ID B0YNB1_9MOLU Unreviewed; 568 AA.
AC B0YNB1;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 08-NOV-2023, entry version 77.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
DE Flags: Fragment;
GN Name=gyrB {ECO:0000313|EMBL:ABW84388.1};
OS Spiroplasma eriocheiris CCTCC M 207170.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC Spiroplasma.
OX NCBI_TaxID=743698 {ECO:0000313|EMBL:ABW84388.1};
RN [1] {ECO:0000313|EMBL:ABW84388.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CRAB {ECO:0000313|EMBL:ABW84388.1};
RA Bi K.R., Gu W., Wang W., Huang H., Wang J.H.;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABW84388.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CRAB {ECO:0000313|EMBL:ABW84388.1};
RX PubMed=18621053; DOI=10.1016/j.jip.2008.06.008;
RA Bi K., Huang H., Gu W., Wang J., Wang W.;
RT "Phylogenetic analysis of Spiroplasmas from three freshwater crustaceans
RT (Eriocheir sinensis, Procambarus clarkia and Penaeus vannamei) in China.";
RL J. Invertebr. Pathol. 99:57-65(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; EU014291; ABW84388.1; -; Genomic_DNA.
DR AlphaFoldDB; B0YNB1; -.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd16928; HATPase_GyrB-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.670; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR002288; DNA_gyrase_B_C.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR001241; Topo_IIA.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR000565; Topo_IIA_B.
DR InterPro; IPR013759; Topo_IIA_B_C.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR InterPro; IPR018522; TopoIIA_CS.
DR InterPro; IPR006171; TOPRIM_domain.
DR PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR PANTHER; PTHR45866:SF12; DNA TOPOISOMERASE 4 SUBUNIT B; 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR Pfam; PF00986; DNA_gyraseB_C; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR01159; DNAGYRASEB.
DR PRINTS; PR00418; TPI2FAMILY.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00433; TOP2c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR PROSITE; PS00177; TOPOISOMERASE_II; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ABW84388.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 399..513
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABW84388.1"
FT NON_TER 568
FT /evidence="ECO:0000313|EMBL:ABW84388.1"
SQ SEQUENCE 568 AA; 63176 MW; 89010E6719559D32 CRC64;
KRPGMYIGST DIRGLHHLVW EIVDNSIDEA LAGFASEINI IIHKNNGITV KDNGRGVPIG
KHASGKSTPE VIFSVLHAGG KFGGDGYKTS GGLHGVGSSV VNALSSEFDV TIYRDKKISN
IKFNNGGKLA QKLTTIGSTA TTGTTVYFVP DPEIFKVIDF SFSTISERIR ESAFLNSGLK
ITLQDERTDK YVEYLFNNGL EEFITYMNEG KKPITPIITF KGIEKDIDVE IALQYSTEFN
ENLLSFANNV KTSDGGSHVV GFRTGLTKVI NEYARKEGLL KEKDKNLDST DTREGLTAII
SVKIPESLIQ YEGQTKGKLG TSDAKTAVEN IVAKQMQFWM LENKTNAYAI IEKALLARTA
KEEARKAREA ARGNKRKSNS ERLLTGKLTP AQNKNKKVNE LFLVEGDSAG GSAKSGRDRK
FQAILSLRGK VINAEKAKLQ DLMNNEEINL MIHAIGAGFG NNFDLEDANY GKIIIMTDAD
TDGAHIQTLL LTFFYRFMRP LIEDKRVYIA LPPLFKITNL KTKKVSYAWD ENELKTKLKH
LKDKFELQRY KGLGEMNAEQ LWETTMDP
//
