ID B1M4V3_METRJ Unreviewed; 777 AA.
AC B1M4V3;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) {ECO:0000313|EMBL:ACB24999.1};
GN OrderedLocusNames=Mrad2831_3015 {ECO:0000313|EMBL:ACB24999.1};
OS Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 /
OS NBRC 15690 / NCIMB 10815 / 0-1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylobacteriaceae; Methylobacterium.
OX NCBI_TaxID=426355 {ECO:0000313|EMBL:ACB24999.1, ECO:0000313|Proteomes:UP000006589};
RN [1] {ECO:0000313|EMBL:ACB24999.1, ECO:0000313|Proteomes:UP000006589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 /
RC 0-1 {ECO:0000313|Proteomes:UP000006589};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Marx C.J., Richardson P.;
RT "Complete sequence of chromosome of Methylobacterium radiotolerans JCM
RT 2831.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP001001; ACB24999.1; -; Genomic_DNA.
DR RefSeq; WP_012319966.1; NC_010505.1.
DR AlphaFoldDB; B1M4V3; -.
DR STRING; 426355.Mrad2831_3015; -.
DR KEGG; mrd:Mrad2831_3015; -.
DR PATRIC; fig|426355.14.peg.3083; -.
DR eggNOG; COG5001; Bacteria.
DR HOGENOM; CLU_000445_70_49_5; -.
DR OrthoDB; 9814202at2; -.
DR Proteomes; UP000006589; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR PANTHER; PTHR44757:SF12; MEMBRANE PROTEIN-RELATED; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF08448; PAS_4; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50113; PAC; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 294..345
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 376..509
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 518..768
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 777 AA; 86027 MW; E8CAE0B3916F2D44 CRC64;
MLISFLIDTD RKADPLDANL RARARVEQLD VALRLVPFTI LVSLSVVQVI VYLFWNPANR
AYLAGLETLI LPLAVVSLQQ CWRWRSRPKP LQVPSSFVQG VVLAAQAYGF LLASIPVMLF
SGADAHGRLL IASSIAGLIA TGMSAAVLPR VAIGYSGLII LGSFIALATT GEAFYIYVAV
LLFFYAIFIC FTILHLSRLL TMRVIAQIEL ERQQEFTHLL LNEFEESASD WLWETDADLR
LQHVSPRLIE VAGSSERQLM GLPLERLLLP PVAPPRSHSS TTLWSCIAER RAFRNLHLQL
DIAGERRTWC LSGKPTFDRA GAFSGYRGVG SDVTEKRRSE ERLSYLALHD SLTDLPNRVL
FHQLQEAARE RLAQGDRFAV LALDLDEFKS VNDTFGHAAG DKLLKSVAER LRSFEASDVQ
LARLAGDEFA VLATGRSARD LHAIEALANG IVEALASPFT IDGIRLTVSV SIGIAIAPQD
GCQEIMRRAD LALYRMKSEG RNGYRFYEAE MDERIEARRA LTADLRGALD RDEFVLYFQP
IVAAKECRVR GFEALIRWKH PVRGFVSPGE FIPLAEETGV IIPLGEWILR EACRIAAGWP
GDVRIAVNLS PRQFRHSDLT QLVRSALRTS GLAAARLELE VTESVFLEAT PAINATLSKL
REMGVRLSLD DFGTGYSSLS YLRRIAFDKI KIDQSFVRDL PQERGAAAIV SAIIDMATSL
DMTITAEGVE TDAQRACLLE QGCHEFQGYL FSKPLPAEQA AALARSRQLL PAAVRAA
//
