ID B1MAM0_MYCA9 Unreviewed; 1002 AA.
AC B1MAM0;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Membrane protein, MmpL family {ECO:0000313|EMBL:CAM62291.1};
GN OrderedLocusNames=MAB_2210c {ECO:0000313|EMBL:CAM62291.1};
OS Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CCUG 20993 / CIP
OS 104536 / JCM 13569 / NCTC 13031 / TMC 1543 / L948) (Mycobacterium
OS abscessus).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacteroides; Mycobacteroides abscessus.
OX NCBI_TaxID=561007 {ECO:0000313|EMBL:CAM62291.1, ECO:0000313|Proteomes:UP000007137};
RN [1] {ECO:0000313|EMBL:CAM62291.1, ECO:0000313|Proteomes:UP000007137}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 /
RC TMC 1543 {ECO:0000313|Proteomes:UP000007137};
RX PubMed=19543527; DOI=10.1371/journal.pone.0005660;
RA Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M.,
RA Macheras E., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L.,
RA Gaillard J.L.;
RT "Non mycobacterial virulence genes in the genome of the emerging pathogen
RT Mycobacterium abscessus.";
RL PLoS ONE 4:E5660-E5660(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CU458896; CAM62291.1; -; Genomic_DNA.
DR RefSeq; WP_005092322.1; NZ_MLCG01000002.1.
DR AlphaFoldDB; B1MAM0; -.
DR GeneID; 66972581; -.
DR KEGG; mab:MAB_2210c; -.
DR Proteomes; UP000007137; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 64..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 821..840
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 847..870
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 876..898
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 919..944
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 964..984
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 101..429
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 692..987
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 1002 AA; 106880 MW; C867C22E39C54030 CRC64;
MKKKDESEAD TGPIAAPVGA ETFSARSRAF GRRVRNEFVV PFRRGTYAGT STNAGQRRPL
YARLLYGLSI PIVILWVLLA CGLNAAGPQL EKVIEGHALS FLPDEASSVQ ALANMGKYFG
NGGTNNFVAV LAEGDKPFGA EMHRYYADLM EKFKADNKHV ITTIDLWSDP SFAPAFESRD
RKASFSYLNL AGNMGTALAM ESTQAVRDIV KAYPPPDGVK IYVTGPSAVV NDELLAINRS
ILPIIIACAI CITIIMSLTY RSLFTASMPL LVVAVALVTA RPIVALLGQH GIIGISIFAS
SLLAGIVLGA GTDYGIFLLG RYQEARRAGQ DPTSAYYTAL SSVQRIIFAS GLTVAGATAC
MTLTRLAAFS TSGLPCTIGI LTALAAALTL GPALLAIGCR LGLYEPRGDR AVRRWRRIAT
HVVRWPGPVL AGSLAVLALA ILVLPTYVIS YNERAAQPAN TEANLGLDAA DRHLPPNLLN
PNLLFVESDH DMRNSADLIA LAKLTNAVYS VDGVQAVQGI TRPLISPLPQ GTLTYQGGYI
GERMSQIAEM VSTQLNGIAR ITGQIDQLSV GVKVVLKDLE VTQRAVELPG GAGNATRQRL
IELLKTAKGI HNEMQPLLAS GIDAAGQLVD MVPDCRQLIP CNSALTGLAV LDGLNQSGGR
KFEDLVDASR IASESLPNLV SQVRLLDRFL ADSQRTLTPI RGMADSLLVQ MNEVTAFLRE
IADTYMKGDP SGYFFLPSQA FESPLFQSAL SVFFSPDGKI TRMLVMGDVN SFSKESMDYS
AKIIPTAKAA LKGTSLGGSK ISIGGAGGTL LNIAAFAKED FITSAVAAFA FVFCVVLLLL
RSFVAAVAVV GTVGLSFLSA WGLSVAIWQY GIGLPLHWAV APCSFIFLVA VGADYNLLLV
ARFKEELRAG IKTGIIRSMV GTGSVVTTAG LIFGFTMFAL IAGYSSTLAQ IGTTVGVGLL
LDTLIVRSLV IPSIATLLGR WFWWPMRVPC RAFRETDPAV IR
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