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Database: UniProt
Entry: B1JYJ6
LinkDB: B1JYJ6
Original site: B1JYJ6 
ID   UBIE_BURCC              Reviewed;         243 AA.
AC   B1JYJ6;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   19-MAR-2014, entry version 51.
DE   RecName: Full=Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE;
DE            EC=2.1.1.163;
DE            EC=2.1.1.201;
DE   AltName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase;
DE   AltName: Full=Demethylmenaquinone methyltransferase;
GN   Name=ubiE; OrderedLocusNames=Bcenmc03_2759;
OS   Burkholderia cenocepacia (strain MC0-3).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=406425;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC0-3;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Burkholderia cenocepacia MC0-
RT   3.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Methyltransferase required for the conversion of
CC       demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the
CC       conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to
CC       2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: A demethylmenaquinone + S-adenosyl-L-
CC       methionine = a menaquinol + S-adenosyl-L-homocysteine.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + 2-methoxy-6-all-
CC       trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-
CC       methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.
CC   -!- PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis;
CC       menaquinone-2 from chorismate: step 8/8.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. UbiE family.
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DR   EMBL; CP000958; ACA91919.1; -; Genomic_DNA.
DR   RefSeq; YP_001766041.1; NC_010508.1.
DR   ProteinModelPortal; B1JYJ6; -.
DR   STRING; 406425.Bcenmc03_2759; -.
DR   EnsemblBacteria; ACA91919; ACA91919; Bcenmc03_2759.
DR   GeneID; 6124422; -.
DR   KEGG; bcm:Bcenmc03_2759; -.
DR   PATRIC; 19092756; VBIBurCen61509_2860.
DR   eggNOG; COG2226; -.
DR   HOGENOM; HOG000249463; -.
DR   KO; K03183; -.
DR   OMA; IWKRFTI; -.
DR   OrthoDB; EOG6M6JSB; -.
DR   ProtClustDB; PRK00216; -.
DR   BioCyc; BCEN406425:GHD9-2832-MONOMER; -.
DR   UniPathway; UPA00079; UER00169.
DR   UniPathway; UPA00232; -.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01813; UbiE_methyltran; 1.
DR   InterPro; IPR004033; UbiE/COQ5_MeTrFase.
DR   InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR   Pfam; PF01209; Ubie_methyltran; 1.
DR   TIGRFAMs; TIGR01934; MenG_MenH_UbiE; 1.
DR   PROSITE; PS51608; SAM_MT_UBIE; 1.
DR   PROSITE; PS01183; UBIE_1; 1.
DR   PROSITE; PS01184; UBIE_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Menaquinone biosynthesis; Methyltransferase;
KW   S-adenosyl-L-methionine; Transferase; Ubiquinone biosynthesis.
FT   CHAIN         1    243       Ubiquinone/menaquinone biosynthesis C-
FT                                methyltransferase UbiE.
FT                                /FTId=PRO_1000187737.
SQ   SEQUENCE   243 AA;  27093 MW;  12C04D3F86D3C4F9 CRC64;
     MSKTHFGFES VEENEKAKKV AGVFHSVASN YDLMNDLMSA GMHRAWKAFT IAQANVRPGF
     KVLDIAAGTG DLTKSFAKAA GPTGEVWHTD INESMLRVGR DRLLDKGVVT PSLLCDAEKI
     PFPDNYFDVV TVAFGLRNMT HKDAALAEMR RVTKPGGRVM VLEFSKVWDP LKKAYDLYSF
     KVLPWLGDKF AKDAESYRYL AESIRMHPDQ DTLKTMMEQA GLDAVKYYNL SGGVVALHLG
     TKY
//
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