ID B1L671_KORCO Unreviewed; 249 AA.
AC B1L671;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=tRNA(His) guanylyltransferase {ECO:0000256|ARBA:ARBA00012511};
DE EC=2.7.7.79 {ECO:0000256|ARBA:ARBA00012511};
GN OrderedLocusNames=Kcr_1204 {ECO:0000313|EMBL:ACB07950.1};
OS Korarchaeum cryptofilum (strain OPF8).
OC Archaea; Candidatus Korarchaeota; Korarchaeum.
OX NCBI_TaxID=374847 {ECO:0000313|EMBL:ACB07950.1, ECO:0000313|Proteomes:UP000001686};
RN [1] {ECO:0000313|EMBL:ACB07950.1, ECO:0000313|Proteomes:UP000001686}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OPF8 {ECO:0000313|Proteomes:UP000001686};
RX PubMed=18535141; DOI=10.1073/pnas.0801980105;
RA Elkins J.G., Podar M., Graham D.E., Makarova K.S., Wolf Y., Randau L.,
RA Hedlund B.P., Brochier-Armanet C., Kunin V., Anderson I., Lapidus A.,
RA Goltsman E., Barry K., Koonin E.V., Hugenholtz P., Kyrpides N., Wanner G.,
RA Richardson P., Keller M., Stetter K.O.;
RT "A korarchaeal genome reveals new insights into the evolution of the
RT Archaea.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:8102-8107(2008).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the tRNA(His) guanylyltransferase family.
CC {ECO:0000256|ARBA:ARBA00010113}.
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DR EMBL; CP000968; ACB07950.1; -; Genomic_DNA.
DR RefSeq; WP_012309847.1; NC_010482.1.
DR AlphaFoldDB; B1L671; -.
DR STRING; 374847.Kcr_1204; -.
DR EnsemblBacteria; ACB07950; ACB07950; Kcr_1204.
DR GeneID; 6094481; -.
DR KEGG; kcr:Kcr_1204; -.
DR eggNOG; arCOG03218; Archaea.
DR HOGENOM; CLU_044271_3_1_2; -.
DR InParanoid; B1L671; -.
DR OrthoDB; 24661at2157; -.
DR PhylomeDB; B1L671; -.
DR Proteomes; UP000001686; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0008193; F:tRNA guanylyltransferase activity; IBA:GO_Central.
DR GO; GO:0006400; P:tRNA modification; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IBA:GO_Central.
DR Gene3D; 3.30.70.3000; -; 1.
DR InterPro; IPR025845; Thg1_C_dom.
DR InterPro; IPR024956; tRNAHis_GuaTrfase_cat.
DR InterPro; IPR007537; tRNAHis_GuaTrfase_Thg1.
DR InterPro; IPR038469; tRNAHis_GuaTrfase_Thg1_sf.
DR PANTHER; PTHR12729:SF6; TRNA(HIS) GUANYLYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR12729; UNCHARACTERIZED; 1.
DR Pfam; PF04446; Thg1; 1.
DR Pfam; PF14413; Thg1C; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000001686};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 18..126
FT /note="tRNAHis guanylyltransferase catalytic"
FT /evidence="ECO:0000259|Pfam:PF04446"
FT DOMAIN 133..213
FT /note="Thg1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14413"
SQ SEQUENCE 249 AA; 28788 MW; 32BDDB89EDB9BC55 CRC64;
MNASIRSVDW KEREIFSGLR VPSDAPVMVR IDGWRFHKVA DELGLERPFD RRLIEALIQA
PLSLMRMGFP LALSFAFSDE ISFLIYPPIP WSGRVEKLIS VIPSHSSAIV SMFLNYPVCF
DARIIILRDL DEILGYLSWR QSEAWRNALN SYALFALERS GMNREDAVKE LRNRKADSLH
DIIFTKLGIN IATVPSWQRR GVIVRKRYEE KHCESGKVVR RVPEVDWDIP LFSTPEGRDY
LLEALRALE
//
