ID B1M714_METRJ Unreviewed; 357 AA.
AC B1M714;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Naringenin-chalcone synthase {ECO:0000313|EMBL:ACB26673.1};
DE EC=2.3.1.74 {ECO:0000313|EMBL:ACB26673.1};
GN OrderedLocusNames=Mrad2831_4712 {ECO:0000313|EMBL:ACB26673.1};
OS Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 /
OS NBRC 15690 / NCIMB 10815 / 0-1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylobacteriaceae; Methylobacterium.
OX NCBI_TaxID=426355 {ECO:0000313|EMBL:ACB26673.1, ECO:0000313|Proteomes:UP000006589};
RN [1] {ECO:0000313|EMBL:ACB26673.1, ECO:0000313|Proteomes:UP000006589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 /
RC 0-1 {ECO:0000313|Proteomes:UP000006589};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Marx C.J., Richardson P.;
RT "Complete sequence of chromosome of Methylobacterium radiotolerans JCM
RT 2831.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531}.
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DR EMBL; CP001001; ACB26673.1; -; Genomic_DNA.
DR RefSeq; WP_012321626.1; NC_010505.1.
DR AlphaFoldDB; B1M714; -.
DR STRING; 426355.Mrad2831_4712; -.
DR KEGG; mrd:Mrad2831_4712; -.
DR PATRIC; fig|426355.14.peg.4785; -.
DR eggNOG; COG3424; Bacteria.
DR HOGENOM; CLU_034992_0_2_5; -.
DR OrthoDB; 9786288at2; -.
DR Proteomes; UP000006589; Chromosome.
DR GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR PANTHER; PTHR11877:SF46; TYPE III POLYKETIDE SYNTHASE A; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:ACB26673.1};
KW Transferase {ECO:0000313|EMBL:ACB26673.1}.
FT DOMAIN 7..214
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 226..354
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 152
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 357 AA; 38895 MW; 41CA092747F55D1E CRC64;
MTEAYLNRIE TAVPPHDVHA AFAAFARSQL ADDQRKLRIL DRMVERSGIA HRYSCLAPGL
DPGRDAVDAE GLYRPRRFPT TADRMRLYEK HAPALATRAV DKLELGDQRD RITHLVVSSC
TGFSAPGLDI DIIERCGLRG SVERTMVGFM GCYAAINALK IARHIVRSEP RARVLVLNIE
LCTLHLQETS DLEQILTFLL FADGCAASIV SADPTGLRLD AFNALLTPNT RQLLTWHIRE
SGFDMVLSGR VPAAVQEGIS GRADEFLAGN RIPDVDAWAV HPGGRTVLDA VERAFALPPS
ALAVSRNILR RFGNMSSATV MFVLAALMDQ ATAGQVGCAM AFGPGLVAET MMFRKAA
//
