ID B0XL42_CULQU Unreviewed; 785 AA.
AC B0XL42;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=6054456 {ECO:0000313|EnsemblMetazoa:CPIJ020047-PA};
GN ORFNames=CpipJ_CPIJ020047 {ECO:0000313|EMBL:EDS33336.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS33336.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS33336.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ020047-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ020047-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the peptidase C64 family.
CC {ECO:0000256|ARBA:ARBA00005865}.
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DR EMBL; DS234233; EDS33336.1; -; Genomic_DNA.
DR RefSeq; XP_001870364.1; XM_001870329.1.
DR AlphaFoldDB; B0XL42; -.
DR STRING; 7176.B0XL42; -.
DR EnsemblMetazoa; CPIJ020047-RA; CPIJ020047-PA; CPIJ020047.
DR KEGG; cqu:CpipJ_CPIJ020047; -.
DR VEuPathDB; VectorBase:CPIJ020047; -.
DR VEuPathDB; VectorBase:CQUJHB017781; -.
DR eggNOG; KOG4345; Eukaryota.
DR HOGENOM; CLU_013263_1_1_1; -.
DR InParanoid; B0XL42; -.
DR OMA; FCESEWA; -.
DR OrthoDB; 2909231at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0043170; P:macromolecule metabolic process; IEA:UniProt.
DR GO; GO:1901564; P:organonitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd22768; OTU_OTUD7; 1.
DR Gene3D; 4.10.240.30; -; 2.
DR InterPro; IPR003323; OTU_dom.
DR InterPro; IPR002653; Znf_A20.
DR PANTHER; PTHR13367:SF27; OTU DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13367; UBIQUITIN THIOESTERASE; 1.
DR Pfam; PF02338; OTU; 1.
DR Pfam; PF01754; zf-A20; 1.
DR SMART; SM00259; ZnF_A20; 2.
DR PROSITE; PS50802; OTU; 1.
DR PROSITE; PS51036; ZF_A20; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 75..276
FT /note="OTU"
FT /evidence="ECO:0000259|PROSITE:PS50802"
FT DOMAIN 753..785
FT /note="A20-type"
FT /evidence="ECO:0000259|PROSITE:PS51036"
FT REGION 160..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..706
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 785 AA; 87421 MW; 8063A9D9F8183328 CRC64;
MDFHSPLSGC AEQNAKNLNF IDTPDYTFTL PDLTKYSDDF RKFLEKDLIE SSTLNSLEAT
NRLNWWYDSG VCRKLWPLAT TGDGNCLLHA ASLAMWGFHD RRLTLRRTLH DILSKEEFRD
ALYRRWRFQQ TRLNRQAGFV FCESEWAREW EEIVAIASPE PRRNSKSGQQ GSGAGAASRR
RSLLIEKSMD GGEGGDENAA TYESLEEIHV LALAHILRRT IIVVSDVFLR DMNGEAFSPI
PFGGVYLPFE VPSNECHRAP LLLAYDMAHF SALVAMETAG DFPPALIPLV DASNQLLPIQ
FCIDPGRDFD WREYDGADGN WVLTDREHVA LLKEYLDIVY APATADSPDG DPDTYDDYSD
EEYEKRLADG EFVFADENHN SGTNLAAMTA SNQSLPPTSS SGKSKAAKQL QSVAKQFGSI
GKSMSKKLKK NIGSITRIGS KSGSHKKPNV TANKDREYPK FRILCATLKA RRHEYQEEMI
KNYLECAQER YLELERSKER RELDKLSKYV DSGHDMTDYG SEPPTTDLVN CINAGCLNYG
TVATSYMCLE CYETQKKRET INVTDFTPRY GTGKSKFYAQ ADMESHDRIQ RLPSVRRLNE
LDQTLYLSHS TFYNDQRAAM ISNAQSLQSS SNYRHGFSPT DRTKNGHHSP PNYSTCAKLA
TATSGGIVAT VYSPGNTILN RGPPSGGMCV SLPPPSLSPQ PPTPQLPSAS SSSGMSSSSS
SGSNTSETLL RQQQQQVNLA PSGAGGATTS SHYGKSQMCR TEGCKFYGSI NTNFYCSKCC
QEYNI
//
