ID   B1Y5U9_LEPCP            Unreviewed;       720 AA.
AC   B1Y5U9;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Membrane protein with HlyD domain {ECO:0000313|EMBL:ACB35995.1};
GN   OrderedLocusNames=Lcho_3741 {ECO:0000313|EMBL:ACB35995.1};
OS   Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix
OS   discophora (strain SP-6)).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Sphaerotilaceae; Leptothrix.
OX   NCBI_TaxID=395495 {ECO:0000313|EMBL:ACB35995.1, ECO:0000313|Proteomes:UP000001693};
RN   [1] {ECO:0000313|EMBL:ACB35995.1, ECO:0000313|Proteomes:UP000001693}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51168 / LMG 8142 / SP-6
RC   {ECO:0000313|Proteomes:UP000001693};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Lykidis A., Emerson D., Richardson P.;
RT   "Complete sequence of Leptothrix cholodnii SP-6.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the peptidase M50B family.
CC       {ECO:0000256|ARBA:ARBA00007931}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001013; ACB35995.1; -; Genomic_DNA.
DR   RefSeq; WP_012348742.1; NC_010524.1.
DR   AlphaFoldDB; B1Y5U9; -.
DR   STRING; 395495.Lcho_3741; -.
DR   KEGG; lch:Lcho_3741; -.
DR   eggNOG; COG0845; Bacteria.
DR   eggNOG; COG1994; Bacteria.
DR   HOGENOM; CLU_019354_1_0_4; -.
DR   OrthoDB; 9759690at2; -.
DR   Proteomes; UP000001693; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 2.40.30.170; -; 1.
DR   InterPro; IPR001193; MBTPS2.
DR   InterPro; IPR008915; Peptidase_M50.
DR   PANTHER; PTHR13325:SF3; MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE; 1.
DR   PANTHER; PTHR13325; PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE; 1.
DR   Pfam; PF13437; HlyD_3; 1.
DR   Pfam; PF02163; Peptidase_M50; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001693};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        396..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        434..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          208..289
FT                   /note="Peptidase M50"
FT                   /evidence="ECO:0000259|Pfam:PF02163"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   720 AA;  79705 MW;  80521E4AEBD5CE95 CRC64;
     MSTLTAPPGA TFMLDAPRPP AAPAPWPALR DDLQLHHGPA LPDGQPSWTL HDPVRHRFLR
     IDWLSHEVLR HWWLRDAALI AEQISQQTTL AVEPEQVKQV LTWAVREELV LPVAPPPAGR
     SSADNPLGAV ATWLLHHYLF FRIPLFNPDR LLQRLLPWVS GLGSRRFGQL TLAALAFGLI
     GLARHAEQLQ AQWLDLLSWR GLALYGLTLT LVKVAHEFGH ALVAKHHGLR VPTMGAAFMV
     MWPVAYTDTS EAWRLADPRA RLQIAAAGVR TELTLAAWAT LAWVLLPDGG LRTAAFIVAT
     MTWVSTLLIN TSPFMRFDGY FLLCDLLDMP NLHERSFALA RWQLRRSVLG WQAEAPEALT
     PGWQRALIAF AWATWAYRLV LYLGIAWMVY HFGFPALGLL LFAVEMGWFI AAPIQRELGL
     WRQGWPRWRG AVRWIWSLLG LLLIGSLAAL PWPVRETAGA VLRPAQELAL RMPATATLRA
     LPLQPGQRIA AGTPLLMAEV PMLQRKLDSS AVRIRQLGQQ VASASLSGDQ QAQWQSLQAD
     LATARGEAAA LRQELVRYRP VAPFDALVVE VDPSLRAGMV VGPQQTLMRL ASAGPGRVLA
     YVSESAASRL KAGDRATFGA DANPLARWDA HIVNVAPHAS ATLAEPMLAR SHGGPIEARE
     QSGRWLPLQP LYRVELQLDA DPGLSPRHWR GHVVIELPGR SLWERGWTAA AEVLAREVGF
//