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Database: UniProt
Entry: B1WBS3
LinkDB: B1WBS3
Original site: B1WBS3 
ID   ZBT42_RAT               Reviewed;         420 AA.
AC   B1WBS3;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   29-OCT-2014, entry version 54.
DE   RecName: Full=Zinc finger and BTB domain-containing protein 42;
GN   Name=Zbtb42;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transcriptional repressor. Specifically binds DNA and
CC       probably acts by recruiting chromatin remodeling multiprotein
CC       complexes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus,
CC       nucleoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. ZBTB18 subfamily. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 BTB (POZ) domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00037}.
CC   -!- SIMILARITY: Contains 4 C2H2-type zinc fingers.
CC       {ECO:0000255|PROSITE-ProRule:PRU00042}.
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DR   EMBL; BC161864; AAI61864.1; -; mRNA.
DR   RefSeq; NP_001119774.1; NM_001126302.1.
DR   UniGene; Rn.190797; -.
DR   ProteinModelPortal; B1WBS3; -.
DR   PRIDE; B1WBS3; -.
DR   Ensembl; ENSRNOT00000030879; ENSRNOP00000035859; ENSRNOG00000037562.
DR   GeneID; 691556; -.
DR   KEGG; rno:691556; -.
DR   UCSC; RGD:1582758; rat.
DR   CTD; 100128927; -.
DR   RGD; 1582758; Zbtb42.
DR   eggNOG; COG5048; -.
DR   GeneTree; ENSGT00760000118922; -.
DR   HOGENOM; HOG000234147; -.
DR   HOVERGEN; HBG059113; -.
DR   InParanoid; B1WBS3; -.
DR   OMA; ICPLCCK; -.
DR   OrthoDB; EOG7SV0VF; -.
DR   PhylomeDB; B1WBS3; -.
DR   TreeFam; TF337437; -.
DR   NextBio; 743302; -.
DR   Genevestigator; B1WBS3; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.160.60; -; 3.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ-like.
DR   InterPro; IPR011333; BTB/POZ_fold.
DR   InterPro; IPR013069; BTB_POZ.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    420       Zinc finger and BTB domain-containing
FT                                protein 42.
FT                                /FTId=PRO_0000343712.
FT   DOMAIN       24     92       BTB. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00037}.
FT   ZN_FING     292    314       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     332    354       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     360    382       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     388    411       C2H2-type 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
SQ   SEQUENCE   420 AA;  46628 MW;  4FFA4279B16B1EF5 CRC64;
     MEFPEHGVRL LGRLRQQREL GFLCDCTVLV GDARFPAHRA VLAACSVYFH LFYRDQPASS
     RDTVRLNGDI VTVPAFSRLL DFMYEGRLDL HSLPVEDVLA AASYLHMYDI VKVCKGRLRK
     KDPDLETRTL GTELPGQTPH PLPSWPPAFC QATPKAKPPS LGVKAVHPLP KFGPPSWQVS
     EESSGALDLS LKPGPRPEQA HPPCLLQTSQ CSSIQQGAQP LVKAEQDSFS EQDSSSPQSA
     DRSPPPVCAS AARGLAVNLE PLHIQGTGSQ QLGLHAEPVV DSEDLGPGRH LCICPLCCKL
     FPSTHALQPH LSAHFRERDS VRTRLSPEGA VPTCPLCSKT FSCTYTLKRH ERTHSGEKPY
     TCVQCGKSFQ YSHNLSRHAV VHTREKPHAC RWCERRFTQS GDLYRHVRKF HYGLVKPLLV
//
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