ID B1XXA5_LEPCP Unreviewed; 700 AA.
AC B1XXA5;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Flagellar biosynthesis protein FlhA {ECO:0000256|RuleBase:RU364093};
DE Flags: Precursor;
GN Name=flhA {ECO:0000256|RuleBase:RU364093};
GN OrderedLocusNames=Lcho_1619 {ECO:0000313|EMBL:ACB33886.1};
OS Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix
OS discophora (strain SP-6)).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Leptothrix.
OX NCBI_TaxID=395495 {ECO:0000313|EMBL:ACB33886.1, ECO:0000313|Proteomes:UP000001693};
RN [1] {ECO:0000313|EMBL:ACB33886.1, ECO:0000313|Proteomes:UP000001693}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51168 / LMG 8142 / SP-6
RC {ECO:0000313|Proteomes:UP000001693};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Lykidis A., Emerson D., Richardson P.;
RT "Complete sequence of Leptothrix cholodnii SP-6.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin. {ECO:0000256|RuleBase:RU364093}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU364093};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU364093}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000256|ARBA:ARBA00008835,
CC ECO:0000256|RuleBase:RU364093}.
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DR EMBL; CP001013; ACB33886.1; -; Genomic_DNA.
DR RefSeq; WP_012346647.1; NC_010524.1.
DR AlphaFoldDB; B1XXA5; -.
DR STRING; 395495.Lcho_1619; -.
DR KEGG; lch:Lcho_1619; -.
DR eggNOG; COG1298; Bacteria.
DR HOGENOM; CLU_015346_3_0_4; -.
DR OrthoDB; 9759185at2; -.
DR Proteomes; UP000001693; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR025505; FHIPEP_CS.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR NCBIfam; TIGR01398; FlhA; 1.
DR PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
DR PROSITE; PS00994; FHIPEP; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|RuleBase:RU364093};
KW Bacterial flagellum protein export {ECO:0000256|RuleBase:RU364093};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU364093};
KW Cell projection {ECO:0000313|EMBL:ACB33886.1};
KW Cilium {ECO:0000313|EMBL:ACB33886.1};
KW Flagellum {ECO:0000313|EMBL:ACB33886.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364093};
KW Protein transport {ECO:0000256|RuleBase:RU364093};
KW Reference proteome {ECO:0000313|Proteomes:UP000001693};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364093};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364093}; Transport {ECO:0000256|RuleBase:RU364093}.
FT TRANSMEM 21..44
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 50..69
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 121..144
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 213..234
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 246..272
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 293..309
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
SQ SEQUENCE 700 AA; 74758 MW; 6DFD422F88ECFC14 CRC64;
MNLSNVPQLR QLQRLFGANT AAIKGLAAPI LIIMVLAMMV LPLPAFALDL FFTFNIATAL
LVMMVAAYMV RPLDFAAFPS VLLLTTLLRL SLNVASSRVV LMDGHNGPGA AGAVIESFGH
FLIGGNFAVG LIVFAIVVVI NFMVITKGAE RIAEVGARFT LDAMPGKQMA IDADLNAGNI
DEKEAKRRRI EVQEEAEFFG SMDGASKFVR GDAVAGILIL FINIVGGFII GMAQHGLGAG
EAASSYILLA VGDALVAQIP ALLISVASAM VVSRVGKEQD VGNQIMGQMF RSPQSVAVVA
GVIGLLGMIP GMPHLVFLMI AGGMAALSRW MYREAKKPKP VEAPADVVAP ANPNAEASWD
DLLPVDTLGM EVGYRLIALV DKDRGGDLLN RIKGVRKKFA QEVGFLPPAV HIRDNLELKP
SMYRLTLRGA VVGEGEAFPG MHLAINPGHA TLKLQGATTT DPAFGLPATW IDERQRESAQ
MAGYTVVDSS TVVATHLSHL MQQHAARLLG RTETQALVEH VTKLAPKLIE DVVPKMIGIA
PLQKVLQLLL EEGVHIRDMR SIIEALAEHA GNNVDPAELA RRLRIALAPA IVQQIYGSAR
ELDVIAIEPD LERLLSQALN AHNGAVLDPG VADHLTRGAA DAARRQEDLG HPACLLVPDP
IRSPVARLLR RAAPRLRVLG HSEIPDTHSI RIGSIIGANA
//
