ID B1H384_XENTR Unreviewed; 704 AA.
AC B1H384;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
DE Flags: Fragment;
GN Name=LOC100145573 {ECO:0000313|EMBL:AAI61298.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI61298.1};
RN [1] {ECO:0000313|EMBL:AAI61298.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole embryo {ECO:0000313|EMBL:AAI61298.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMTC family.
CC {ECO:0000256|ARBA:ARBA00007882}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC161298; AAI61298.1; -; mRNA.
DR AlphaFoldDB; B1H384; -.
DR UniPathway; UPA00378; -.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR013618; TMTC_DUF1736.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44395; -; 1.
DR PANTHER; PTHR44395:SF1; PROTEIN O-MANNOSYL-TRANSFERASE TMTC3; 1.
DR Pfam; PF08409; TMTC_DUF1736; 1.
DR Pfam; PF00515; TPR_1; 2.
DR Pfam; PF13181; TPR_8; 5.
DR SMART; SM00028; TPR; 9.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 35..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 102..173
FT /note="DUF1736"
FT /evidence="ECO:0000259|Pfam:PF08409"
FT REPEAT 289..322
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 406..439
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 440..473
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 668..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 685..704
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAI61298.1"
FT NON_TER 704
FT /evidence="ECO:0000313|EMBL:AAI61298.1"
SQ SEQUENCE 704 AA; 80378 MW; B715B52B2B78DCC5 CRC64;
SYTKSKGPDN SIVWTPIAVA VFLVAVATLC KEQGITVVGI CCVYEVFIAQ GYTFPVLWDT
TLQILMGKGS IPYSMLQTLL KLIVLMFSTL LLVVVRVQVI QSQLPVFTRF DNPAAVSTTP
ARQLTFNYLL PVNAWLLLNP SELCCDWTMG TIPLIESILD IRNLATLLFY FLLGYLIVFS
VRYSGDSSKT VLMALCLIIL PFIPASNLFF PVGFVVAERV LYVPSMGFCM LVAHGWKKLS
SNGRLRTLSW IFLALVVFTH AIKTFNRNWD WESEYTLFTS ALKVNKNNAK LWNNVGHALE
NEKNYERALR FFKKATEVQP DDIGAHMNVG RTYKNLNRSK EAEESYLIAK ALMPQVIPGK
KYAARVAPNH LNVYINLANL IRANESRLEE ADQLYRQAIS MRPDFKQAYI SRGELLLKMN
KPLEAREAYI KALELDRMNA DLWYNLAIVY IELKDPSEAL RNFNQALELN PRHKLALFNS
ALLMQESGSA RLRPEAKRRL LTYVEEEPHD ANGYFNLGML AMDEKKDTEA EVWMKKAIQL
HHCFRSALFN LALLYSQTSR ELEALPVLDE LLRFYPDHSK GLILKGDILM NQKKDIKGAK
KCFEKIVEMD PNNVQGKHNL CVVYFEERDL IKAEKCLVET LALAPHEEYI QRHLSIVRGK
IMALNTAGQS VPPKEGALTL PEQKKIQKKK KKKKKKKKKK KKKK
//
