGTAEIDLN DWRINTEYRS GYHDGHQVIV WFWHVIEKFS
NEQRLRLLQF VTGTSSIPYE GFAALRGSTG PRRFCIEKWG KPNALPRAHT CFNRLDLPPY
PTPDILYEKL LLAVEETNTF GIE
//