ID B1WB60_XENTR Unreviewed; 757 AA.
AC B1WB60;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313|RefSeq:NP_001116923.1};
DE SubName: Full=Apbb2 protein {ECO:0000313|EMBL:AAI61628.1};
GN Name=apbb2 {ECO:0000313|EMBL:AAI61628.1,
GN ECO:0000313|RefSeq:NP_001116923.1,
GN ECO:0000313|Xenbase:XB-GENE-491743};
GN Synonyms=fe65l {ECO:0000313|RefSeq:NP_001116923.1}, fe65l1
GN {ECO:0000313|RefSeq:NP_001116923.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI61628.1};
RN [1] {ECO:0000313|RefSeq:NP_001116923.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI61628.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI61628.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001116923.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BC161628; AAI61628.1; -; mRNA.
DR RefSeq; NP_001116923.1; NM_001123451.1.
DR GeneID; 100144693; -.
DR KEGG; xtr:100144693; -.
DR AGR; Xenbase:XB-GENE-491743; -.
DR CTD; 323; -.
DR Xenbase; XB-GENE-491743; apbb2.
DR OMA; NVPHADD; -.
DR OrthoDB; 5404780at2759; -.
DR Proteomes; UP000008143; Chromosome 1.
DR GO; GO:0001540; F:amyloid-beta binding; IEA:InterPro.
DR CDD; cd01272; PTB1_Fe65; 1.
DR CDD; cd01271; PTB2_Fe65; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039576; APBB1/2/3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR14058; AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B; 1.
DR PANTHER; PTHR14058:SF11; AMYLOID BETA PRECURSOR PROTEIN BINDING FAMILY B MEMBER 2; 1.
DR Pfam; PF00640; PID; 2.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00462; PTB; 2.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS01179; PID; 2.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 288..320
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 417..566
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 589..714
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 200..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 83780 MW; 443F510F27EECEC1 CRC64;
MSEVLQVDSS VETLPVFMAS HSATDIVNRN AVSPPNTLNL RSSHNELLNT DIKHVETKSI
TPPKCRKKYA LTNIQAAMGL SDPASQPLLG NSSPNIKFVK NGENQLRKAA ENGNGNQDQN
KNMSLEDTVN RISEKLEGKE EIPDDSESSE ILPLIPRRTK SFLNYYADLD LSIDLEQSNG
HVVEEEDSTW INIQEPDILT NGDLLPPKQN NISSPEDSQG PTVSSSPETK KDHPKTGAKT
DCALHRIQNL APSDEDSSWT TLSQDSASPV SPDETADIWS DHSFQTDPDL PPGWKKINDI
AGIYYWHIPT GATQWERPES APTDLPASRK GSLSSITSTP TPENEKQPWS DFAVLKGGKI
NVDIWKDLHA ATVNPDPSLK EFEGATLRYA SLKLRNVPQS DEDDSSSINS DPEAKCFAVR
SLGWVEMAEE DLAPGKSSVA VNNCIRQLSY SKNDIRDTVG IWGEGKDMYL ILENDMLNLV
DPMDRTLLHS QPIVSIRVWG VGRDNGRERD FAYVARDKDT RILKCHVFRC DTPAKAIATS
LHEICSKIMA ERKNAKATAC SSMQERPHAS LDVPLQVEFP TPKTELVQKF HVQYMGMTAV
SKPIGIDILN EAIESLLNPS VKESWTPVIM NVADATVTVI KEKDEEVIVE CRVRFLSFMG
VGKDIHTFAF IMDTGSQHFE THVFWCEPNA GSVSEAVQAA CMLRYQKCLV ARPPSQKAQP
PPPPSDSVTR RVTTSVKRGV LSLIDTLKQK RPVADMP
//
