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Database: UniProt
Entry: B1YKL6_EXIS2
LinkDB: B1YKL6_EXIS2
Original site: B1YKL6_EXIS2 
ID   B1YKL6_EXIS2            Unreviewed;       329 AA.
AC   B1YKL6;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   07-JUN-2017, entry version 65.
DE   RecName: Full=Lipoate--protein ligase {ECO:0000256|SAAS:SAAS00603724};
DE            EC=6.3.1.20 {ECO:0000256|SAAS:SAAS00603724};
GN   OrderedLocusNames=Exig_0718 {ECO:0000313|EMBL:ACB60199.1};
OS   Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15).
OC   Bacteria; Firmicutes; Bacilli; Bacillales;
OC   Bacillales Family XII. Incertae Sedis; Exiguobacterium.
OX   NCBI_TaxID=262543 {ECO:0000313|EMBL:ACB60199.1, ECO:0000313|Proteomes:UP000001681};
RN   [1] {ECO:0000313|Proteomes:UP000001681}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17290 / JCM 13490 / 255-15
RC   {ECO:0000313|Proteomes:UP000001681};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O.,
RA   Monk C., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Vishnivetskaya T., Rodrigues D.F., Gilichinsky D., Tiedje J.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Exiguobacterium sibiricum 255-
RT   15.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + (R)-lipoate + a [lipoyl-carrier
CC       protein]-L-lysine = a [lipoyl-carrier protein]-N(6)-(lipoyl)lysine
CC       + AMP + diphosphate. {ECO:0000256|SAAS:SAAS00603726}.
CC   -!- PATHWAY: Protein modification; protein lipoylation via exogenous
CC       pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.
CC       {ECO:0000256|SAAS:SAAS00701662}.
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DR   EMBL; CP001022; ACB60199.1; -; Genomic_DNA.
DR   RefSeq; WP_012369623.1; NC_010556.1.
DR   ProteinModelPortal; B1YKL6; -.
DR   STRING; 262543.Exig_0718; -.
DR   EnsemblBacteria; ACB60199; ACB60199; Exig_0718.
DR   GeneID; 31768875; -.
DR   KEGG; esi:Exig_0718; -.
DR   eggNOG; ENOG4105DF9; Bacteria.
DR   eggNOG; COG0095; LUCA.
DR   HOGENOM; HOG000260593; -.
DR   KO; K03800; -.
DR   OMA; EDWIHDH; -.
DR   OrthoDB; POG091H03KP; -.
DR   BioCyc; ESIB262543:GHBP-787-MONOMER; -.
DR   UniPathway; UPA00537; UER00595.
DR   Proteomes; UP000001681; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009249; P:protein lipoylation; IEA:InterPro.
DR   InterPro; IPR004143; BPL_LPL_catalytic.
DR   InterPro; IPR019491; Lipoate_protein_ligase_C.
DR   InterPro; IPR004562; LipoylTrfase_LipoateP_Ligase.
DR   PANTHER; PTHR12561; PTHR12561; 1.
DR   Pfam; PF03099; BPL_LplA_LipB; 1.
DR   Pfam; PF10437; Lip_prot_lig_C; 1.
DR   TIGRFAMs; TIGR00545; lipoyltrans; 1.
DR   PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00428641};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001681};
KW   Ligase {ECO:0000256|SAAS:SAAS00603725, ECO:0000313|EMBL:ACB60199.1};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00026749};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001681};
KW   Transferase {ECO:0000313|EMBL:ACB60199.1}.
FT   DOMAIN       28    215       BPL/LPL catalytic. {ECO:0000259|PROSITE:
FT                                PS51733}.
SQ   SEQUENCE   329 AA;  37641 MW;  90CE0BDE4A48FBDB CRC64;
     MKFIFHPDIH DARINLAVED FILNNLNVNE EDYFLFYING PSIIVGKNQN TSEEVNLKYI
     EENGIHVVRR LSGGGAVYHD HGNLNFSFLT KDDGDSFNNY KKFTEPVVQA LHKLGVEAEL
     SGRNDIHVGT RKISGNAQFT TKGRMFSHGT LMLDSNIEEV VNALVVSEEK MRSKGIKSVR
     SRVANISEFL TEPLTMDQFV EHLLESIYEG KEMERYVLTD EDWAKVHAIS AERYGNWDWN
     FGKSPKFDVI HKKRFPIGTI DFRLNVKKGI IEEAKIYGDF FGVEDASEIA RALEGKRYDR
     SSLREVLSQY ELKKYFGAVE LDEVLDVLA
//
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