ID B1FKS2_9BURK Unreviewed; 395 AA.
AC B1FKS2;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Efflux transporter, RND family, MFP subunit {ECO:0000313|EMBL:EDT01861.1};
GN ORFNames=BamIOP4010DRAFT_4633 {ECO:0000313|EMBL:EDT01861.1};
OS Burkholderia ambifaria IOP40-10.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=396596 {ECO:0000313|EMBL:EDT01861.1, ECO:0000313|Proteomes:UP000005463};
RN [1] {ECO:0000313|EMBL:EDT01861.1, ECO:0000313|Proteomes:UP000005463}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IOP40-10 {ECO:0000313|EMBL:EDT01861.1,
RC ECO:0000313|Proteomes:UP000005463};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Larimer F., Land M.L., Hauser L.,
RA Tiedje J., Richardson P.;
RT "Sequencing of the draft genome and assembly of Burkholderia ambifaria
RT IOP40-10.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDT01861.1}.
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DR EMBL; ABLC01000152; EDT01861.1; -; Genomic_DNA.
DR RefSeq; WP_006753786.1; NZ_ABLC01000152.1.
DR AlphaFoldDB; B1FKS2; -.
DR PATRIC; fig|396596.7.peg.2836; -.
DR Proteomes; UP000005463; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF24; HLYD FAMILY SECRETION PROTEIN; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..395
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002763457"
FT DOMAIN 56..296
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT DOMAIN 297..363
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT REGION 376..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 395 AA; 41981 MW; AB877A0F2317189E CRC64;
MNNKRSLGRL LRLAPVALAA MLAVAGCGKG DKDKAPEAIQ NATVVTVRPT AMPMTVELPG
RLDAYRQAQV RARVAGIVTA RTYEEGQEVK QGAVLFRIDP APLKAARDAA QGALAKAQAA
ALAASDKRRR YDDLVRDHAV SERDHTEAVA DDTRAKADVA SAKAELARAQ LQLDYATVTA
PISGRARRAL VTEGALVGQD QATPLTTVEQ LDPIYVNFSQ PAADVDALRR AVKSGHATGI
AQHDVTVTLR RADGTAYPLK GKLLFSDLAV DPTTDTVAMR ALFPNPEREL LPGAYVRIAL
DAAVDQRAIL VPRDALLRTA ERTSVRVVGT NGKVKDVEVV ADQMSGRDWR VTRGLSGGER
VIVDNAAQFA PDTAVKPVEQ ASPTKAASAA AARQT
//
