ID B1AWH6_MOUSE Unreviewed; 471 AA.
AC B1AWH6;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Structural maintenance of chromosomes 2 {ECO:0000313|Ensembl:ENSMUSP00000114228.2};
DE Flags: Fragment;
GN Name=Smc2 {ECO:0000313|Ensembl:ENSMUSP00000114228.2,
GN ECO:0000313|MGI:MGI:106067};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000114228.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000114228.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000114228.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000114228.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000114228.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
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DR AlphaFoldDB; B1AWH6; -.
DR SMR; B1AWH6; -.
DR MaxQB; B1AWH6; -.
DR PeptideAtlas; B1AWH6; -.
DR ProteomicsDB; 318030; -.
DR Antibodypedia; 14701; 303 antibodies from 33 providers.
DR Ensembl; ENSMUST00000142227.3; ENSMUSP00000114228.2; ENSMUSG00000028312.20.
DR AGR; MGI:106067; -.
DR MGI; MGI:106067; Smc2.
DR VEuPathDB; HostDB:ENSMUSG00000028312; -.
DR GeneTree; ENSGT00550000074857; -.
DR HOGENOM; CLU_025409_0_0_1; -.
DR OMA; HNKIAME; -.
DR ChiTaRS; Smc2; mouse.
DR Proteomes; UP000000589; Chromosome 4.
DR Bgee; ENSMUSG00000028312; Expressed in pharyngeal arch 2 and 282 other cell types or tissues.
DR ExpressionAtlas; B1AWH6; baseline and differential.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03273; ABC_SMC2_euk; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR027120; Smc2_ABC.
DR PANTHER; PTHR43941; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2; 1.
DR PANTHER; PTHR43941:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2; 1.
DR Pfam; PF02463; SMC_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 1: Evidence at protein level;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|EPD:B1AWH6,
KW ECO:0007829|MaxQB:B1AWH6};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 2..277
FT /note="RecF/RecN/SMC N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02463"
FT COILED 246..294
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 324..351
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 402..471
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 471
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000114228.2"
SQ SEQUENCE 471 AA; 52803 MW; 4031450DCBAB405D CRC64;
MYVKSIILEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG ISNLSQVRAS
NLQDLVYKNG QAGITKASVS ITFDNSDKKQ SPLGFEAHDE ITVTRQVVIG GRNKYLINGV
NANNTRVQDL FCSVGLNVNN PHFLIMQGRI TKVLNMKPPE ILSMIEEAAG TRMYEYKKIA
AQKTIEKKEA KLKEIKTILE EEITPTIQKL KEERSSYLEY QKVMREIEHL SRLYIAYQFL
RAEDTKERSA GELKEMQDKI VNLQEVLSEN EKKIKALNCE IEELERRKDK ETGGKLKSLE
DACAEAQRVN TKSQSAFDLK KKNLASEETK RKELQNSMAE DSKALAAKEK EVKKITDGLH
GLQEASNKDA EALAAAQQHF NAVSAGLSSN EDGAEATLAG QMIACKNDIS KAQTEAKQAQ
MKLKHAQQEL KSKQAEVKKM DSGYKKDQDA FEAVKKAKEK LETEMKKLNY E
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