ID B1L3C1_KORCO Unreviewed; 334 AA.
AC B1L3C1;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=3-isopropylmalate dehydrogenase {ECO:0000313|EMBL:ACB06950.1};
DE EC=1.1.1.85 {ECO:0000313|EMBL:ACB06950.1};
GN OrderedLocusNames=Kcr_0190 {ECO:0000313|EMBL:ACB06950.1};
OS Korarchaeum cryptofilum (strain OPF8).
OC Archaea; Candidatus Korarchaeota; Korarchaeum.
OX NCBI_TaxID=374847 {ECO:0000313|EMBL:ACB06950.1, ECO:0000313|Proteomes:UP000001686};
RN [1] {ECO:0000313|EMBL:ACB06950.1, ECO:0000313|Proteomes:UP000001686}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OPF8 {ECO:0000313|Proteomes:UP000001686};
RX PubMed=18535141; DOI=10.1073/pnas.0801980105;
RA Elkins J.G., Podar M., Graham D.E., Makarova K.S., Wolf Y., Randau L.,
RA Hedlund B.P., Brochier-Armanet C., Kunin V., Anderson I., Lapidus A.,
RA Goltsman E., Barry K., Koonin E.V., Hugenholtz P., Kyrpides N., Wanner G.,
RA Richardson P., Keller M., Stetter K.O.;
RT "A korarchaeal genome reveals new insights into the evolution of the
RT Archaea.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:8102-8107(2008).
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000968; ACB06950.1; -; Genomic_DNA.
DR RefSeq; WP_012308847.1; NC_010482.1.
DR AlphaFoldDB; B1L3C1; -.
DR STRING; 374847.Kcr_0190; -.
DR EnsemblBacteria; ACB06950; ACB06950; Kcr_0190.
DR GeneID; 6093479; -.
DR KEGG; kcr:Kcr_0190; -.
DR eggNOG; arCOG01163; Archaea.
DR HOGENOM; CLU_031953_0_1_2; -.
DR InParanoid; B1L3C1; -.
DR OrthoDB; 23624at2157; -.
DR PhylomeDB; B1L3C1; -.
DR Proteomes; UP000001686; Chromosome.
DR GO; GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IBA:GO_Central.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0006102; P:isocitrate metabolic process; IBA:GO_Central.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF34; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:ACB06950.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001686}.
FT DOMAIN 3..321
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 334 AA; 36756 MW; 52AFC0D74A01D937 CRC64;
MPRIAVIPGD GVGPEIIDAV IPVLETLSDL MNLPLDLRFF EAGDETKRKR GVALPEETLN
GVMNSDATLM VAIGESAREV ILPLRQKLDL YVNLRPAKSY PVPRAIPGFD LTIVRENTED
LYVMSGWRGL DTAVDLRIIT RRASERICRF GYRYARERGK SRVYVVHKAN VLGGCMLFRE
VCSRVAEEEG FDYREMYVDS AAMRIAMDRP FDVIITTNMF GDILSDLAAA FIGGLGMYPS
ANIGESRAIF EPVHGTAPEI AGKNIANPMA TILSAAMMMG WLGHEGGSKL IEEAVRRACE
LGYTTPDVGG SMRTKEVGLK ISEIMREIGG SINF
//
