ID   B1H1P4_XENLA            Unreviewed;       852 AA.
AC   B1H1P4;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=LOC431876 protein {ECO:0000313|EMBL:AAI60685.1};
DE   Flags: Fragment;
GN   Name=LOC431876 {ECO:0000313|EMBL:AAI60685.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:AAI60685.1};
RN   [1] {ECO:0000313|EMBL:AAI60685.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen {ECO:0000313|EMBL:AAI60685.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC160685; AAI60685.1; -; mRNA.
DR   AlphaFoldDB; B1H1P4; -.
DR   IntAct; B1H1P4; 1.
DR   MaxQB; B1H1P4; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0008649; F:rRNA methyltransferase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   HAMAP; MF_01547; RNA_methyltr_E; 1.
DR   HAMAP; MF_03163; RNA_methyltr_E_SPB1; 1.
DR   InterPro; IPR002877; RNA_MeTrfase_FtsJ_dom.
DR   InterPro; IPR015507; rRNA-MeTfrase_E.
DR   InterPro; IPR012920; rRNA_MeTfrase_SPB1-like_C.
DR   InterPro; IPR024576; rRNA_MeTfrase_Spb1_DUF3381.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR028589; SPB1-like.
DR   PANTHER; PTHR10920:SF13; PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3; 1.
DR   PANTHER; PTHR10920; RIBOSOMAL RNA METHYLTRANSFERASE; 1.
DR   Pfam; PF11861; DUF3381; 1.
DR   Pfam; PF01728; FtsJ; 1.
DR   Pfam; PF07780; Spb1_C; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   2: Evidence at transcript level;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          24..200
FT                   /note="Ribosomal RNA methyltransferase FtsJ"
FT                   /evidence="ECO:0000259|Pfam:PF01728"
FT   DOMAIN          233..393
FT                   /note="DUF3381"
FT                   /evidence="ECO:0000259|Pfam:PF11861"
FT   DOMAIN          631..851
FT                   /note="Ribosomal RNA methyltransferase SPB1-like C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07780"
FT   REGION          602..635
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          754..773
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        602..626
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        754..768
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         852
FT                   /evidence="ECO:0000313|EMBL:AAI60685.1"
SQ   SEQUENCE   852 AA;  96910 MW;  8AD8ABAEA9405378 CRC64;
     MGKKGKVGKS RKDKFYHLAK ETGYRSRSAF KLIQLNRKFQ FLQRARALVD LCAAPGGWLQ
     VAAKFMPVSS LIIGIDLVPI KPIPNVLTLQ EDITTEDCRQ AVKKHLQTWK ADVVLNDGAP
     NVGANWTHDA FSQVHLSLMA LRLACDCLSR GGWFITKIFR SSDYQSLLWI LQQFFKKVNS
     TKPQASRSES AEIFVVCQGF LAPDKIDTRF FDPKFAFKDV DGPVQTVSQL LSHKKPKAEG
     YAATSLSLYH CASLVDFLTV ENPVDFLSKT SEIALDDTEL EKHPATTNDI RECCRDIKVL
     GRKELRLLLN WRSKLRRHLA RKLKEASKES AMEIILSSDE EEEKQKKDIC DKDYNLEDEE
     LHRKLAEVKA EELTALKRKK KRILKTQRRQ RERVELKMDL PGVSIADEGE TGMFSLHTIG
     KNELLQTLSK GDMCAADSLI LDDIHNDDVV FSNDETEELE GVDEISLASD LEDYELQEIH
     ACEKSARNKR IQYPVKDCWM KDEVQINPLL VSLEDTSDRE QRDTSMWFGK GIFSSLDLGA
     DEDMEIKQMQ LLKGNKMGKI PLKMPDRIKN KPLQLGLATS AAKCVEKSGA ITSSTAKVTE
     FMQRSEETSS SKVCSKDISG KNDSSNSDSD NSEDEFIAKT MERSAGKRKE QGEEDKADFE
     VVAIERTVKR SRVVGPDGLA LGTVIATSKK STRDLIDGSF NRRNFNDDED ELPDWFVSEE
     RKHRIVQVPV DRHMMEDYRK RQRELNARPI KKVAEAKARK KRRTLKKMEQ MKKKAEAVVN
     TSDISEREKA AQLRSIYRKG VLGKEKPQVT YLVAKKGVGR KVRRPAGIKG HFKVVDGRMK
     KDMRSQRKKK KK
//