ID B0ZS85_9PICO Unreviewed; 2249 AA.
AC B0ZS85;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
OS Duck hepatitis A virus 1.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Paavivirinae; Avihepatovirus;
OC Avihepatovirus A.
OX NCBI_TaxID=1006061 {ECO:0000313|EMBL:ABZ79229.1, ECO:0000313|Proteomes:UP000116841};
RN [1] {ECO:0000313|EMBL:ABZ79229.1, ECO:0000313|Proteomes:UP000116841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Ma X.L., Yu K.X., Song M.X., Huang B., Li Y.F., Wu J., Lin S.Q.;
RT "Determination of the whole genome of Duck hepatitis virus isolates from
RT China.";
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Host cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004295}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004295}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004295}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; EU395440; ABZ79229.1; -; mRNA.
DR Proteomes; UP000116841; Genome.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044162; C:host cell cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039618; C:T=pseudo3 icosahedral viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0051259; P:protein complex oligomerization; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR GO; GO:0039707; P:virus-mediated pore formation in host cell membrane; IEA:UniProtKB-KW.
DR CDD; cd23193; ps-ssRNA_Picornaviridae; 1.
DR CDD; cd00205; rhv_like; 2.
DR Gene3D; 1.20.960.20; -; 1.
DR Gene3D; 2.60.120.20; -; 2.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR006703; G_AIG1.
DR InterPro; IPR045058; GIMA/IAN/Toc.
DR InterPro; IPR004004; Helic/Pol/Pept_Calicivir-typ.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR044067; PCV_3C_PRO.
DR InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR029053; Viral_coat.
DR PANTHER; PTHR10903:SF135; GTP-BINDING PROTEIN A; 1.
DR PANTHER; PTHR10903; GTPASE, IMAP FAMILY MEMBER-RELATED; 1.
DR Pfam; PF04548; AIG1; 1.
DR Pfam; PF00548; Peptidase_C3; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00073; Rhv; 2.
DR Pfam; PF00910; RNA_helicase; 1.
DR PRINTS; PR00918; CALICVIRUSNS.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 3.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51874; PCV_3C_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00022488};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW T=pseudo3 icosahedral capsid protein {ECO:0000256|ARBA:ARBA00022706};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral ion channel {ECO:0000256|ARBA:ARBA00023039};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022706};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 1270..1432
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 1610..1795
FT /note="Peptidase C3"
FT /evidence="ECO:0000259|PROSITE:PS51874"
FT DOMAIN 2014..2129
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT REGION 250..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2249 AA; 252839 MW; 07C14D23C0D7DB14 CRC64;
MDTLTKNIED ATVNIIGSCA EKVEEAISGL GVVESVASTN SAITTANATT TQTIPDPTEG
STDDFYSCSY EVGAQGDNIS RLVHLVTGQW VPNDDYYACL RWLATPACFF QNNTQPAYGQ
TRYFRFIRCG FHFRLLVNAP SGSAGALMLV WVPYPYCRVL SGTNQIHANV ERRSLMNLPY
AILDLRTNTE IDLVVPYVNY RNYVEITTSD TTGGAICVIV LGKYRHGNGT SNTVDFTLFG
ELLETDLQCP RPFDNQGKRK PRRRPIHKPK NPPQEPRVII QPGPGAANLS NSSVIAMAES
TALANEGTAV DYSTAGCASS VDDVIMVLRR WQILASFQWQ STLTPSTRIN RYQLIFRNIP
TFSLFFDKFQ YWRGSLEVKF MTFGSQFNTG RYQMSWYPIA DGEQSLAQCQ NSVFVTGDVC
ATPVTLTLPF TSTTWRKSTR DPYGYLMWHV VNRLTVNSSA PSNIDCTVLL RVGKDFQFTA
PLYGNLQMAT NNQGDSNQLG DDEPVCFLNF ETANVPIQGE SHTLVKHLFG RQWLVRTVQH
ASTVQELDLQ VPDRGHASLI RFFAYFSGEI ILTIVNNGTT PAMVAHSYSM DDLSSEYAVT
AMGGVMIPAN SAKNISVPFY SVTPLRPTRP IPGTSEATFG RLFMWTQSGS LSVFMGLKKP
ALFFPLPAPT STILSQKSKD VIPTLNQSGD EVDCHFCEIC SKMKRRWKPR GYFRFCLRLK
TLAFELNLEI ESDQIRNKKD LTTEGVEPNP GPILVVGKSG SGKSRLCNVL AGVELFESKL
SPRSVTMVHQ VETIDIEGKK VTIVDSPETP NYDGPISAFF YLIEAGRFTA EDKEYIQMMR
KRFPGFEKST ILILNRADEL KTDDDIRNWI KTSGELDSLV RACGGRIAKF HWHKINRAKL
LEKAATLPEF VSHLPRLVYK DRKIYRHYGV QCGSTVFHMD SENILESALN GEVTIKQEKW
NGNWKPAGDH MQSAASMYLK SQTMPKFTFS IDENCETWAR HLLGDYGETQ GQIFKERLMW
AAALGFFMTM KITTDQSFPG KDAIHTVLTK ISNFIFGGLE NEVVRVVIRT VIRIVCYLIL
YIHSPNIVTT GTLVALLALD ATSMSMDQGL KTLCMSLVDG DFGRFCSALL EKIQTVDEAD
LKKTIPRFND MLEDQSGKTT SPKSFNDWTT CAKNVQWWLE SFVKVVNWLK EKVFPSKTDP
TLQWLQDHEE HIAIMLALSD EHLCMLRTEK DYICEHNTRP KHQRLVEMVS GTLNQLQGIS
SARELAARLQ HVLNKLHQVH FEPELEWTHR PEPLGIWISG GPGIGKSFLS NYIVKEIAKL
KHWKSYANPT GSKHMDGYVS QEIHVFDDFG QNREEEDYSL ICNLISSIPF ITPKASVEAK
GTQYRGRLVV VTTNRRDFTS CKLTDPDALE RRFPIRLNIR PLQKYNHKGR LDVATAMRDG
SLQGGTCWER DIGQLGLECW NPINGQTLID EIMSELQVRQ EVASFMNQSK VRRFSDPETL
FSDLEDLKLE FDFDQLEQQA KLFAKPKEGK ISKFRAWVRD CIGKIKGFLE RNRAWILGIG
TLGTIMSLVT MCVPLARRFA QSIYSQQPVA KTLPKDFKVA VKKHIEKLET ELEDQSGRVN
FRHICNRLVN VSNEDEVATG LAIGGKNVLT FGHSKFTQLD EIRDMQFNAP AKGTPITYDG
EPTDLQLLEC DIPHQFKDVS KLIATEDYRG NGWLVWKDQD QYMVQDVTKI RPFGSTTTAS
GTTSCQTYIY NCKTGPGSCG GVLVAQIGGN LKILGIHTSG NGTMGAANRV FPVFNQGKVV
SKQYAGKILY HQPRKTAYMK SPVYEDSPYE PAVLSINDQR LGVKIEDMAK KASDKYIGNV
FQPPPEAFQL AKTHVAEKLS RVLGCHDIIS YESAVSSDVI PMNWDTSPGI KYKGETKRQL
VLKSSFRQDV MEQLQSPSTV FTCYLKDELR KKEKIKEGKT RGIEACNFDH TVAYRMVMGD
IFSNIYDDSF IISGCAVGIN PFCEWDNLLA NLQPYNLCLD FSGFDGSLSA QILEEAVDVL
SYFHNDPALV KRIHAPTIYS THYVTDEIWQ VEGGMCSGSP CTTVVNSIVN QLACYTILAV
LGYDINQCYV VSYGDDCVLS VPEVRDISKL SHYFKLFFGM TATASDKESD ITWLAPMEIE
FLKRTPAFLP GTRKIIGVLD KEVLEGKIQW CKGPEAFKQQ LDSFLLEAAL HGEEYYYEVT
SKLKARCPVL DIQPWGVAKL RAYTACMMI
//
