ID B1Y217_LEPCP Unreviewed; 523 AA.
AC B1Y217;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Efflux transporter, RND family, MFP subunit {ECO:0000313|EMBL:ACB34316.1};
DE Flags: Precursor;
GN OrderedLocusNames=Lcho_2049 {ECO:0000313|EMBL:ACB34316.1};
OS Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix
OS discophora (strain SP-6)).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Leptothrix.
OX NCBI_TaxID=395495 {ECO:0000313|EMBL:ACB34316.1, ECO:0000313|Proteomes:UP000001693};
RN [1] {ECO:0000313|EMBL:ACB34316.1, ECO:0000313|Proteomes:UP000001693}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51168 / LMG 8142 / SP-6
RC {ECO:0000313|Proteomes:UP000001693};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Lykidis A., Emerson D., Richardson P.;
RT "Complete sequence of Leptothrix cholodnii SP-6.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP001013; ACB34316.1; -; Genomic_DNA.
DR AlphaFoldDB; B1Y217; -.
DR STRING; 395495.Lcho_2049; -.
DR KEGG; lch:Lcho_2049; -.
DR eggNOG; COG0845; Bacteria.
DR eggNOG; COG5569; Bacteria.
DR HOGENOM; CLU_018816_13_1_4; -.
DR OrthoDB; 9806939at2; -.
DR Proteomes; UP000001693; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 6.10.140.730; -; 1.
DR Gene3D; 2.40.50.320; Copper binding periplasmic protein CusF; 1.
DR InterPro; IPR021647; CusF_Ec.
DR InterPro; IPR042230; CusF_sf.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR045800; HMBD.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30097; CATION EFFLUX SYSTEM PROTEIN CUSB; 1.
DR PANTHER; PTHR30097:SF15; CATION EFFLUX SYSTEM PROTEIN CUSB; 1.
DR Pfam; PF11604; CusF_Ec; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR Pfam; PF19335; HMBD; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001693}.
FT DOMAIN 52..78
FT /note="Heavy metal binding"
FT /evidence="ECO:0000259|Pfam:PF19335"
FT DOMAIN 118..324
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 499..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 523 AA; 54902 MW; 9845EEE9B3141FBC CRC64;
MNTRLKSLVA ALMLLGLGGA AGWGISQWRT GASAQTAASD TAAPTAERKV LYWYDPMVPT
QKFDQPGKSP FMDMQLVPRY ADEADAGADS GAALAVSTQA RQALGLRLAT VEKRPIGAAI
EVVGTVQLNE RDISIVQART AGFVERVYAR APGDVIAAGA PLVDLLNPEW LGAQHEYLAV
KATGDAAMTQ AARARLVLLG MPAALIEQVE RSGQPAAVQT LVAPGGGVIS ELMVRQGMTV
SAGMTLARIN GLATVWLEAA LPEAQAATIR TGQAVEVRFP ALPGEVVRGK VAAVLPEADR
ETRTLRLRIE LPNPKQRLRA GLFAQVSLRA AQGEALMVPA EAVIRTGRRA LVYLSEQPGH
FRPVEVEIGE QFDEYIVVRS GLAAGQQVVA SGQFLVDSEA SLQGVMARSA PPAASAAVTP
VAEAPVYRTT GVVVETDSGS ITLEHAPVPA LKWPGMTMPF KVTDPKLLKG LKPGQAVRFG
FDQHGDDYRL TEIAPATAAS GSVDADPHAG HRAPAVAASG AQR
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