ID B1B3L4_STAAU Unreviewed; 585 AA.
AC B1B3L4;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Beta-lactam sensor/signal transducer BlaR1 {ECO:0000313|EMBL:MVK02807.1};
DE SubName: Full=Beta-lactamase regulatory protein {ECO:0000313|EMBL:GBV21716.1};
DE SubName: Full=Bla regulator protein blaR1 {ECO:0000313|EMBL:BAG12268.1};
GN Name=blaR1 {ECO:0000313|EMBL:BAG12268.1};
GN ORFNames=GO814_00535 {ECO:0000313|EMBL:MVK33634.1}, GO852_07585
GN {ECO:0000313|EMBL:MVK02807.1}, GO942_00740
GN {ECO:0000313|EMBL:MVM09218.1}, M1K003_2738
GN {ECO:0000313|EMBL:GBV21716.1};
OS Staphylococcus aureus.
OG Plasmid pTZ2162 {ECO:0000313|EMBL:BAG12268.1}.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1280 {ECO:0000313|EMBL:BAG12268.1};
RN [1] {ECO:0000313|EMBL:BAG12268.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TPS162 {ECO:0000313|EMBL:BAG12268.1};
RC PLASMID=pTZ2162 {ECO:0000313|EMBL:BAG12268.1};
RA Nakaminami H., Noguchi N., Nishijima S., Kurokawa I., Sasatsu M.;
RT "Characterization of the pTZ2162 encoding multidrug efflux gene qacB from
RT Staphylococcus aureus.";
RL Plasmid 60:108-117(2008).
RN [2] {ECO:0000313|Proteomes:UP000265645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M1K003 {ECO:0000313|Proteomes:UP000265645};
RA Nakamura Y., Takahashi H., Takaya A., Inoue Y., Katayama Y., Kusuya Y.,
RA Shoji T., Takada S., Nakagawa S., Oguma R., Ozawa N., Yamaide F.,
RA Suzuki S., Villaruz A., Otto M., Matsue H., Nunez G., Shimojo N.;
RT "Protection against atopic dermatitis through acquisition of Staphylococcus
RT quorum-sensing agr mutations in the skin.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:GBV21716.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M1K003 {ECO:0000313|EMBL:GBV21716.1};
RA Nakamura Y., Takahashi H., Takaya A., Inoue Y., Katayama Y., Kusuya Y.,
RA Shoji T., Takada S., Nakagawa S., Oguma R., Ozawa N., Yamaide F.,
RA Suzuki S., Villaruz A., Otto M., Matsue H., Nunez G., Shimojo N.;
RT "Protection against atopic dermatitis through acquisition of Staphylococcus
RT quorum-sensing agr mutations in the skin.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Proteomes:UP000430661, ECO:0000313|Proteomes:UP000471199}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S_1081.LBCF.DN {ECO:0000313|EMBL:MVM09218.1,
RC ECO:0000313|Proteomes:UP000478867}, S_2062.LAUP.DI
RC {ECO:0000313|EMBL:MVK33634.1, ECO:0000313|Proteomes:UP000471199}, and
RC S_2078.LLFX.AN {ECO:0000313|EMBL:MVK02807.1,
RC ECO:0000313|Proteomes:UP000430661};
RA Stine O.C.;
RT "Implementation of targeted gown and glove precautions to prevent
RT Staphylococcus aureus acquisition in community-based nursing homes.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M56 family.
CC {ECO:0000256|ARBA:ARBA00011075}.
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DR EMBL; AB304512; BAG12268.1; -; Genomic_DNA.
DR EMBL; BDVT01000021; GBV21716.1; -; Genomic_DNA.
DR EMBL; WPUV01000024; MVK02807.1; -; Genomic_DNA.
DR EMBL; WPTS01000005; MVK33634.1; -; Genomic_DNA.
DR EMBL; WPXC01000003; MVM09218.1; -; Genomic_DNA.
DR RefSeq; WP_001096381.1; NZ_WTUL01000011.1.
DR RefSeq; YP_001715978.1; NC_010419.1.
DR MEROPS; M56.001; -.
DR PATRIC; fig|1280.3588.peg.2345; -.
DR OMA; VNGWFIG; -.
DR Proteomes; UP000265645; Unassembled WGS sequence.
DR Proteomes; UP000430661; Unassembled WGS sequence.
DR Proteomes; UP000471199; Unassembled WGS sequence.
DR Proteomes; UP000478867; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR CDD; cd07341; M56_BlaR1_MecR1_like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR008756; Peptidase_M56.
DR PANTHER; PTHR30627:SF6; BETA-LACTAMASE YBXI-RELATED; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR Pfam; PF05569; Peptidase_M56; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius}; Plasmid {ECO:0000313|EMBL:BAG12268.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..298
FT /note="Peptidase M56"
FT /evidence="ECO:0000259|Pfam:PF05569"
FT DOMAIN 367..576
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 585 AA; 69052 MW; 4D31AE7C7F4E2C18 CRC64;
MAKLLIMSVV SFCFIFLLLV FFRYILKRYF NYSLNYKVWY LTMLAGLIPF IPIKFSFIKF
NNVNNQAPTV ESKSHDLNHN INTTKPIQEF TTDIHKFNWD SIDNICTVIW IVLVIILSFK
FLKALLYLKY LKKQSLYLNE NEKNKIDTIL FNHQYKKNIV IRKAEAIQSP ITFWYGKYII
LIPSSYFKSV IDKRLKYIIL HEYAHAKNRD TLHLIIFNIF SIIMSYNPLV HIVKRKIIHD
NEVEADRFVL NNINKNEFKT YAESIMDSVL KTPFSNKNIL SHSFNGKKSL LKSRLINIKE
ADLKKQSKLI LIFICIFTFF IMIIQSQFLM GQSLTDYNYK KPLQSDYQIL DESKNFGSNS
GSFVMYSMKK DKYYIYNEKE SRKRYSPDST YKIYLALFGL DRHIISDKNS RMSWNHKHYL
FESWNKEQDL NTAMQNSVNW YFERISNQIP KNYTAAQLKQ LNYGNENLGS YKSYWMEDSL
KISNLEQVIV FKNMMEQNNH FSKKAKNQLS SSLLIKKNEK YELYGKTGTG IVNGKYNNGW
FVGYVITNHD KYYFATHLSD GNPSGKNAEL ISEKILKGMG VLNDQ
//
