ID B1YFH3_EXIS2 Unreviewed; 356 AA.
AC B1YFH3;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Aromatic amino acid beta-eliminating lyase/threonine aldolase {ECO:0000313|EMBL:ACB60849.1};
GN OrderedLocusNames=Exig_1379 {ECO:0000313|EMBL:ACB60849.1};
OS Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 /
OS 255-15).
OC Bacteria; Bacillota; Bacilli; Bacillales;
OC Bacillales Family XII. Incertae Sedis; Exiguobacterium.
OX NCBI_TaxID=262543 {ECO:0000313|EMBL:ACB60849.1, ECO:0000313|Proteomes:UP000001681};
RN [1] {ECO:0000313|EMBL:ACB60849.1, ECO:0000313|Proteomes:UP000001681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17290 / CIP 109462 / JCM 13490 / 255-15
RC {ECO:0000313|Proteomes:UP000001681};
RX PubMed=16489412; DOI=10.1007/s00792-005-0497-5;
RA Rodrigues D.F., Goris J., Vishnivetskaya T., Gilichinsky D.,
RA Thomashow M.F., Tiedje J.M.;
RT "Characterization of Exiguobacterium isolates from the Siberian permafrost.
RT Description of Exiguobacterium sibiricum sp. nov.";
RL Extremophiles 10:285-294(2006).
RN [2] {ECO:0000313|EMBL:ACB60849.1, ECO:0000313|Proteomes:UP000001681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17290 / CIP 109462 / JCM 13490 / 255-15
RC {ECO:0000313|Proteomes:UP000001681};
RX PubMed=19019206; DOI=10.1186/1471-2164-9-547;
RA Rodrigues D.F., Ivanova N., He Z., Huebner M., Zhou J., Tiedje J.M.;
RT "Architecture of thermal adaptation in an Exiguobacterium sibiricum strain
RT isolated from 3 million year old permafrost: a genome and transcriptome
RT approach.";
RL BMC Genomics 9:547-547(2008).
RN [3] {ECO:0000313|Proteomes:UP000001681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17290 / CIP 109462 / JCM 13490 / 255-15
RC {ECO:0000313|Proteomes:UP000001681};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C.,
RA Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F.,
RA Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T.,
RA Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P.;
RT "Complete sequence of chromosome of Exiguobacterium sibiricum 255-15.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0007829|PDB:3LWS}
RP X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
RG Joint Center for Structural Genomics (JCSG);
RT "Crystal structure of Putative aromatic amino acid beta-eliminating
RT lyase/threonine aldolase. (YP_001813866.1) from Exiguobacterium sp. 255-15
RT at 2.00 A resolution.";
RL Submitted (FEB-2010) to the PDB data bank.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the threonine aldolase family.
CC {ECO:0000256|ARBA:ARBA00006966}.
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DR EMBL; CP001022; ACB60849.1; -; Genomic_DNA.
DR RefSeq; WP_012370270.1; NC_010556.1.
DR PDB; 3LWS; X-ray; 2.00 A; A/B/C/D/E/F=1-356.
DR PDBsum; 3LWS; -.
DR AlphaFoldDB; B1YFH3; -.
DR SMR; B1YFH3; -.
DR STRING; 262543.Exig_1379; -.
DR KEGG; esi:Exig_1379; -.
DR eggNOG; COG2008; Bacteria.
DR HOGENOM; CLU_029381_4_0_9; -.
DR OrthoDB; 9774495at2; -.
DR EvolutionaryTrace; B1YFH3; -.
DR Proteomes; UP000001681; Chromosome.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR48097:SF9; L-THREONINE ALDOLASE; 1.
DR PANTHER; PTHR48097; L-THREONINE ALDOLASE-RELATED; 1.
DR Pfam; PF01212; Beta_elim_lyase; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3LWS}; Lyase {ECO:0000313|EMBL:ACB60849.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001681}.
FT DOMAIN 37..291
FT /note="Aromatic amino acid beta-eliminating lyase/threonine
FT aldolase"
FT /evidence="ECO:0000259|Pfam:PF01212"
SQ SEQUENCE 356 AA; 39592 MW; 7872D46BC552934C CRC64;
MNRLRTSFQQ TTGQISGHGK RNVGVLKTAF AAVADEMASD QYGTGAIIEP FEQKFADVLG
MDDAVFFPSG TMAQQVALRI WSDETDNRTV AYHPLCHLEI HEQDGLKELH PIETILVGAA
DRLMTLDEIK ALPDIACLLL ELPQREIGGV APAFSELETI SRYCRERGIR LHLDGARLFE
MLPYYEKTAA EIAGLFDSIY ISFYKGLGGI AGAILAGPAA FCQTARIWKR RYGGDLISLY
PYIVSADYYY ELRKDRMGQY YEQAKQLAEQ FNALPGVHTT PEVPVSNMFH LHFDGQAADI
SPKLEQVQEE TGLGFVGYLV DKDGYCSTEI SVGDAYGELD QQTRDAGFAR LRQAFS
//
