ID B1VKL3_STRGG Unreviewed; 489 AA.
AC B1VKL3;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=SGR_15t {ECO:0000313|EMBL:BAG16844.1}, SGR_7124t
GN {ECO:0000313|EMBL:BAG23951.1};
OS Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG16844.1, ECO:0000313|Proteomes:UP000001685};
RN [1] {ECO:0000313|EMBL:BAG16844.1, ECO:0000313|Proteomes:UP000001685}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685}, and
RC NBRC 13350 {ECO:0000313|EMBL:BAG16844.1};
RX PubMed=18375553; DOI=10.1128/JB.00204-08;
RA Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA Yamashita A., Hattori M., Horinouchi S.;
RT "Genome sequence of the streptomycin-producing microorganism Streptomyces
RT griseus IFO 13350.";
RL J. Bacteriol. 190:4050-4060(2008).
RN [2] {ECO:0000313|EMBL:BAG16844.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NBRC 13350 {ECO:0000313|EMBL:BAG16844.1};
RX PubMed=18364359; DOI=10.1074/jbc.M710461200;
RA Funabashi M., Funa N., Horinouchi S.;
RT "Phenolic lipids synthesized by type III polyketide synthase confer
RT penicillin resistance on Streptomyces griseus.";
RL J. Biol. Chem. 283:13983-13991(2008).
RN [3] {ECO:0000313|EMBL:BAG16844.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NBRC 13350 {ECO:0000313|EMBL:BAG16844.1};
RA Hirano S., Tanaka K., Ohnishi Y., Horinouchi S.;
RT "Conditionally positive effect of the TetR-family transcriptional regulator
RT AtrA on streptomycin production by Streptomyces griseus.";
RL Microbiology (Mosc.) 154:905-914(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; AP009493; BAG16844.1; -; Genomic_DNA.
DR EMBL; AP009493; BAG23951.1; -; Genomic_DNA.
DR RefSeq; WP_012377431.1; NC_010572.1.
DR AlphaFoldDB; B1VKL3; -.
DR GeneID; 6213241; -.
DR KEGG; sgr:SGR_15t; -.
DR KEGG; sgr:SGR_7124t; -.
DR PATRIC; fig|455632.4.peg.14; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_023291_2_0_11; -.
DR Proteomes; UP000001685; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF30; F-BOX DNA HELICASE 1; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 4..279
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT REGION 429..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 25..32
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 489 AA; 53587 MW; 852C4C37222909B5 CRC64;
MPAPTDEQTA AADRFHAGDH LALQAGAGTG KTSTLALLAH STRRRGRYIA YNKAIAQEAA
TRFPSTVTCK TAHALAYAAV GHRYRTRLNS PRQPSWKTGH HLGITKTLRI GDRDLSPRAL
SYATLRTLTR FCHSADPALT DHHVPRLRNL EDAGHHRELT ALVMPFARTA WADLQNPDAG
AVRFDHDHYL KIWALTEPAI PADFFLLDEA QDTNPVVEQV FNAQRNHAQL VMVGDSAQAI
YQWRGARDVM TAFRGTGLTL SRSFRFGPDL AAEANRWLSI ATAPLRLAGT DTIPTTLGPV
DQPDAILCRT NVGAMREVMQ LLDTGHRVAL TGGGESLQAL TRAADDLRAG RRTFHPELLL
FSTWGDLQDY AANDPAGRDL QPLVDLVDTH GTEAILNAVH RLDPESTADV TVSTAHKSKG
REWASVKIAD DFTPPRDTDK KDDHGRPIPG RVDEAEARLA YVAVTRARHR LDLGGLSWIN
DHPDGTPPA
//
