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Database: UniProt
Entry: B1XE36
LinkDB: B1XE36
Original site: B1XE36 
ID   ECPR_ECODH              Reviewed;         196 AA.
AC   B1XE36;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   01-OCT-2014, entry version 53.
DE   RecName: Full=HTH-type transcriptional regulator EcpR;
GN   Name=ecpR; Synonyms=matA; OrderedLocusNames=ECDH10B_0282;
OS   Escherichia coli (strain K12 / DH10B).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=316385;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / DH10B;
RX   PubMed=18245285; DOI=10.1128/JB.01695-07;
RA   Durfee T., Nelson R., Baldwin S., Plunkett G. III, Burland V., Mau B.,
RA   Petrosino J.F., Qin X., Muzny D.M., Ayele M., Gibbs R.A., Csorgo B.,
RA   Posfai G., Weinstock G.M., Blattner F.R.;
RT   "The complete genome sequence of Escherichia coli DH10B: insights into
RT   the biology of a laboratory workhorse.";
RL   J. Bacteriol. 190:2597-2606(2008).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli
CC       common pilus (ECP). ECP is found in both commensal and pathogenic
CC       strains and plays a dual role in early-stage biofilm development
CC       and host cell recognition. Positively regulates the expression of
CC       the ecp operon (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively autoregulated.
CC       Also positively regulated by IHF (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EcpR/MatA family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 HTH luxR-type DNA-binding domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00411}.
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DR   EMBL; CP000948; ACB01460.1; -; Genomic_DNA.
DR   RefSeq; YP_001729238.1; NC_010473.1.
DR   ProteinModelPortal; B1XE36; -.
DR   SMR; B1XE36; 143-195.
DR   STRING; 316385.ECDH10B_0282; -.
DR   EnsemblBacteria; ACB01460; ACB01460; ECDH10B_0282.
DR   GeneID; 6058216; -.
DR   KEGG; ecd:ECDH10B_0282; -.
DR   PATRIC; 18460320; VBIEscCol59506_0278.
DR   eggNOG; COG2771; -.
DR   HOGENOM; HOG000059412; -.
DR   OMA; HPKSIAR; -.
DR   OrthoDB; EOG69GZGV; -.
DR   BioCyc; ECOL316385:GJ8B-278-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   Activator; Complete proteome; Cytoplasm; DNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    196       HTH-type transcriptional regulator EcpR.
FT                                /FTId=PRO_0000369174.
FT   DOMAIN      138    196       HTH luxR-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00411}.
FT   DNA_BIND    162    181       H-T-H motif. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00411}.
SQ   SEQUENCE   196 AA;  23274 MW;  5A3676E17E9793B9 CRC64;
     MTWQSDYSRD YEVKNHMECQ NRSDKYIWSP HDAYFYKGLS ELIVDIDRLI YLSLEKIRKD
     FVFINLSTDS LSEFINRDNE WLSAVKGKQV VLIAARKSEA LANYWYYNSN IRGVVYAGLS
     RDIRKELVYV INGRFLRKDI KKDKITDREM EIIRMTAQGM QPKSIARIEN CSVKTVYTHR
     RNAEAKLYSK IYKLVQ
//
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