ID B1A4E7_PECCC Unreviewed; 689 AA.
AC B1A4E7;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Type 3 secretion system secretin {ECO:0000256|HAMAP-Rule:MF_02219};
DE Short=T3SS secretin {ECO:0000256|HAMAP-Rule:MF_02219};
GN Name=hrcC {ECO:0000313|EMBL:ABZ05763.1};
GN Synonyms=sctC {ECO:0000256|HAMAP-Rule:MF_02219};
OS Pectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp.
OS carotovora).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Pectobacteriaceae; Pectobacterium.
OX NCBI_TaxID=555 {ECO:0000313|EMBL:ABZ05763.1};
RN [1] {ECO:0000313|EMBL:ABZ05763.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=35 {ECO:0000313|EMBL:ABZ05763.1};
RA Nam H.S., Kang B.R., Choi H.S., Lee J.H., Cho S.M., Kim Y.-H., Cha J.S.,
RA Kim Y.C.;
RT "Identification by in vivo expression technology of HrpL-regulated genes in
RT Erwinia carotovora ssp. carotovora 35 causing soft-rot disease on Chinese
RT cabbage.";
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the type III secretion system (T3SS), also
CC called injectisome, which is used to inject bacterial effector proteins
CC into eukaryotic host cells. Forms a ring-shaped multimeric structure
CC with an apparent central pore in the outer membrane.
CC {ECO:0000256|HAMAP-Rule:MF_02219}.
CC -!- SUBUNIT: The core secretion machinery of the T3SS is composed of
CC approximately 20 different proteins, including cytoplasmic components,
CC a base, an export apparatus and a needle. This subunit is part of the
CC base, which anchors the injectisome in the bacterial cell envelope.
CC Forms a stable homooligomeric complex. {ECO:0000256|HAMAP-
CC Rule:MF_02219}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|ARBA:ARBA00004442, ECO:0000256|HAMAP-Rule:MF_02219,
CC ECO:0000256|RuleBase:RU004004}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the bacterial secretin family. T3SS SctC
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_02219}.
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DR EMBL; EU420066; ABZ05763.1; -; Genomic_DNA.
DR AlphaFoldDB; B1A4E7; -.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030257; C:type III protein secretion system complex; IEA:UniProtKB-UniRule.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.120; -; 2.
DR Gene3D; 3.55.50.30; -; 1.
DR HAMAP; MF_02219; Type_III_secretin; 1.
DR InterPro; IPR005644; NolW-like.
DR InterPro; IPR038591; NolW-like_sf.
DR InterPro; IPR010563; Pilus_assembly_TraK.
DR InterPro; IPR004846; T2SS/T3SS_dom.
DR InterPro; IPR003522; T3SS_OM_pore_YscC.
DR NCBIfam; TIGR02516; type_III_yscC; 1.
DR PANTHER; PTHR30332; PROBABLE GENERAL SECRETION PATHWAY PROTEIN D; 1.
DR PANTHER; PTHR30332:SF5; SPI-1 TYPE 3 SECRETION SYSTEM SECRETIN; 1.
DR Pfam; PF00263; Secretin; 1.
DR Pfam; PF03958; Secretin_N; 1.
DR Pfam; PF06586; TraK; 1.
DR PRINTS; PR01337; TYPE3OMGPROT.
PE 3: Inferred from homology;
KW Cell outer membrane {ECO:0000256|HAMAP-Rule:MF_02219};
KW Membrane {ECO:0000256|HAMAP-Rule:MF_02219, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|HAMAP-Rule:MF_02219};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|HAMAP-Rule:MF_02219};
KW Translocation {ECO:0000256|HAMAP-Rule:MF_02219};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|HAMAP-Rule:MF_02219, ECO:0000256|RuleBase:RU004004}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 195..319
FT /note="NolW-like"
FT /evidence="ECO:0000259|Pfam:PF03958"
FT DOMAIN 377..534
FT /note="Type II/III secretion system secretin-like"
FT /evidence="ECO:0000259|Pfam:PF00263"
SQ SEQUENCE 689 AA; 75631 MW; 5B12CBCACC0E2DB2 CRC64;
MRKGLIRHRS YSTLLAVYRW FCWAMVLMGI IPVNGIISLA HAATPPDWNK GAYAYSAEQT
PLSAILTDFA NSHGVDLVLG NIADNEVTAK IRADNPTLFL DRLALEHRFQ WFVYNNALYV
SPQDEQASVR LEISPDAAPD IKQALSGIGL LDARFGWGEL PEEGVVLVTG PQAYIDLIRN
FSQQREKQDE RRKVMIFPLR YASVSDRTLQ YRDQKVTIPG VATILNELMD GQRSAPAGAS
GPMPVQPDNG MEAMRDSTRS LMTRLATRNN PGRNGEASGR VTLSGKISAD VRNNALLIRD
DEKRRAEYQQ LVEHIDVPQN LVNIDAIILD VDRTAMSRLE ANWQAQLGNV SAGSTMMMGR
STLFVSDFKR FFADIQALEG EGTASIVANP SVLTLENQPA IVDFSRTAFI TATGERVADI
QPVTAGTSLQ VTPRVIGEGT QRSIQLVIDI EDGQVETGRE GEASGVKRGT VSTQALIGEN
RALVLGGFHV EESGDRDRRI PILGDIPLLG QLFTSTRHEV SRRERLFILT PHLVGDQTDP
TRYVSSANRQ QLNGAMNRVA QRNGKTDLYS LIEGAFRDLA SRQLPAGFQA DSKGARLGEV
CRSQSGLIYD SSRYQWYGNG QVRLSVGVVR NGGTQPQRFD EAACASSRTL AVAVWPKTTL
APGESSEVFL ALQPALTSQP ARRNLLTSQ
//
