ID B1Y0E2_LEPCP Unreviewed; 634 AA.
AC B1Y0E2;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:ACB36621.1};
GN OrderedLocusNames=Lcho_4370 {ECO:0000313|EMBL:ACB36621.1};
OS Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix
OS discophora (strain SP-6)).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Leptothrix.
OX NCBI_TaxID=395495 {ECO:0000313|EMBL:ACB36621.1, ECO:0000313|Proteomes:UP000001693};
RN [1] {ECO:0000313|EMBL:ACB36621.1, ECO:0000313|Proteomes:UP000001693}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51168 / LMG 8142 / SP-6
RC {ECO:0000313|Proteomes:UP000001693};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Lykidis A., Emerson D., Richardson P.;
RT "Complete sequence of Leptothrix cholodnii SP-6.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP001013; ACB36621.1; -; Genomic_DNA.
DR RefSeq; WP_012349362.1; NC_010524.1.
DR AlphaFoldDB; B1Y0E2; -.
DR STRING; 395495.Lcho_4370; -.
DR KEGG; lch:Lcho_4370; -.
DR eggNOG; COG1032; Bacteria.
DR HOGENOM; CLU_018720_0_0_4; -.
DR OrthoDB; 9801424at2; -.
DR Proteomes; UP000001693; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409:SF7; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001693}.
FT DOMAIN 136..300
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 355..571
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 634 AA; 69705 MW; 2324DEC31FA99160 CRC64;
MPSQPVRVLS VIAPMTQLNT PYPSTAYLTG FLRSRGVDAV QEDLALALAL KLLSRDGLAS
VHARIATLPA AKRTPRVQAF EADYARYAAT IAPTLAFLQG RDATLAHRIC SRAFLPEGSR
FAPLDAFEDA DGSGPLAWAF GALGAQDHAR HLATLYLNDI ADVIREAVDP RFEFVRYAES
LALSQPTFDP LADALAAPPT LVDELLRELT LAAIERHRPT LVLVSVPFPG AVYAAFRIAQ
AIKAIDPTIV TALGGGYVNT ELRELTEPRV FEHFDYLTLD AGERPLLALL EHLDGKRSQT
RLVRTFVRQD GAVKYINFVE PDVAFEDVGT PTWDGLPLDR YLSLLDMLNP MHRLWSDGRW
NKLTVAHGCY WKKCSFCDVS LDYISRYDTA SAQTLVNRIE TIVNETGQTG FHFVDEAAPP
KSLKALAAEL QRRQLGISWW GNIRFEKSFT PELCQQLADS GCIAISGGLE VASDRLLTLM
KKGVSVDQVA RVTKGFADAG ILVHAYLMYG FPTQTAQDTV DALEYVRQLF EQGCIQSGFF
HRFACTVHSP VGQAPQDYGV TLQPLPPVSF AKNDIGFIDP TGTDHDALGV GLKKALYNYM
HGIGLDEDVR AWFDFPVPKS RVGRNRIAKA LAGA
//
