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Database: UniProt
Entry: B1WAU7_XENTR
LinkDB: B1WAU7_XENTR
Original site: B1WAU7_XENTR 
ID   B1WAU7_XENTR            Unreviewed;       498 AA.
AC   B1WAU7;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   22-JUL-2015, entry version 52.
DE   RecName: Full=Serine/threonine-protein kinase receptor {ECO:0000256|RuleBase:RU361271};
DE            EC=2.7.11.30 {ECO:0000256|RuleBase:RU361271};
DE   Flags: Fragment;
GN   Name=tgfbr1 {ECO:0000313|EMBL:AAI61506.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI61506.1};
RN   [1] {ECO:0000313|EMBL:AAI61506.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Whole embryo {ECO:0000313|EMBL:AAI61506.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-
CC       protein] phosphate. {ECO:0000256|RuleBase:RU361271,
CC       ECO:0000256|SAAS:SAAS00138157}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|RuleBase:RU361271};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|RuleBase:RU361271};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU361271};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU361271}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC       {ECO:0000256|RuleBase:RU361271}.
CC   -!- SIMILARITY: Contains 1 GS domain. {ECO:0000256|RuleBase:RU361271}.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC       {ECO:0000256|RuleBase:RU361271}.
CC   -!- SIMILARITY: Contains protein kinase domain.
CC       {ECO:0000256|SAAS:SAAS00138234}.
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DR   EMBL; BC161506; AAI61506.1; -; mRNA.
DR   UniGene; Str.42236; -.
DR   STRING; 8364.ENSXETP00000050561; -.
DR   KEGG; xtr:548715; -.
DR   eggNOG; COG0515; -.
DR   HOVERGEN; HBG054502; -.
DR   KO; K04674; -.
DR   Reactome; REACT_273983; TGF-beta receptor signaling activates SMADs.
DR   Reactome; REACT_296114; Downregulation of TGF-beta receptor signaling.
DR   Reactome; REACT_326432; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
DR   Bgee; B1WAU7; -.
DR   ExpressionAtlas; B1WAU7; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004702; F:receptor signaling protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR000472; TFB_recept_I/II_C.
DR   InterPro; IPR003605; TGF_beta_rcpt_GS.
DR   InterPro; IPR000333; TGFB_receptor.
DR   PANTHER; PTHR23255; PTHR23255; 1.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   PRINTS; PR00653; ACTIVIN2R.
DR   SMART; SM00467; GS; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|RuleBase:RU361271,
KW   ECO:0000256|SAAS:SAAS00138218};
KW   Kinase {ECO:0000256|RuleBase:RU361271, ECO:0000256|SAAS:SAAS00138139};
KW   Magnesium {ECO:0000256|RuleBase:RU361271};
KW   Manganese {ECO:0000256|RuleBase:RU361271};
KW   Membrane {ECO:0000256|RuleBase:RU361271,
KW   ECO:0000256|SAAS:SAAS00138203};
KW   Metal-binding {ECO:0000256|RuleBase:RU361271};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU361271,
KW   ECO:0000256|SAAS:SAAS00138212};
KW   Receptor {ECO:0000256|RuleBase:RU361271,
KW   ECO:0000256|SAAS:SAAS00138179};
KW   Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU361271,
KW   ECO:0000256|SAAS:SAAS00138186};
KW   Transferase {ECO:0000256|RuleBase:RU361271,
KW   ECO:0000256|SAAS:SAAS00138167};
KW   Transmembrane {ECO:0000256|RuleBase:RU361271,
KW   ECO:0000256|SAAS:SAAS00138220};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361271,
KW   ECO:0000256|SAAS:SAAS00138163}.
FT   TRANSMEM    121    143       Helical. {ECO:0000256|RuleBase:RU361271}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:AAI61506.1}.
SQ   SEQUENCE   498 AA;  55998 MW;  076A7DD8B4ED09CE CRC64;
     SISSPCLRLP RLIVLLLIAL ARWAEALICH CEQCANRTCM TDGLCLVNVL IQDGKVTHNS
     LCIADSERVP RDRPFMCFST STNGIYHNVE CCQTDFCNKK LPAPSTSPSP RPPTNLGPVE
     LAAVIAGPVC LVCILLMLVL YICHNRTVIH HRVPNDEDPS LDRPFISEGT TLKDLIYDMT
     TSGSGSGLPL LVQRTIARTI VLQESIGKGR FGEVWRGKWR GEEVAVKIFS SREERSWFRE
     AEIYQTVMLR HENILGFIAA DNKDNGTWTQ LWLVSDYHEH GSLFDYLNRY TVTVEGMLKL
     SLSTASGLAH LHMEIVGTQG KPAIAHRDLK SKNILVKKNG TCCIADLGLA VRHDSATDTI
     DIAPNHRVGT KRYMAPEVLD DSINMKHFES FKRADIYAMG LVFWEIARRC SIGGIHEDYQ
     LPYYDLVPSD PSVEEMKKVV CEQKLRPNIP NRWQSCEALR VMAKIMRECW YANGAARLTA
     LRIKKTLSQL SQQEGLKM
//
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