ID B1P272_9HIV1 Unreviewed; 345 AA.
AC B1P272;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ACB11923.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ACB11923.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACB11923.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B {ECO:0000313|EMBL:ACB11923.1};
RX PubMed=18419549; DOI=10.1086/587693;
RA Svicher V., Aquaro S., D'Arrigo R., Artese A., Dimonte S., Alcaro S.,
RA Santoro M.M., Di Perri G., Lo Caputo S., Bellagamba R., Zaccarelli M.,
RA Visco-Comandini U., Antinori A., Narciso P., Ceccherini-Silberstein F.,
RA Perno C.F.;
RT "Specific enfuvirtide-associated mutational pathways in HIV-1 Gp41 are
RT significantly correlated with an increase in CD4(+) cell count, despite
RT virological failure.";
RL J. Infect. Dis. 197:1408-1418(2008).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; EU251304; ACB11923.1; -; Genomic_RNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:ACB11923.1};
KW Virion {ECO:0000313|EMBL:ACB11923.1}.
FT TRANSMEM 167..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..208
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 207..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT UNSURE 163
FT /note="D or N"
FT /evidence="ECO:0000313|EMBL:ACB11923.1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACB11923.1"
SQ SEQUENCE 345 AA; 39666 MW; B4352FBF61063012 CRC64;
AVGIGAMFLG FLGAAGSTMG AASITLTAQA RTLLSGIVQQ QNNLLKAIEA QQRLLQLTVW
GIKQLQARVL AVERYLKDQQ LXGIWGCSGK LICTTAVPWN TSWSNKTLDQ IWENMTWMEW
EREIDNYTSE IYTLIEKSQN QQAKNELELL ELDKWSSLWN WFDIXNWLWY IRIFIMIVGG
LIGLRIXFSV LSIVNRVRQG YSPLSFQTRR PARRGPDRPE GIAEEGGEQD RDTSSPLVDG
FLAIIWVDLR XLFLFXYHRL RDLLLIVTRI VELLGRRGWE ALKYWWNLLQ YWSQELKNSA
VSLLNATAIA VAEGTDRVIE IAQRAWRAFL NIPTRIRQGL ERALL
//
