ID B1MAR8_MYCA9 Unreviewed; 1985 AA.
AC B1MAR8;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 95.
DE SubName: Full=Peptide synthetase and polyketide synthase {ECO:0000313|EMBL:CAM62339.1};
GN OrderedLocusNames=MAB_2258 {ECO:0000313|EMBL:CAM62339.1};
OS Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CCUG 20993 / CIP
OS 104536 / JCM 13569 / NCTC 13031 / TMC 1543 / L948) (Mycobacterium
OS abscessus).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacteroides; Mycobacteroides abscessus.
OX NCBI_TaxID=561007 {ECO:0000313|EMBL:CAM62339.1, ECO:0000313|Proteomes:UP000007137};
RN [1] {ECO:0000313|EMBL:CAM62339.1, ECO:0000313|Proteomes:UP000007137}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 /
RC TMC 1543 {ECO:0000313|Proteomes:UP000007137};
RX PubMed=19543527; DOI=10.1371/journal.pone.0005660;
RA Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M.,
RA Macheras E., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L.,
RA Gaillard J.L.;
RT "Non mycobacterial virulence genes in the genome of the emerging pathogen
RT Mycobacterium abscessus.";
RL PLoS ONE 4:E5660-E5660(2009).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU458896; CAM62339.1; -; Genomic_DNA.
DR RefSeq; WP_005110759.1; NZ_MLCG01000006.1.
DR GeneID; 66972629; -.
DR KEGG; mab:MAB_2258; -.
DR OMA; APMANRE; -.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000007137; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd08953; KR_2_SDR_x; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 1874..1949
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 796..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1950..1985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1985 AA; 212252 MW; 6BBFC55655FD63C6 CRC64;
MTAVDYRPAP ESGEEIILFR ASFAQQRMWF LSRLEPGSHY YNVPIVLHFR GAVRRDALQR
ALAGMVSRHE ILRTTFVEVE GEVMQAVAAD SAVPVPLTAI ESSAAHSLPP IARPEVRTAV
LELVCTPFDL SSGPLLRAHL LDVQDGEYLL VLTMHHIIVD GWSIGVICKE LRELYASEVG
GIPAALPSLE LQIGDLAEQE HELMSAPTRE RHLAYWRSQL AGDLSAPALP FDRDRPSRNV
FHGATVDFTL SPSDTAVIAA FGRDRDATIF ATLLAAFYAL LYRYSGSDDQ VVGAPMANRE
DHRVSALIGL FVNTVPLRAR VDPNAGFAAL VSHVREVTLG AYEHQELPLE QIIDEVAPTR
LPGRNPMVAV LFAMQSPPPV DLDFAGTRAS FVGVPTGTTR ADVEMHFWPL GDRIGVQFVY
STELFDAATV EQMRDDYTAL LRAALASPHL PIGHLPLGAG EALVVQSLAP MFRHAENSVA
IVDAGVEITH AHLRKTAAQL VAAMPGVRGG TVVLGFERGS DLVAAVVAAV SAGAGRLVWL
PASLPAPYRE HSLRQLAPTA VVDDATVADA AATGIRAMGE SETLNTDAAV GLLDSSLAEL
LVALLYSGRI DLKNDAPASR AVLTADGRSA PPGVLGELCI GRPGEGVLPT GIQARMRRDS
SVEIAHTVRG CVWDGNRWAD LTTVEAVLID HELVDDCAVL SRRINSGTAE LVAYVATSAP
ASTRRLAEIA RTVLPPLLVP RAFVPVAALP VTPAGALDSA ALARLPVIDD ELVEQWSARL
PEATMVRAVP DIDEAPSVLV GDPNPPAKQA PAAPGAQPGG QEPSVLHGGP AVIPVVASLP
GALTRAAREA ATTELVFLDE SGTERTLNYA EVLDSAQRVL GGLRAVGMAP GDLAIVHLSR
NDDFVAAIWG CFLGGIVPVP VAPNVVGGTE KVAAAWHTLK QPLIVGEIPQ PVAHQGARVL
LIGDLLTHEP DTDHHEPDPD EVALLLLTSG STGQPKGVQL SHRNILSRSA STAQSNAFGP
EDISFNWMPL EHVGGIVMSH LQDVYVHCRQ VHAATSWVLA DPLRWLTIAD RYGVTNTWAP
NFAFGLIADR LAETPDAAQF DLTRLRFILN GGEAIVPRVA RRFLRMMEGF GLPRNAMRPS
WGMSETSSGV VFSQNFSIET TADTDEFTDL GGPIPGTRLR VADMDGSVVP EGQIGRVQIS
GPTVTRGYYA DPERTAEAFA TDGWFDTGDL GRIRAGVLTL TGRAKDIIIV NGVNYSCHAI
ESAVEESPLV ISSYVAAIAV RLPGSDTDGL AIVFSAQAAV AEEDVLADVR ARVLAVGPNP
DLLIPVPPES IPKTDIGKIQ RNLLRQQFAE GKFADIVRRV RTSGAPTDTI PNWFFRPLWH
RRDRLRPSVP VDGAVLLLGD SGALGSLLAD RLRAQGAHVV CAAVADVAER SDRPAGVGAV
QTVVYLAAPQ EDDAKAKNHP ELLAGSLLDV ARIVRSVTNG RFNEPPPAVY VVGRGIERVA
NTDMADPELA PIPVLLRSAV AEMPGLRVRF IDLDPRDLAA GADDIVGELG YATNDIEVAY
RDGVRWVKGL QRLPDDATLA AQIPSGAVHL ISGGLGGLAY ELARMLIERF DGRVLLVGHR
DPDERQLAAY RRLCDIAGGA SVRLEVADVC DTGRVWDAVT AAENAWGIQL AGIWHLAGIY
REQSLAAMTD AEFADIARAK VGGARALHAI ALHRPGIRFV SFSSVNGFFG GSTVGGYSVA
NAYLDAFALY QRRTCGIAAH SVAWTMWDRV GMSAQVEHVE GTRARGYRVV GRVAALNSLL
VALAHDEPHV LVGLDDTKPA IRARLSGVAP AGQVLVADLA EAVPGFADMP LRDKYDAIVP
TRVQSAGVAR TFVAARDETE RRVSGIWRRV LGSDHFGVTD SFFDIGGNSV LLALAQRLVQ
EEFGCQIALV DLFRYPTVSS LAVYLSSREF ASDPSDPEPV AVADAGVGSG RARIRQEARR
RRRAR
//