ID ZBT42_RAT Reviewed; 420 AA.
AC B1WBS3;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 1.
DT 01-MAY-2013, entry version 44.
DE RecName: Full=Zinc finger and BTB domain-containing protein 42;
GN Name=Zbtb42;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcriptional repressor. Specifically binds DNA and
CC probably acts by recruiting chromatin remodeling multiprotein
CC complexes (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus,
CC nucleoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. ZBTB18 subfamily.
CC -!- SIMILARITY: Contains 1 BTB (POZ) domain.
CC -!- SIMILARITY: Contains 4 C2H2-type zinc fingers.
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DR EMBL; BC161864; AAI61864.1; -; mRNA.
DR IPI; IPI00369685; -.
DR RefSeq; NP_001119774.1; NM_001126302.1.
DR UniGene; Rn.190797; -.
DR ProteinModelPortal; B1WBS3; -.
DR PRIDE; B1WBS3; -.
DR Ensembl; ENSRNOT00000030879; ENSRNOP00000035859; ENSRNOG00000037562.
DR GeneID; 691556; -.
DR KEGG; rno:691556; -.
DR UCSC; RGD:1582758; rat.
DR CTD; 100128927; -.
DR RGD; 1582758; Zbtb42.
DR eggNOG; COG5048; -.
DR GeneTree; ENSGT00680000099682; -.
DR HOGENOM; HOG000234147; -.
DR HOVERGEN; HBG059113; -.
DR OrthoDB; EOG4NZTTM; -.
DR NextBio; 743302; -.
DR Genevestigator; B1WBS3; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 3.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ-like.
DR InterPro; IPR011333; BTB/POZ_fold.
DR InterPro; IPR013069; BTB_POZ.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF54695; BTB/POZ_fold; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 420 Zinc finger and BTB domain-containing
FT protein 42.
FT /FTId=PRO_0000343712.
FT DOMAIN 24 92 BTB.
FT ZN_FING 292 314 C2H2-type 1.
FT ZN_FING 332 354 C2H2-type 2.
FT ZN_FING 360 382 C2H2-type 3.
FT ZN_FING 388 411 C2H2-type 4.
SQ SEQUENCE 420 AA; 46628 MW; 4FFA4279B16B1EF5 CRC64;
MEFPEHGVRL LGRLRQQREL GFLCDCTVLV GDARFPAHRA VLAACSVYFH LFYRDQPASS
RDTVRLNGDI VTVPAFSRLL DFMYEGRLDL HSLPVEDVLA AASYLHMYDI VKVCKGRLRK
KDPDLETRTL GTELPGQTPH PLPSWPPAFC QATPKAKPPS LGVKAVHPLP KFGPPSWQVS
EESSGALDLS LKPGPRPEQA HPPCLLQTSQ CSSIQQGAQP LVKAEQDSFS EQDSSSPQSA
DRSPPPVCAS AARGLAVNLE PLHIQGTGSQ QLGLHAEPVV DSEDLGPGRH LCICPLCCKL
FPSTHALQPH LSAHFRERDS VRTRLSPEGA VPTCPLCSKT FSCTYTLKRH ERTHSGEKPY
TCVQCGKSFQ YSHNLSRHAV VHTREKPHAC RWCERRFTQS GDLYRHVRKF HYGLVKPLLV
//
