ID B1L7G1_KORCO Unreviewed; 530 AA.
AC B1L7G1;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN OrderedLocusNames=Kcr_0028 {ECO:0000313|EMBL:ACB06788.1};
OS Korarchaeum cryptofilum (strain OPF8).
OC Archaea; Candidatus Korarchaeota; Korarchaeum.
OX NCBI_TaxID=374847 {ECO:0000313|EMBL:ACB06788.1, ECO:0000313|Proteomes:UP000001686};
RN [1] {ECO:0000313|EMBL:ACB06788.1, ECO:0000313|Proteomes:UP000001686}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OPF8 {ECO:0000313|Proteomes:UP000001686};
RX PubMed=18535141; DOI=10.1073/pnas.0801980105;
RA Elkins J.G., Podar M., Graham D.E., Makarova K.S., Wolf Y., Randau L.,
RA Hedlund B.P., Brochier-Armanet C., Kunin V., Anderson I., Lapidus A.,
RA Goltsman E., Barry K., Koonin E.V., Hugenholtz P., Kyrpides N., Wanner G.,
RA Richardson P., Keller M., Stetter K.O.;
RT "A korarchaeal genome reveals new insights into the evolution of the
RT Archaea.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:8102-8107(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the HerA family.
CC {ECO:0000256|ARBA:ARBA00007816}.
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DR EMBL; CP000968; ACB06788.1; -; Genomic_DNA.
DR RefSeq; WP_012308685.1; NC_010482.1.
DR AlphaFoldDB; B1L7G1; -.
DR STRING; 374847.Kcr_0028; -.
DR EnsemblBacteria; ACB06788; ACB06788; Kcr_0028.
DR GeneID; 6094965; -.
DR KEGG; kcr:Kcr_0028; -.
DR eggNOG; arCOG00280; Archaea.
DR HOGENOM; CLU_023842_2_0_2; -.
DR InParanoid; B1L7G1; -.
DR OrthoDB; 107033at2157; -.
DR PhylomeDB; B1L7G1; -.
DR Proteomes; UP000001686; Chromosome.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR018538; HerA_barrel_dom.
DR InterPro; IPR002789; HerA_central.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR42957; HELICASE MJ1565-RELATED; 1.
DR PANTHER; PTHR42957:SF1; HELICASE MJ1565-RELATED; 1.
DR Pfam; PF01935; DUF87; 1.
DR Pfam; PF09378; HAS-barrel; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:ACB06788.1};
KW Helicase {ECO:0000313|EMBL:ACB06788.1};
KW Hydrolase {ECO:0000313|EMBL:ACB06788.1};
KW Nucleotide-binding {ECO:0000313|EMBL:ACB06788.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001686}.
FT DOMAIN 8..92
FT /note="Helicase HerA barrel"
FT /evidence="ECO:0000259|Pfam:PF09378"
FT DOMAIN 131..360
FT /note="Helicase HerA central"
FT /evidence="ECO:0000259|Pfam:PF01935"
SQ SEQUENCE 530 AA; 58881 MW; A0366C4688632D1F CRC64;
MGSDSLGKVA PGTTPLSVQM VAYEGVIPRV GEYVILEDGD VRVLGMITDV IMGASELERE
DLLQANYYDK ILKLIERPSN WIKASIKMIG VLDGSNISGT PKIPVSPAAD VKRAPTNILT
EIFKPNDGDG IRIGSLMTRD DVDVYLDPDE ILSRHLAILA VTGAGKSNTV AVILEEILRL
GGVALLFDVH SEYSNMSLDC DGCYVETIQP EIDPLTLSID EVAKLIGISY ESAAKMYIFL
KRAHKNAKNL LMREELGDYI RRAGIDGDPQ DLLAGIHAIV KLSADEEGGS DDENLLRYEY
RDRESILSLL ARLEHVRERY SRVLVSRAGE IVDHLNYGKL VVVDLGQLDT ELTDIVVGKT
LLTLLDRAKK RRMGSDVWMP IPVLSVIEEA HILVPSMMDT YTNYAASKIA REGRKFGIGL
CLVSQRPKGI NTDILSQMVN KIILRVIEPE DQAYIRRATE FLSEDMVKYL PSLDIGEAVV
VGPMLKIPAL IKVRLSKAKR RGESLKAREL WKRGIERKDF RDDYYSAIGD
//
