ID B0XGC2_CULQU Unreviewed; 554 AA.
AC B0XGC2;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=5' nucleotidase {ECO:0000313|EMBL:EDS27504.1};
GN Name=6052421 {ECO:0000313|EnsemblMetazoa:CPIJ018313-PA};
GN ORFNames=CpipJ_CPIJ018313 {ECO:0000313|EMBL:EDS27504.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS27504.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS27504.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ018313-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ018313-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 5'-nucleotidase family.
CC {ECO:0000256|ARBA:ARBA00006654, ECO:0000256|RuleBase:RU362119}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS233012; EDS27504.1; -; Genomic_DNA.
DR RefSeq; XP_001868694.1; XM_001868659.1.
DR AlphaFoldDB; B0XGC2; -.
DR STRING; 7176.B0XGC2; -.
DR EnsemblMetazoa; CPIJ018313-RA; CPIJ018313-PA; CPIJ018313.
DR KEGG; cqu:CpipJ_CPIJ018313; -.
DR VEuPathDB; VectorBase:CPIJ018313; -.
DR VEuPathDB; VectorBase:CQUJHB007057; -.
DR eggNOG; KOG4419; Eukaryota.
DR HOGENOM; CLU_005854_7_1_1; -.
DR InParanoid; B0XGC2; -.
DR OMA; LDMGNEP; -.
DR OrthoDB; 4608413at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008252; F:nucleotidase activity; IEA:UniProt.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0009166; P:nucleotide catabolic process; IEA:InterPro.
DR CDD; cd07409; MPP_CD73_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.90.780.10; 5'-Nucleotidase, C-terminal domain; 1.
DR InterPro; IPR008334; 5'-Nucleotdase_C.
DR InterPro; IPR036907; 5'-Nucleotdase_C_sf.
DR InterPro; IPR006146; 5'-Nucleotdase_CS.
DR InterPro; IPR006179; 5_nucleotidase/apyrase.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR PANTHER; PTHR11575:SF24; 5'-NUCLEOTIDASE; 1.
DR PANTHER; PTHR11575; 5'-NUCLEOTIDASE-RELATED; 1.
DR Pfam; PF02872; 5_nucleotid_C; 1.
DR Pfam; PF00149; Metallophos; 1.
DR PRINTS; PR01607; APYRASEFAMLY.
DR SUPFAM; SSF55816; 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR PROSITE; PS00785; 5_NUCLEOTIDASE_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362119};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362119};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Signal {ECO:0000256|RuleBase:RU362119}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|RuleBase:RU362119"
FT CHAIN 21..554
FT /evidence="ECO:0000256|RuleBase:RU362119"
FT /id="PRO_5011325996"
FT DOMAIN 28..242
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 344..515
FT /note="5'-Nucleotidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02872"
SQ SEQUENCE 554 AA; 60788 MW; 9A81150FFC2CCA24 CRC64;
MRLFVLLGLV ALVLVGTARG QGNLYELSIV HINDFHARFE EVNAASVSCN REGGDTCVGG
YARTMTVLKK LLAERNNPLY FNAGDNFQGT LWYNIHRWNA TVEFLNMLPA DAMTIGNHEF
DHGVEGVVPF LNNINSPVLL ANVDNSEEPE FNKFQKSMMI ERNGRKIGII GVILKTTDNI
ANTGKLKFSD ESETVKAEAE LLKQQGANII IVLSHCGLDV DEIIAANAGP DIDIIVGGHS
HTFLYTGDHP DIPGTSQGEY PTVVTQQGGH KVLIVQAAAY TKFVGDIVLF FDEAGIIQRW
SGNPYYLGAD VVPVILQIGR VYPEVVQALI PWKVAVDEQG NRRVGSAAVD LLKSSCNYAE
CNLGSFIADS MAAAFVPLAE PGHWTYAAIA VVAVGGIRVS MFRGDLNFKS LIEVIPFENS
LVCVELRGDH LLGVMEYAVE KSWDEDRFNG ANMLQVSGLR VEYNVTKPIG ERVLALEVLC
ADCMVPRYEQ LQPLKYYRVV TNSFIAGGGD GFSIFPQHGR NKRIGPVDIQ AFEDYAKIRS
PIVQGIDGRI KVHT
//