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Database: UniProt
Entry: B1AWN6_MOUSE
LinkDB: B1AWN6_MOUSE
Original site: B1AWN6_MOUSE 
ID   B1AWN6_MOUSE            Unreviewed;      2006 AA.
AC   B1AWN6;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   07-JUN-2017, entry version 89.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=Scn2a {ECO:0000313|Ensembl:ENSMUSP00000097645,
GN   ECO:0000313|MGI:MGI:98248};
GN   Synonyms=Scn2a1 {ECO:0000313|MGI:MGI:98248};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000097645, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000097645, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000097645,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000097645}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000097645};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000097645}.
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DR   EMBL; AL772235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX284648; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001092768.1; NM_001099298.3.
DR   UniGene; Mm.220329; -.
DR   UniGene; Mm.433692; -.
DR   STRING; 10090.ENSMUSP00000028377; -.
DR   Ensembl; ENSMUST00000028377; ENSMUSP00000028377; ENSMUSG00000075318.
DR   Ensembl; ENSMUST00000100067; ENSMUSP00000097645; ENSMUSG00000075318.
DR   GeneID; 110876; -.
DR   KEGG; mmu:110876; -.
DR   UCSC; uc008jwo.2; mouse.
DR   CTD; 6326; -.
DR   MGI; MGI:98248; Scn2a.
DR   eggNOG; ENOG410INF8; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   HOGENOM; HOG000231755; -.
DR   HOVERGEN; HBG053100; -.
DR   KO; K04834; -.
DR   OMA; ILPMNGK; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; ENSMUSG00000075318; -.
DR   GO; GO:0030424; C:axon; IDA:MGI.
DR   GO; GO:0014704; C:intercalated disc; IDA:MGI.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0016020; C:membrane; IDA:MGI.
DR   GO; GO:0033270; C:paranode region of axon; IDA:MGI.
DR   GO; GO:0030315; C:T-tubule; IDA:MGI.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; TAS:MGI.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IDA:MGI.
DR   GO; GO:0008627; P:intrinsic apoptotic signaling pathway in response to osmotic stress; IMP:MGI.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IMP:MGI.
DR   GO; GO:0051402; P:neuron apoptotic process; IMP:MGI.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0006814; P:sodium ion transport; IDA:MGI.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Proteomics identification {ECO:0000213|MaxQB:B1AWN6,
KW   ECO:0000213|PeptideAtlas:B1AWN6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    125    148       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    193    212       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    224    245       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    251    271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    401    428       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    752    776       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    788    809       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    871    899       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    961    984       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1210   1228       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1249   1271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1277   1297       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1326   1352       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1450   1474       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1533   1551       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1563   1581       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1593   1613       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1650   1678       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1754   1777       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      128    435       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      507    710       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      761    989       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      998   1204       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1208   1482       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1532   1787       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      425    470       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2006 AA;  227945 MW;  8A607C83C4E97F0D CRC64;
     MAQSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP KPNSDLEAGK
     SLPFIYGDIP PEMVSEPLED LDPYYINKKT FIVLNKGKAI SRFSATSALY ILTPFNPIRK
     LAIKILVHSL FNVLIMCTIL TNCVFMTMSN PPDWTKNVEY TFTGIYTFES LIKILARGFC
     LEDFTFLRDP WNWLDFTVIT FAYVTEFVNL GNVSALRTFR VLRALKTISV IPGLKTIVGA
     LIQSVKKLSD VMILTVFCLS VFALIGLQLF MGNLRNKCLQ WPPDNSTFEI NITSFFNNSL
     DWNGTAFNRT MNMFNWDEYI EDKSHFYFLE GQNDALLCGN SSDAGQCPEG YICVKAGRNP
     NYGYTSFDTF SWAFLSLFRL MTQDFWENLY QLTLRAAGKT YMIFFVLVIF LGSFYLINLI
     LAVVAMAYEE QNQATLEEAE QKEAEFQQML EQLKKQQEEA QAAAAAASAE SRDFSGAGGI
     GVFSESSSVA SKLSSKSEKE LKNRRKKKKQ KEQAGEEEKE DAVRKSASED SIRKKGFRFS
     LEGSRLTYEK RFSSPHQSLL SIRGSLFSPR RNSRASLFSF KGRVKDIGSE NDFADDEHST
     FEDNDSRRDS LFVPHRHGER RPSNVSQASR ASRGIPTLPM NGKMHSAVDC NGVVSLVGGP
     SALTSPVGQL LPEGTTTETE IRKRRSSSYH VSMDLLEDPT SRQRAMSMAS ILTNTMEELE
     ESRQKCPPCW YKFANMCLIW DCCKPWLKVK HVVNLVVMDP FVDLAITICI VLNTLFMAME
     HYPMTEQFSS VLSVGNLVFT GIFTAEMFLK IIAMDPYYYF QEGWNIFDGF IVSLSLMELG
     LANVEGLSVL RSFRLLRVFK LAKSWPTLNM LIKIIGNSVG ALGNLTLVLA IIVFIFAVVG
     MQLFGKSYKE CVCKISNDCE LPRWHMHDFF HSFLIVFRVL CGEWIETMWD CMEVAGQTMC
     LTVFMMVMVI GNLVVLNLFL ALLLSSFSSD NLAATDDDNE MNNLQIAVGR MQKGIDFVKR
     KIREFIQKAF VRKQKALDEI KPLEDLNNKK DSCISNHTTI EIGKDLNYLK DGNGTTSGIG
     SSVEKYVVDE SDYMSFINNP SLTVTVPIAV GESDFENLNT EEFSSESDME ESKEKLNATS
     SSEGSTVDIG APAEGEQPEA EPEESLEPEA CFTEDCVRKF KCCQISIEEG KGKLWWNLRK
     TCYKIVEHNW FETFIVFMIL LSSGALAFED IYIEQRKTIK TMLEYADKVF TYIFILEMLL
     KWVAYGFQMY FTNAWCWLDF LIVDVSLVSL TANALGYSEL GAIKSLRTLR ALRPLRALSR
     FEGMRVVVNA LLGAIPSIMN VLLVCLIFWL IFSIMGVNLF AGKFYHCINY TTGEMFDVSV
     VNNYSECQAL IESNQTARWK NVKVNFDNVG LGYLSLLQVA TFKGWMDIMY AAVDSRNVEL
     QPKYEDNLYM YLYFVIFIIF GSFFTLNLFI GVIIDNFNQQ KKKFGGQDIF MTEEQKKYYN
     AMKKLGSKKP QKPIPRPANK FQGMVFDFVT KQVFDISIMI LICLNMVTMM VETDDQSQEM
     TNILYWINLV FIVLFTGECV LKLISLRHYY FTIGWNIFDF VVVILSIVGM FLAELIEKYF
     VSPTLFRVIR LARIGRILRL IKGAKGIRTL LFALMMSLPA LFNIGLLLFL VMFIYAIFGM
     SNFAYVKREV GIDDMFNFET FGNSMICLFQ ITTSAGWDGL LAPILNSGPP DCDPEKDHPG
     SSVKGDCGNP SVGIFFFVSY IIISFLVVVN MYIAVILENF SVATEESAEP LSEDDFEMFY
     EVWEKFDPDA TQFIEFCKLS DFAAALDPPL LIAKPNKVQL IAMDLPMVSG DRIHCLDILF
     AFTKRVLGES GEMDALRIQM EERFMASNPS KVSYEPITTT LKRKQEEVSA IVIQRAYRRY
     LLKQKVKKVS SIYKKDKGKE DEGTPIKEDI ITDKLNENST PEKTDVTPST TSPPSYDSVT
     KPEKEKFEKD KSEKEDKGKD IRESKK
//
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