ID B1LNX4_ECOSM Unreviewed; 1105 AA.
AC B1LNX4;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Sensory box-containing diguanylate cyclase {ECO:0000313|EMBL:ACB18272.1};
GN OrderedLocusNames=EcSMS35_0993 {ECO:0000313|EMBL:ACB18272.1};
OS Escherichia coli (strain SMS-3-5 / SECEC).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=439855 {ECO:0000313|EMBL:ACB18272.1, ECO:0000313|Proteomes:UP000007011};
RN [1] {ECO:0000313|EMBL:ACB18272.1, ECO:0000313|Proteomes:UP000007011}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SMS-3-5 / SECEC {ECO:0000313|Proteomes:UP000007011};
RX PubMed=18708504; DOI=10.1128/JB.00661-08;
RA Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C.,
RA Ravel J., Stepanauskas R.;
RT "Insights into the environmental resistance gene pool from the genome
RT sequence of the multidrug-resistant environmental isolate Escherichia coli
RT SMS-3-5.";
RL J. Bacteriol. 190:6779-6794(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP000970; ACB18272.1; -; Genomic_DNA.
DR RefSeq; WP_000043747.1; NC_010498.1.
DR AlphaFoldDB; B1LNX4; -.
DR KEGG; ecm:EcSMS35_0993; -.
DR HOGENOM; CLU_000445_126_1_6; -.
DR Proteomes; UP000007011; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 3.
DR Gene3D; 2.10.70.100; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR007895; MASE1.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF05231; MASE1; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF13426; PAS_9; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00086; PAC; 3.
DR SMART; SM00091; PAS; 3.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 3.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50113; PAC; 3.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 39..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 300..370
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 374..426
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 501..552
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 553..605
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 626..680
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 712..845
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 855..1104
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 1105 AA; 123974 MW; B38EA8DB306DA6ED CRC64;
MSKQSQHVLI ALPHPLLHLV SLGLVSFIFT LFSLELSQFG TQLAPLWFPT SIMMVAFYRH
AGRMWPGIAL SCSLGNIAAS ILLFSTSSLN MTWTTINIVE AVVGAVLLRK LLPWYNPLQN
LADWLRLALG SAIVPPLLGG VLVILLTPGD DPLRAFLIWV LSESIGALAL VPLGLLFKPH
YLLRHRNPRL LFESLLTLAI TLTLSWLSML YLPWPFTFII VLLMWSAVRL PRMEAFLIFL
TTVMMVSLMM AADPSLLATP RTYLMSHMPW LPFLLILLPA NIMTMVMYAF RAERKHISES
ETRFRNAMEY SAIGMALVGT EGQWLQSNKA LCQFLGYSQE ELRGLTFQQL TWPEDLNKDL
QQVEKLISGE INTYSMEKRY YNRNGDVVWA LLAVSLVRHT DGTPLYFIAQ IEDINELKRT
EQVNQQLMER ITLANEAGGI GIWEWELKPN IFSWDKRMFE LYEIPPHIKP NWQVWYECVL
PEDRQHAEKV IRDSLQSRSP FKLEFRITVK DGIRHIRALA NRVLNKEGEV ERLLGINMDM
TEVKQLNEAL FQEKERLHIT LDSIGEAVVC IDMAMKITFM NPVAEKMSGW TQEEALGVPL
LTVLHITFGD NGPLMENIYS ADTSRSAIEQ DVVLHCRSGG SYDVHYSITP LSTLDGSNIG
SVLVIQDVTE SRKMLRQLSY SASHDALTHL ANRASFEKQL RILLQTVNST HQRHALVFID
LDRFKAVNDS AGHAAGDALL RELASLMLSM LRSSDVLARL GGDEFGLLLP DCNVESARFI
ATRIISAVND YHFIWEGRVH RVGASAGITL IDDNNHQAAE VMSQADIACY ASKNGGRGRV
TVYEPQQAAT NSERAVMSLD EQWRMIKENQ LMMIAHGVAS PRIPQARNLW LISLKLWSCE
GEIIDEQTFR RSFSDPALSH ALDRRVFHDF FQQTAKAIAS KGLSIALPLS VAGLSSATLV
NELIEQLENS PLPPRLLHLI IPADAILDHA ESVQKLRLAG CRIVFSQVGR DLQIFNSLKA
NMADYLLLDG ELCANVQGNL MDEMLITIIQ GHAQRLGMKT IAGPVVLPLV MDTLSGIGVD
LIYGDVIADA QPLDLLVNSS YFAIN
//
