ID   B1KS08_CLOBM            Unreviewed;      1350 AA.
AC   B1KS08;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   RecName: Full=DNA helicase {ECO:0008006|Google:ProtNLM};
GN   OrderedLocusNames=CLK_3276 {ECO:0000313|EMBL:ACA55297.1};
OS   Clostridium botulinum (strain Loch Maree / Type A3).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=498214 {ECO:0000313|EMBL:ACA55297.1, ECO:0000313|Proteomes:UP000000722};
RN   [1] {ECO:0000313|EMBL:ACA55297.1, ECO:0000313|Proteomes:UP000000722}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Loch Maree / Type A3 {ECO:0000313|Proteomes:UP000000722};
RX   PubMed=18060065; DOI=10.1371/journal.pone.0001271;
RA   Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C.,
RA   Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.;
RT   "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4
RT   and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within
RT   plasmids.";
RL   PLoS ONE 2:E1271-E1271(2007).
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DR   EMBL; CP000962; ACA55297.1; -; Genomic_DNA.
DR   RefSeq; WP_012343299.1; NC_010520.1.
DR   KEGG; cbl:CLK_3276; -.
DR   HOGENOM; CLU_000738_1_0_9; -.
DR   Proteomes; UP000000722; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR049468; Restrct_endonuc-II-like_dom.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR43788:SF8; HELICASE WITH ZINC FINGER 2; 1.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF18741; MTES_1575; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          266..393
FT                   /note="DNA2/NAM7 helicase helicase"
FT                   /evidence="ECO:0000259|Pfam:PF13086"
FT   DOMAIN          1011..1194
FT                   /note="DNA2/NAM7 helicase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13087"
FT   DOMAIN          1237..1329
FT                   /note="Restriction endonuclease type II-like"
FT                   /evidence="ECO:0000259|Pfam:PF18741"
SQ   SEQUENCE   1350 AA;  159631 MW;  32ADDAC3D720ED76 CRC64;
     MKCSEKIKNI FYYLLRIKRM NKCSSDVRTY EALYTKKDIL NNSYCNVSRD KEDNVTIKIS
     KEAGKIYDKI YKQYLDGGNE NEIILGQAIL ALRKNKNIIH PVITSKVKVD FIDKENVLSL
     KIPSNIKLEI EVCDCLNKTL FKKIISRKNY WEKEKIDIMN YDNIKDKIQL LLNNDSEIVF
     KDIEDLNKIE ITEEPVIYNC PILVIRKTDN SLWSKEFESI AEEIDNGYDI PKTIEALVEE
     KEIEDDYIHK DQWKECKEDI LFPLDANEEQ ISIVKKICEN EAILVQGPPG TGKSHTIANL
     ICHFLAHGKK VLITSETSRA LRVLINKIPK DIKPLCVNLL DDNNGEYELE QCIKNISDNL
     CKNPSEIIDD IYILNNERKE CKKNQQVLYN KLKEIEFMEN KKIHCKGNYY KLIHIGSWLN
     ENEYKYGWIR DNIRYEDIKP VNEEQFNKLI ELLKNNGKEY IGNINELIFI CNKIPSYNEV
     ENKLDRMIYL ESNLNFYKDK IKGWYIPAEC KCNYDILSDF LYDCIEKMKN ITKDPMLGKM
     FELYYSSEIF RDSINNFTLN LNSSKEKLIK IRANINRYSI EIKEIKDMDM FIKDYERVYS
     KIKGKKKISK IFKVINSKYD YIFKNCYING ENIKSIEQLN IINDYIEERK IYNFLNRLWE
     NIINSYIQED SNYNIDNLIS IERITNNLDT IMNWNREYRD KIIKLLGRIR IPININWYEI
     NTYEYFIQCI ECIKAINEYN DLKAFMEIIK KQVRNFESLN PIIKGIDKEN IDYIKEAYSY
     IEKIMSMKSD MDEINYIYKK LEESCPRTLE FILENYKKNY KFNSWENAWK WAQYNNLFKK
     LEKIDEKTLQ GQLIEEKNKE KEIINQIISK KAWKNIILNI NEGEKRSLFS WVQAVKRIGK
     GRGKFVLQYS NIAKEEMEKC KSIIPVWIMP LEKVIENIKP SKEQFDVVIF DESSQSNIFA
     ISALMRAKKA IIVGDDKQIS PEIVGMDQGM ISNFIDKYLD GIPHNQWFDL QTSLYDTALR
     TFKDRIMLKE HFRSVPEIVQ FSNKLCYGDL IVPLRYPKIK EAFNSPIKCI KVEDGYREKT
     KQININEAKA LVNKLLECCR DSKYNGMTMG VISLLGDAQS EFIENLLKNN LSKEEIKIRK
     LVCGDAYSFQ GDERDIIFLS MVVGDNMKYT ALTKETDIKR FNVAASRARN QIFLFYSIDY
     KNINNDCVRY KLIDYCNNYK NYKSKLPDIN YVMQSKFQKD IYNNIRNLKC DIKSNIKLGK
     YIIDFILEGE HNRIAIICDD GNLYENNNVE KVLNLEMDLT RLGWAFYKIR GSKFYRNPEV
     EVEKLHKFLI ESGLYKDDSK EILKNNLLVV
//