ID B1T881_9BURK Unreviewed; 945 AA.
AC B1T881;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=BamMEX5DRAFT_3997 {ECO:0000313|EMBL:EDT40218.1};
OS Burkholderia ambifaria MEX-5.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=396597 {ECO:0000313|EMBL:EDT40218.1, ECO:0000313|Proteomes:UP000004814};
RN [1] {ECO:0000313|EMBL:EDT40218.1, ECO:0000313|Proteomes:UP000004814}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MEX-5 {ECO:0000313|EMBL:EDT40218.1,
RC ECO:0000313|Proteomes:UP000004814};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Larimer F., Land M.L., Hauser L.,
RA Tiedje J., Richardson P.;
RT "Sequencing of the draft genome and assembly of Burkholderia ambifaria MEX-
RT 5.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDT40218.1}.
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DR EMBL; ABLK01000139; EDT40218.1; -; Genomic_DNA.
DR RefSeq; WP_006759841.1; NZ_ABLK01000139.1.
DR AlphaFoldDB; B1T881; -.
DR PATRIC; fig|396597.7.peg.3872; -.
DR Proteomes; UP000004814; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF13492; GAF_3; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ion channel {ECO:0000313|EMBL:EDT40218.1};
KW Ion transport {ECO:0000313|EMBL:EDT40218.1};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EDT40218.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000313|EMBL:EDT40218.1};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 411..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 685..917
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REGION 916..945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 945 AA; 103245 MW; F64506F13EA56376 CRC64;
MNRPDPDQLL DKLQRDEEKQ RRGQLKIFFG ASAGVGKTYA MLQAARQRLQ DGVDVVVGIV
ETHGRGETAA LLDGLDVLPL ARIDHRGRTL AEFDLDGALA RAPQLILVDE LAHSNVPGAR
HLKRWQDVYE LLDAGIDVYT TVNVQHLESL NDVVGAITGI RVWETVPDRV FDAADEVTLV
DLPAEELLER MRDGKVYLAQ QAERAVRNFF RKGNLIALRE LALRRTADRV DAQMREYRAD
RSIQRIWQAR ERLLVCVGPG PEAPTLVRAA ARLAASVKAD WIAVYVETPR LQRLPDARRQ
RTLDALKLAA ELGAETATLA GDDAVAALIG YAKVRNVSKI VAGGSPKVGL ARRFARPFGE
KLAERAGDVD LMLIRASASD EVRAAPLDAR ARDWRDAFAQ FGTRRSPPRH YLYAAAICAA
ITGVASIVSA RLDLTNLVML YLLGVVFSAV RLGRGPGVLQ SFLSVAAFDF FFVPPRMSFS
VSDTQYLLTF FGMLLTSLVI SHLTSTLTRQ ASVAQHRERR TGAIYAMARE LGAALTTEQI
VEIGSRHVGE VFRARVAFLL PDSADQVRQK IEEPDAAVTL TGADLDSDVG QWVYDQQKPA
GRGTDTLPAT TALYLPLKAP MRTRGVLAVA SREPRELEVP EQLRMLDAFA AQIALALERV
HYVEIARDAL VNMESERLRN SLLSAISHDL RTPLTTIVGF SSMLANARAA APHTPAAERS
AQREGELVDA IHDEALRMTG IVTNLLDMAR LQAGSVQLKR EWSLLEETVG AALAACKRVL
AHHPARVLLP ADLPLLQMDA VLMERLFTNL FENAAKYTPA DTPIDIGAQR VTDDGRPFVR
VHVDDHGPGL PSGMETRIFD KFTRGEKESA TPGIGLGLAI CRAIVEAHGG RIGALNRTGP
DGRVTGARFW FTLPVDTPPA APAAPDDDLD VPGAPSPSEP LPDHE
//
