ID B1C9J1_9FIRM Unreviewed; 968 AA.
AC B1C9J1;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Stage 0 sporulation protein A homolog {ECO:0000256|ARBA:ARBA00018672};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=ANASTE_02284 {ECO:0000313|EMBL:EDS72562.1};
OS Anaerofustis stercorihominis DSM 17244.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Anaerofustis.
OX NCBI_TaxID=445971 {ECO:0000313|EMBL:EDS72562.1, ECO:0000313|Proteomes:UP000005178};
RN [1] {ECO:0000313|EMBL:EDS72562.1, ECO:0000313|Proteomes:UP000005178}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17244 {ECO:0000313|EMBL:EDS72562.1,
RC ECO:0000313|Proteomes:UP000005178};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Anaerofustis stercorihominis (DSM 17244).";
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EDS72562.1, ECO:0000313|Proteomes:UP000005178}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17244 {ECO:0000313|EMBL:EDS72562.1,
RC ECO:0000313|Proteomes:UP000005178};
RA Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA Thiruvilangam P., Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play the central regulatory role in sporulation. It may
CC be an element of the effector pathway responsible for the activation of
CC sporulation genes in response to nutritional stress. Spo0A may act in
CC concert with spo0H (a sigma factor) to control the expression of some
CC genes that are critical to the sporulation process.
CC {ECO:0000256|ARBA:ARBA00024867}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDS72562.1}.
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DR EMBL; ABIL02000006; EDS72562.1; -; Genomic_DNA.
DR RefSeq; WP_007051032.1; NZ_DS560019.1.
DR AlphaFoldDB; B1C9J1; -.
DR STRING; 445971.ANASTE_02284; -.
DR eggNOG; COG0784; Bacteria.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_000445_114_21_9; -.
DR OrthoDB; 9804263at2; -.
DR Proteomes; UP000005178; Unassembled WGS sequence.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 2.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.10.450.50; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43047:SF72; OSMOSENSING HISTIDINE PROTEIN KINASE SLN1; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF13426; PAS_9; 1.
DR Pfam; PF00072; Response_reg; 2.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 2.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 2.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF54427; NTF2-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 2.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000005178};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 464..687
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 707..827
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 846..967
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 761
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
FT MOD_RES 898
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 968 AA; 111161 MW; EE57BC211BF7842F CRC64;
MGRLNKKEVI AFARKILRTY FVESRLDFLI STFDDDIIWL GGGRMQKAEG KEDVANWFIS
GKNDMFPCVM ENEDYQYMRL GDDYHMVEGV SDLYTSDNTE HIMFASQRIT FIFKEEDRKL
KTVHIHNSIP FDELKDEELF PVEYSKEQYD LLHEAYENKL SEIDSANEAI KNQAMLLNRL
YQSVPSGILQ LECEYPHNII IANHKIGQIY GIDEKDIKSG NYYNLLYKKI IESEDNISKV
LHNGGVIDYE REIIKYNKEK AWISVHLDVL NDVGGNDVIQ CVINDITKQK HALIEKENEQ
KLENSLLRSA IFSSNEAILN LNLTADTYSI ITSFEEVESD YRNIPRSGRY DDLIDKSCDL
MVHPDYKEEY RIKFDRQNVI KQFKSGKKEI YMELMELGED GEYHWKSYTF TRAENIYNED
IIGISIVKSL DKQRSERIRS EQLLKDALNA ARTANEAKSD FLSRMSHDIR TPLNAIIGMS
TIGKLKIEKP NSVLDCFSKI DSSSKYLLSL INDILDMSKI ESGKVTLNDE RFDFSEMIHE
INEIIYDQAV EKGIEYKVYS DINMDKYYIA DRLKLNQIFM NLLSNSLKYF SKGDFIHFSF
KEVKRERGVS LIEFIVEDSG CGMSKGFLDK LFLPFEQENA GVARNNVGTG LGLTIVKNIV
DIMEGNIEVI SEKGRGSKFI VTLPLGIIES EEEAEYRKKK ELLKGLNVLI ADDDEIVAKQ
IEVIMNDIGA EAVKVNSGSA AVDEVKKKYE NDEFFDVCFI DWKMPDMNGI ETTGNIRRIV
GEDTTIIIIT AYDWSVIEDE GRRAGVNHFI SKPVFEHTIC DYLTDIDVKH IRHRHKKSAK
SLKGRNVLLV KDNILNQEIA KSILEMRGMN VDTAENGKEA VDKFIKSDIG YYDMILMDIR
MPVMDGIEAT KAIRSSSHHR AQDIPIIAVS ANAFKEDKIK AFDAGINGYL IKPFDAGNMM
DMIEKFLN
//
