ID B1AV35_MOUSE Unreviewed; 981 AA.
AC B1AV35;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Dystrophin related protein 2 {ECO:0000313|Ensembl:ENSMUSP00000108850.3};
GN Name=Drp2 {ECO:0000313|Ensembl:ENSMUSP00000108850.3,
GN ECO:0000313|MGI:MGI:107432};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000108850.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000108850.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000108850.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000108850.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000108850.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_006528559.1; XM_006528496.1.
DR AlphaFoldDB; B1AV35; -.
DR SMR; B1AV35; -.
DR MaxQB; B1AV35; -.
DR PeptideAtlas; B1AV35; -.
DR ProteomicsDB; 328228; -.
DR Antibodypedia; 506; 81 antibodies from 18 providers.
DR DNASU; 13497; -.
DR Ensembl; ENSMUST00000113224.9; ENSMUSP00000108850.3; ENSMUSG00000000223.14.
DR AGR; MGI:107432; -.
DR MGI; MGI:107432; Drp2.
DR VEuPathDB; HostDB:ENSMUSG00000000223; -.
DR GeneTree; ENSGT00940000153467; -.
DR OrthoDB; 2880153at2759; -.
DR PhylomeDB; B1AV35; -.
DR BioGRID-ORCS; 13497; 2 hits in 78 CRISPR screens.
DR ChiTaRS; Drp2; mouse.
DR Proteomes; UP000000589; Chromosome X.
DR Bgee; ENSMUSG00000000223; Expressed in sciatic nerve and 162 other cell types or tissues.
DR ExpressionAtlas; B1AV35; baseline and differential.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0050808; P:synapse organization; IEA:Ensembl.
DR CDD; cd16248; EFh_DRP-2; 1.
DR CDD; cd00176; SPEC; 1.
DR CDD; cd00201; WW; 1.
DR CDD; cd02334; ZZ_dystrophin; 1.
DR Gene3D; 1.20.58.60; -; 2.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268:SF16; DYSTROPHIN-RELATED PROTEIN 2; 1.
DR PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00435; Spectrin; 2.
DR Pfam; PF00397; WW; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00150; SPEC; 2.
DR SMART; SM00456; WW; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 2.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|MaxQB:B1AV35,
KW ECO:0007829|PeptideAtlas:B1AV35};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 376..409
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 629..685
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 900..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 806..900
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 903..922
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 981 AA; 110245 MW; B541FDDBE937BA18 CRC64;
MSGMLLTGFI TAAASETPVP SLRLAQSSSR FCLSALTRRE VQIPAEGKPW TALILPWTPQ
AAQVRAAVTI PAPPWDGAGD PCLSPKLLNG TVGATGPLEP SAMNLCWNEI KKKSHNLRAR
LEAFSDLSGK LQLPLREIID WLSQKDEELS AQLPLQGDVA LVQQEKETHA AFMEEVKSKG
PYISSVLESA QAFLSQHPFE ELEESQSESK DTSPRQRIQN LSRFVWKQAT VASELWEKLT
ARCVDQHRHI EHTLEHLLEI QGAMEELSST LTQAEGVRAT WEPIGDLFID SLPEHIQAIK
LFKEEFSPVK DGVKLVNDLA HQLAISDVHL SMENSRALEQ INIRWKQLQV SVAERLKQLQ
DAHRDFGPGS QHFLSTSVQV PWERAISPNK VPYYINHQAQ TTCWDHPKMT ELYQTLADLN
NIKFSAYRTA MKLRRVQKAL RLDLVTLTTA LEIFNEHDLQ ASEHVMDVVE VIHCLTALYE
RLEEERGILV NVPLCVDMSL NWLLNVFDSG RSGKMRALSF KTGIACLCGT EVKEKLQYLF
SQVANSGSQC DQRHLGALLH EAIQVPRQLG EVAAFGGSNV EPSVRSCFRF STGKPVIEAS
QFLEWVNLEP QSMVWLAVLH RVTIAEQVKH QTKCSICRQC PIKGFRYRSL KQFNVDICQT
CFLTGRASKG NKLHYPIMEY YTPTTSSENM RDFATTLKNK FRSKQYFSKH PQRGYLPVQS
VLESDCSETP ASSPMLPHAD THSRIEHFAS RLAEMESQNC SFFNDSLSPD DSIDEDQYLL
RHSSPITDRE PAFGQQAPCS MATESKGELE KILAHLEDEN RILQGELRRL KWQHEEAAEA
PTLVEGSAEA TPDHRNEELL AEARILRQHK SRLETRMQIL EDHNKQLESQ LQRLRELLLQ
PPSESDGNGS AGSSLASSPR QSEGSHPREK GQTTPDTEVA DDVGSKSQDV SLCLEDIMEK
LRHAFPSVRS SDVTANTLLA S
//
