ID B0Z3Y7_GIBMO Unreviewed; 492 AA.
AC B0Z3Y7;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
OS Gibberella moniliformis (Maize ear and stalk rot fungus) (Fusarium
OS verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=117187 {ECO:0000313|EMBL:ABY89285.1};
RN [1] {ECO:0000313|EMBL:ABY89285.1}
RP NUCLEOTIDE SEQUENCE.
RA Bluhm B., Kim H., Butchko R., Woloshuk C.;
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABY89285.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18705852; AGRICOLA=IND44018687;
RX DOI=10.1111/j.1364-3703.2007.00458.x;
RA Bluhm B.H., Kim H., Butchko R.A.E., Woloshuk C.P.;
RT "Involvement of ZFR1 of Fusarium verticillioides in kernel colonization and
RT the regulation of FST1, a putative sugar transporter gene required for
RT fumonisin biosynthesis on maize kernels.";
RL Mol. Plant Pathol. 9:203-211(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16126;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004888}.
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}.
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DR EMBL; EU247513; ABY89285.1; -; Genomic_DNA.
DR AlphaFoldDB; B0Z3Y7; -.
DR OMA; ADCVQQF; -.
DR UniPathway; UPA00109; UER00180.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008865; F:fructokinase activity; IEA:RHEA.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 1.10.287.1250; -; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.40.367.20; -; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR019807; Hexokinase_BS.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF16; HEXOKINASE TYPE 1-RELATED; 1.
DR Pfam; PF00349; Hexokinase_1; 1.
DR Pfam; PF03727; Hexokinase_2; 1.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS00378; HEXOKINASE_1; 1.
DR PROSITE; PS51748; HEXOKINASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU362007};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362007};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}.
FT DOMAIN 27..222
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 228..472
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
SQ SEQUENCE 492 AA; 54648 MW; AFEB1074922B2ADA CRC64;
MVGLGPRRPP SRKGSMADVP KDLADEIHKL EKLFTVEPAK LKEITDHFVS ELAKGLSVEG
GSIPMNPTWV MSYPDGYETG TYLALDMGGT NLRVCQITLT EEKSEFDILQ SKYRMPEELK
SGTSEELWEY IAECLYQFLE THHGDCSKLE KIPLGFTFSY PATQNYIDEG ILQRWTKGFD
IDGVEGKNIV PMFEEALKAR GVPIKLAAII NDTTGTLIAS AYTDTAMKIG CIFGTGCNAA
YMEDCGSIPK IADLNLPADL PMAINCEWGA FDNEHKVLPR TAYDVTIDKE SPRPGQQAFE
KMIAGLYLGE IFRLILVDLH DNKAIHIFEN QDISLLRKPY SLDASFLSAI EEDPWENLTE
TYDLFVKKLN LKPTRPELEL VRRTAELIGT RAARLSACGV AAICKKKGYE SCHVGADGSV
FNKYPYFKER GAQALREILD WPEKTDKKAE DPIEVLTAED GSGVGAALIA ALTLKRINEG
NMAGILHPEN FK
//
