ID UBIE_BURCC Reviewed; 243 AA.
AC B1JYJ6;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 01-MAY-2013, entry version 43.
DE RecName: Full=Ubiquinone/menaquinone biosynthesis methyltransferase ubiE;
DE EC=2.1.1.163;
DE EC=2.1.1.201;
DE AltName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase;
DE AltName: Full=Demethylmenaquinone methyltransferase;
GN Name=ubiE; OrderedLocusNames=Bcenmc03_2759;
OS Burkholderia cenocepacia (strain MC0-3).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=406425;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC0-3;
RA Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L.,
RA Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P.,
RA Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Tiedje J., Richardson P.;
RT "Complete sequence of chromosome 1 of Burkholderia cenocepacia MC0-
RT 3.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Methyltransferase required for the conversion of
CC demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the
CC conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to
CC 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: A demethylmenaquinone + S-adenosyl-L-
CC methionine = a menaquinol + S-adenosyl-L-homocysteine.
CC -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + 2-methoxy-6-all-
CC trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-
CC methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.
CC -!- PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis;
CC menaquinone-2 from chorismate: step 8/8.
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. UbiE
CC family.
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DR EMBL; CP000958; ACA91919.1; -; Genomic_DNA.
DR RefSeq; YP_001766041.1; NC_010508.1.
DR ProteinModelPortal; B1JYJ6; -.
DR STRING; 406425.Bcenmc03_2759; -.
DR EnsemblBacteria; ACA91919; ACA91919; Bcenmc03_2759.
DR GeneID; 6124422; -.
DR KEGG; bcm:Bcenmc03_2759; -.
DR PATRIC; 19092756; VBIBurCen61509_2860.
DR eggNOG; COG2226; -.
DR HOGENOM; HOG000249463; -.
DR KO; K03183; -.
DR OMA; PYQYLVE; -.
DR ProtClustDB; PRK00216; -.
DR BioCyc; BCEN406425:GHD9-6654-MONOMER; -.
DR UniPathway; UPA00079; UER00169.
DR UniPathway; UPA00232; -.
DR GO; GO:0008425; F:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; IEA:HAMAP.
DR GO; GO:0009060; P:aerobic respiration; IEA:HAMAP.
DR GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_01813; UbiE_methyltran; 1; -.
DR InterPro; IPR004033; UbiE/COQ5_MeTrFase.
DR InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR InterPro; IPR025765; UbiE/COQ5_MeTrFase_dom.
DR PANTHER; PTHR10108:SF24; PTHR10108:SF24; 1.
DR Pfam; PF01209; Ubie_methyltran; 1.
DR TIGRFAMs; TIGR01934; MenG_MenH_UbiE; 1.
DR PROSITE; PS01183; UBIE_1; 1.
DR PROSITE; PS01184; UBIE_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Menaquinone biosynthesis; Methyltransferase;
KW Transferase; Ubiquinone biosynthesis.
FT CHAIN 1 243 Ubiquinone/menaquinone biosynthesis
FT methyltransferase ubiE.
FT /FTId=PRO_1000187737.
SQ SEQUENCE 243 AA; 27093 MW; 12C04D3F86D3C4F9 CRC64;
MSKTHFGFES VEENEKAKKV AGVFHSVASN YDLMNDLMSA GMHRAWKAFT IAQANVRPGF
KVLDIAAGTG DLTKSFAKAA GPTGEVWHTD INESMLRVGR DRLLDKGVVT PSLLCDAEKI
PFPDNYFDVV TVAFGLRNMT HKDAALAEMR RVTKPGGRVM VLEFSKVWDP LKKAYDLYSF
KVLPWLGDKF AKDAESYRYL AESIRMHPDQ DTLKTMMEQA GLDAVKYYNL SGGVVALHLG
TKY
//
