GenomeNet

Database: UniProt
Entry: B0XEX7_CULQU
LinkDB: B0XEX7_CULQU
Original site: B0XEX7_CULQU 
ID   B0XEX7_CULQU            Unreviewed;       683 AA.
AC   B0XEX7;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   24-JAN-2024, entry version 89.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   Name=6051835 {ECO:0000313|EnsemblMetazoa:CPIJ017821-PA};
GN   ORFNames=CpipJ_CPIJ017821 {ECO:0000313|EMBL:EDS26308.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS26308.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS26308.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ017821-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ017821-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00104}.
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DR   EMBL; DS232879; EDS26308.1; -; Genomic_DNA.
DR   RefSeq; XP_001868199.1; XM_001868164.1.
DR   AlphaFoldDB; B0XEX7; -.
DR   STRING; 7176.B0XEX7; -.
DR   EnsemblMetazoa; CPIJ017821-RA; CPIJ017821-PA; CPIJ017821.
DR   KEGG; cqu:CpipJ_CPIJ017821; -.
DR   VEuPathDB; VectorBase:CPIJ017821; -.
DR   VEuPathDB; VectorBase:CQUJHB002797; -.
DR   VEuPathDB; VectorBase:CQUJHB003681; -.
DR   eggNOG; KOG0940; Eukaryota.
DR   HOGENOM; CLU_402943_0_0_1; -.
DR   InParanoid; B0XEX7; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 2.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 2.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR   PANTHER; PTHR11254:SF320; HECT-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR   Pfam; PF00632; HECT; 2.
DR   SMART; SM00119; HECTc; 2.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 2.
DR   PROSITE; PS50237; HECT; 2.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:EDS26308.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          157..327
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   DOMAIN          346..683
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   ACT_SITE        651
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   683 AA;  79028 MW;  A8401673EBF3DEA9 CRC64;
     MSRYVYVKGG DISHNDYYDD GGVEADVCHS TGILYKNRQE LVSSSTSFSS LWTDMKERPS
     MAIISVPEWW PCLFENEIMS YIPVEARSPQ GSPNLNNTSR VPQRAPPPFR RDFEAKLRTF
     YRKLESKGFG QGPHKLKLHI RRSHLLEDAF RRIMSANKKD LQRGRLAVLW DTEEGLDYGG
     PSREFFFLLS RELFNPYYGL FEYSANDTYT VQVSPLSAFV DNSHDWFRFS GRVLGLALVH
     QYLLDAFFTR PFYKALLRLP VALSDLESLD NEFHQSLQWI RDNDIGSGVS LGLTFCVTEE
     LLGRVVEREL KPGGKNIPVT EKNKRELHIR RSHLLEDAFR RIMSANKKDL QRGRLAVLWD
     TEEGLDYGGP SREFFFLLSR ELFNPYYGLF EYSANDTYTV QVSPLSAFVD NSHDWFRFSG
     RVLGLALVHQ YLLDAFFTRP FYKALLRLPV ALSDLESLDN EFHQSLQWIR DNDIGSGVSL
     GLTFCVTEEL LGRVVERELK PGGKNIPVTE KNKREYLERM VKWRLERGVQ EQTESLVRGF
     YEVVDPRLVS VFDARELELV IAGTAEIDLN DWRINTEYRS GYHDGHQVIV WFWHVIEKFS
     NEQRLRLLQF VTGTSSIPYE GFAALRGSTG PRRFCIEKWG KPNALPRAHT CFNRLDLPPY
     PTPDILYEKL LLAVEETNTF GIE
//
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