UniProt: B1LZR4

Database: UniProt
Entry: B1LZR4_METRJ

LinkDB:  B1LZR4_METRJ 
Original site:  B1LZR4_METRJ

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Ontology (5)   
   GO (5)   
Gene (1)   
   KEGG GENES (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (45)   
   InterPro (25)   
   Pfam (9)   
   PROSITE (5)   
   SMART (6)   
All databases (52)   

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ID   B1LZR4_METRJ            Unreviewed;      2485 AA.
AC   B1LZR4;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:ACB22962.1};
GN   OrderedLocusNames=Mrad2831_0952 {ECO:0000313|EMBL:ACB22962.1};
OS   Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 /
OS   NBRC 15690 / NCIMB 10815 / 0-1).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=426355 {ECO:0000313|EMBL:ACB22962.1, ECO:0000313|Proteomes:UP000006589};
RN   [1] {ECO:0000313|EMBL:ACB22962.1, ECO:0000313|Proteomes:UP000006589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 /
RC   0-1 {ECO:0000313|Proteomes:UP000006589};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium radiotolerans JCM
RT   2831.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP001001; ACB22962.1; -; Genomic_DNA.
DR   STRING; 426355.Mrad2831_0952; -.
DR   KEGG; mrd:Mrad2831_0952; -.
DR   PATRIC; fig|426355.14.peg.991; -.
DR   eggNOG; COG0604; Bacteria.
DR   eggNOG; COG3321; Bacteria.
DR   HOGENOM; CLU_000022_31_5_5; -.
DR   OrthoDB; 9778690at2; -.
DR   Proteomes; UP000006589; Chromosome.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   CDD; cd05195; enoyl_red; 1.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.30.70.3290; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR049551; PKS_DH_C.
DR   InterPro; IPR049552; PKS_DH_N.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE   4: Predicted;
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          9..431
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          2361..2438
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   2485 AA;  263024 MW;  F62A57FF43CA7688 CRC64;
     MCEPNVTQRT DIAIVGRACR LPGAPSVDGL WSLLSEGRCA VSKVPADRFS LERFAHPRAH
     ERGKSYTWAA GVIDDVWSFD PAVFGISPRE AEQMDPQQRM LLELTWEALE DAGLRPSSVA
     GSNIGVFVGA SSLDYGNLRI LDAPSGDAYA ATGNTLSIIS NRISYIFDLK GPSFTVDTAC
     SSSLVAFDNA VQAIRSGRVD TAVVAGVNVL ASPFNFICFS TAQMLSRTGL CQAFSKNADG
     YVRSEGGVVF VLQSAEAARR NGATVRAVVA ASGINSDGRT TGISLPSGYA QGALLEKVYR
     EAEIRLDDLA FMEAHGTGTP VGDPIEASAI GSKLGRGRQA PLPIGSIKTN IGHTEPVSGL
     AGLMKATLAL EHDLVPPSLH AAELNPEIPF GELNLHVVRE AMPISRGARE RFAGVNSFGF
     GGTNAHVVIT DAPAWAKPAA ATAEPQAQVL LLSAQSRAAL NELALDYAER LESAPEQVAT
     VAAAVAHRRE RMPARLAVAL DGKADVAAAL RAVGEGEDTP DAFTGTAVDR VAEVAFIYSG
     NGSQWAGMGR EAYEENAVFR ATFDRIDTLF RAYSDWSLKD ALYADDLDER LALTSVSQPL
     IFAIESASTA ALKAKGLIPS YVLGHSVGEI AAAEAAGILS LEDAVRVIYY RSHHQETTHG
     QGTMAVLLMP SEEVETFLKD YPTLDIAAYN SPKAVTVAGP VADIDAALKA LSRKRRRGRK
     LDLAYAFHGR LMDPTEKPLL RDLAGLKAKA GTTAMVSTVT GSVLDGSHFG AGYWWRNIRE
     PVRFCEAVQD ATRRGARVFV EVGPRATLMS HVGDAVEPLG IETATVGVMH RKASGGDPIA
     KAVSAALVQG AQVDETLLFG DAPKGDVRLP TYPWQRRPFR LADTTEGVGA MSPRPYHPLI
     GSRTAFDGLE WNGFVDPVTV PELEDHKVDG QVIMPGAGFV EMALACVREA LRDDAVVLAD
     FEIVAPMVFA EDALREVAVR LSGSGNGIQV LSRPRLTQTP WQLHAQAKIV EGSFSAPKAP
     DLDGFSFETA GDHVLTGDAL YAKALASGLG FGPSFQQVAM SARLDDATIV SDLLPAEPDT
     RYGLVPNRLD ACFHGLILLF ADLLGENGGK AYIPVRFGEV RLLRPGAVIA RSIIRTRRCN
     ERSILADFTL LDAEGAVIAT IREGRFQALR AKSGGDLSAF AISQVPELAT EPTAIPMERR
     PSVAARLRPL AAEAKGPADA ALSPGHLLLE GWATSLAYRL ASGLAQGETV TVTDSRVPEA
     LRPWLLNALY ALESSGLAER AGPNWTLGDG SALPAPDEIM RWIAGDHPDL SAELVLIADV
     GALVDRLLAG TLSDAPALPQ GAIDAFVLRS ATARHGADVV ADLIERSRAQ LPKERALRVL
     QVGFGPLSAQ TATFAAAAEA RLTVFETDRR LAERARLSLG RAAAVVETAE ELAPGSFDLI
     LASGSLHRGD RALPGQLAGA LATGGLLVAV EPGASLFRDL VFGLTAGWFE EAAGGLPVGR
     LEDIEGWQRI LSAHGLVKVE VERAASANGD DLLLTAEAPV RPGPAPAQSF AFIIGSDDEF
     AAETASSLAT LLVAGGVHVS IILDSETSLM ELEKETPDTV VFLAGAFTRG GEAAERLRDR
     CLSLKRCTEH LGSRQTRLWV VAPGATRDRG GQTTNIEAGV WAFSRTLANE APNLDVRRID
     LSPEMSSKRA SERLRDLILS GTPETEIVLD DERTQVVRFH AGRPQHRDPA DAVPAEAARL
     ERSNTGGLSE MVWGPAERRA PGKGEMEIAV EATGLNFRDV LWALSMLPEE ILEDGFAGPR
     LGLECAGRVT AVGPGVKGFK VGDPVVAFAQ SGFATHIVVP DLVVAPMPQG LDPMAAATVP
     VAFLTAYYGL VSCARMRRGE WVLVHGGAGG VGLAALQIAK LKGARVIATA GSREKRALVK
     ALGAEHVLDS RSLAFVDEVR AITGDGVDIV LNSLFGEAME RSLNALRPFG RFVELGKRDY
     VANTHIGLRP FRRNLSYFGV DLDQVIQHQG DDGARMFREV MALFNDGGLK PLPYQPFTAA
     ETSDAFRLMQ QSGHIGKIVI SPPKAGTIMK DTARPFTVSA EGVHLLTGGL GGFGLEAARW
     LIDRGAKHLV LAGRKGAATD EAKAIVAELT ARGVTVEAKA VDITSRASVD RLIAGIEQGG
     KKLAGVLHAA AVLQDGLISN IDAAALDAVI GPKVIGAQHL DAATRDRSLD YFVLFSSATT
     FIGNPGQGSY VAANGFMEGL ARQRRRRGLP ALAVAWGAIG DVGMLARNKA VMEGLAGRVG
     VTPMEARRCL DLMAEALGSQ GASPDEGVIA IAAMHWGKAR ERLATMRSPS YAELGSDQQA
     EAGGVQAINI AALLKGGDLD AVRKTVSDAI VEDIARILRL PKDDISRVRQ LSEIGLDSLM
     GVELGASLQE RFALDAPPAG LSSGMTVNEL SESLIQAVSA PMDETAGVAM SLVSKHVGGE
     VDAQILAPLK ELIEQTSSEI KETNS
//

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