ID B1BRY5_CLOPF Unreviewed; 1023 AA.
AC B1BRY5;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Putative penicillin-binding protein {ECO:0000313|EMBL:EDT15600.1};
GN ORFNames=AC3_2727 {ECO:0000313|EMBL:EDT15600.1};
OS Clostridium perfringens E str. JGS1987.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=451755 {ECO:0000313|EMBL:EDT15600.1, ECO:0000313|Proteomes:UP000005337};
RN [1] {ECO:0000313|EMBL:EDT15600.1, ECO:0000313|Proteomes:UP000005337}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E str. JGS1987 {ECO:0000313|Proteomes:UP000005337};
RA Paulsen I., Sebastian Y.;
RT "Annotation of Clostridium perfringens E str. JGS1987.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDT15600.1}.
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DR EMBL; ABDW01000008; EDT15600.1; -; Genomic_DNA.
DR RefSeq; WP_003462729.1; NZ_ABDW01000008.1.
DR AlphaFoldDB; B1BRY5; -.
DR Proteomes; UP000005337; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 2.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 2.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 2.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..349
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 402..622
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 775..928
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 971..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 971..988
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 989..1003
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1023 AA; 114913 MW; ED8F437C50E6D555 CRC64;
MRSSINGKTP IDRYKILIGI MIIVFVSIVA RLVYLQVFNY EEFKQRADTR SMRFLSEQAP
RGKIYDSNGD ILATNRQTYT LTFTETDESK KNFYTTIDKV YSILKENNQS ILDNFKIRIN
ENGELYFDVS GDTEKLRLLK DIGMGDKVKN VLFKNKEGDL TAEEEDQIDN ELLKITPDEA
FNFLVKEYQL YDVLNPTEEE VKSYKNMEPK EITDILLKKY SLQDIRGYML VKNAMKMQSF
SGYKPVTIAK DINKETAFIF YQRLNDLPGI DVSIEPMRYY PYNELGSSFL GYVASINGDQ
KAKYEARGYD ASTDLIGKAG IEAAFENELK GVKGGTTVKV NSSGRKKEEL YDLESYPGNN
VHLTIDKDIQ YSAETSMKYL LDFLQTRNTL DSDANTKNAT RGAAVAIEVD TGKVLALVSY
PGFNPNEFAK GELDPVVAKE YFQPDYEAFA QQFIARNALN KTVDDLFPKN SKTGLREDLY
DLYPKRFYNY ATLGMIPPGS TFKPVTSVAA LEDKVITPSS TVYANGQNFG QTYPEIFGKN
PANWPRDKNY TGYADLYTAL EHSSNSYYFD SAVKMYYKNG GDPYGDGRYK KSSTEALDSI
AKYAWQFGLG VDPNSDKKAS TGIEISENFG QVYNFESFKN QTIALMRFTL VDSLEKGTFV
NSPSPDFPQV NIGVNDRDSK ELAAAKESIK KDIENSLNKL GDGNTIDEKA LSESLKKDFK
TLYNLDSAYQ ESIKNFSGIK GKDEDEKVDK AINLTVQRIV AWVVGDIAYQ IVSPRNLTDS
AIGQSISNFT PVQLASYVAT LANGGTRYKT HLVDKITDAQ GNLVEEFKPE VLNKVNMSKD
TLDAVKEGMR RVNAVGSAQY IMSRFPIVTA GKTGTATFRN DQSDYGRTDY GVYISFAPLD
NPKIAVATVL YDGGHGYYGS FIARTIYETY FREELKKDYP GYTPTNLDGA AYDYSLNPPL
EAIKDSNINS KVENAELDSS GKPVEGSQDN SSENKKEDDK SQNNNQDNNN QNDKTKVDEN
KAH
//
