ID B1J2K6_PSEPW Unreviewed; 1102 AA.
AC B1J2K6;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=MscS Mechanosensitive ion channel {ECO:0000313|EMBL:ACA70905.1};
DE Flags: Precursor;
GN OrderedLocusNames=PputW619_0399 {ECO:0000313|EMBL:ACA70905.1};
OS Pseudomonas putida (strain W619).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=390235 {ECO:0000313|EMBL:ACA70905.1};
RN [1] {ECO:0000313|EMBL:ACA70905.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=W619 {ECO:0000313|EMBL:ACA70905.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S.,
RA Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Kim E., Taghavi S., Vangronsveld D., van der Lelie D.,
RA Richardson P.;
RT "Complete sequence of Psuedomonas putida W619.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000949; ACA70905.1; -; Genomic_DNA.
DR AlphaFoldDB; B1J2K6; -.
DR STRING; 390235.PputW619_0399; -.
DR KEGG; ppw:PputW619_0399; -.
DR eggNOG; COG3264; Bacteria.
DR HOGENOM; CLU_007829_3_0_6; -.
DR OrthoDB; 9799209at2; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR006686; MscS_channel_CS.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR025692; MscS_IM_dom1.
DR InterPro; IPR024393; MscS_porin.
DR PANTHER; PTHR30347:SF8; MECHANOSENSITIVE CHANNEL MSCK; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR Pfam; PF12795; MscS_porin; 1.
DR Pfam; PF12794; MscS_TM; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS01246; UPF0003; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1102
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002765406"
FT TRANSMEM 491..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 679..699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 711..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 779..803
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 829..850
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 871..892
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 898..925
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..270
FT /note="Mechanosensitive ion channel MscS porin"
FT /evidence="ECO:0000259|Pfam:PF12795"
FT DOMAIN 491..809
FT /note="Mechanosensitive ion channel inner membrane"
FT /evidence="ECO:0000259|Pfam:PF12794"
FT DOMAIN 870..911
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 913..978
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 986..1069
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT REGION 78..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 221..251
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1102 AA; 122458 MW; 1CAB6D5A40813758 CRC64;
MSLRVYLRTA LLGLCLSLSF AAAAAEAPSA ASIQNSLDKI AERKLPEADQ KALQQVLEQT
LSLLANKEDS EKKLAALKQQ LADAPKETSD SQKELAKLKA SKPQPVAQRY ASLSVPQLEQ
MLSERNTLQG ELQKALSDAN SLIINSQTRP ERAQAEISNN QTRSQQINTI LKSGKDGGKS
INADQRNQLN AELASLNAVT LLRRQELAGN GLLQDLGNAR HDLLIERTAR LEQEIQDLQT
LINEKRLAQS QQTVTQQSIE AQKAGGSSLL ASESAANLKL SDYLLKSTDR LNELTQQNLR
TKQQLDSLTQ ADQALDEQIS VLKGSLLLSK ILYKQKQALP HLKLDRDLAD QIADIRLYQF
EINQQREQMS SPVTYVDKLL ANQPQQDVTP ALRKALLEVA ITRSDLLERL NRELSALLNE
SITLQLNQKQ LLSTAQGLRT TLDEQMFWIP SNKPLDWDWL KTVPERFAKQ VADLPWGSGL
KELGDGLSQR PLLFLPLLLV IGALLWRRKY LYQRLNKVHQ DIGHFRRDSQ WHTPQAILIN
ILLAMPVSLG LALCSYALQI DARGQNANLG SALWQLAQAW LVFYTAYRIL APGGVAEIHF
RWHKPQVEFL RGWVRRLGTV VLALVGVVAV AEHQPSALAD DVLGIGVVLT CYALMAWLLS
RLLLSSPAHR DASLFRRAVG LAFTALPIAL FVAVCFGYYY TALKLTDRLI YTLYLLMFWL
VIEAAFVRGL SVAARRLAYQ RALSKRAAAK EGLDGEVITE EPTLDIEQVN QQSLRLIRLA
LLGGFIAGLY WVWADLITVF AYLNNFTLYE YTSGTGTAAS MVPISLGDLL GALVIVGITF
ALAGNLPGLL EVLVLSRLNL AQGSAYATTT LLSYTIVGIG IVSTLSTLGV SWDKLQWLVA
ALSVGLGFGM QEIFANFISG IMILFERPVR IGDTITIGNL SGTVSKIRIR ATTITDFDRK
DIIVPNKTFI TGQLINWSLT DTVTRVTLKL GIDYGSDLDL VRELLLKGAH ENPRVLKDPE
PLVYFLNFGE SSLDHELRMH VRDLGDRNPT LDEINRFINR EFKAHNIKIS VRQVEVYLMD
MQGGKQQLIP VEQPKPDGTQ PV
//
