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Database: UniProt
Entry: B1MC92
LinkDB: B1MC92
Original site: B1MC92 
ID   UVRC_MYCA9              Reviewed;         671 AA.
AC   B1MC92;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   19-FEB-2014, entry version 48.
DE   RecName: Full=UvrABC system protein C;
DE            Short=Protein UvrC;
DE   AltName: Full=Excinuclease ABC subunit C;
GN   Name=uvrC; OrderedLocusNames=MAB_2784c;
OS   Mycobacterium abscessus (strain ATCC 19977 / DSM 44196).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium abscessus.
OX   NCBI_TaxID=561007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19977 / DSM 44196;
RG   Genoscope;
RA   Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M.,
RA   Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L.,
RA   Gaillard J.L.;
RT   "Acquisition of foreign virulence genes by the cystic fibrosis
RT   pathogen Mycobacterium abscessus.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides
CC       of the lesion. The N-terminal half is responsible for the 3'
CC       incision and the C-terminal half is responsible for the 5'
CC       incision (By similarity).
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the UvrC family.
CC   -!- SIMILARITY: Contains 1 GIY-YIG domain.
CC   -!- SIMILARITY: Contains 1 UVR domain.
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DR   EMBL; CU458896; CAM62863.1; -; Genomic_DNA.
DR   RefSeq; YP_001703517.1; NC_010397.1.
DR   ProteinModelPortal; B1MC92; -.
DR   STRING; 561007.MAB_2784c; -.
DR   EnsemblBacteria; CAM62863; CAM62863; MAB_2784c.
DR   GeneID; 5965292; -.
DR   KEGG; mab:MAB_2784c; -.
DR   PATRIC; 17977306; VBIMycAbs55940_2830.
DR   eggNOG; COG0322; -.
DR   HOGENOM; HOG000279962; -.
DR   KO; K03703; -.
DR   OMA; QKLFPIR; -.
DR   OrthoDB; EOG6K13R9; -.
DR   BioCyc; MABS561007:GJTG-2797-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0000737; P:DNA catabolic process, endonucleolytic; IEA:GOC.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   Gene3D; 4.10.860.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR027299; GIY-YIG_dom.
DR   InterPro; IPR000305; GIY-YIG_SF.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_homol_region.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA damage; DNA excision; DNA repair;
KW   Excision nuclease; SOS response.
FT   CHAIN         1    671       UvrABC system protein C.
FT                                /FTId=PRO_1000099501.
FT   DOMAIN       16     95       GIY-YIG.
FT   DOMAIN      208    243       UVR.
SQ   SEQUENCE   671 AA;  74201 MW;  985958B916FAD880 CRC64;
     MPDPSTYRPA PGSIPVEPGV YRFRDPHGRV IYVGKAKSLR SRLTSYFADI TGLHPRTRQM
     VTTAGSVEWT VVGTEVEALQ LEYNWIKEFD PRFNVRYRDD KSYPVLAVTL NEEYPRLFVY
     RGPRRKGVRY FGPYSHAWAI RETLDLLTRV FPARTCSNGV FKRHKQIDRP CLLGYIEKCS
     APCIGRVSAQ EHREIVLDFC DFLSGKTDRL ARDMEREMNQ AAQELNFERA ARLRDNISAL
     QRALERQTVV FGDGTDADVV AFSDDELEAA VQVFHVRGGR VRGQRGWIVE KTGDPGDSDL
     QGLVEQFLTQ FYGDQADLVY AADTEADVAP VPREVLVPVL PRDAEGMTSW LTGLRGSRVS
     LRVPQRGDKK ALAETVERNA KEALAQHKLK RAGDLTTRSA ALQELQDALG LEQAPLRIEC
     IDISHVQGTD VVASLVVFED GLSRRSDYRH YSIREAAGDG RSDDVASIAE VTRRRFARHV
     QDQQAVTEYA AEGHSRKFAY PPNLFVVDGG APQVNAAAAE LSELGVTDVA VIGLAKRLEE
     VWVPGEPDPV ILPRTSEALY LLQRVRDEAH RFAITFHRSK RSRRMTASVL DGIPGLGEAR
     RAALVSHFGS VAQLKKASVE EITAVPGIGA ATAVAVREAL IETDSSAPSS GATEAVLPAM
     VENGVDDTPS T
//
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