ID B1YYG9_BURA4 Unreviewed; 680 AA.
AC B1YYG9;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Type 3 secretion system secretin {ECO:0000256|HAMAP-Rule:MF_02219};
DE Short=T3SS secretin {ECO:0000256|HAMAP-Rule:MF_02219};
DE Flags: Precursor;
GN Name=sctC {ECO:0000256|HAMAP-Rule:MF_02219};
GN OrderedLocusNames=BamMC406_4751 {ECO:0000313|EMBL:ACB67205.1};
OS Burkholderia ambifaria (strain MC40-6).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=398577 {ECO:0000313|EMBL:ACB67205.1, ECO:0000313|Proteomes:UP000001680};
RN [1] {ECO:0000313|Proteomes:UP000001680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC40-6 {ECO:0000313|Proteomes:UP000001680};
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Ramette A.,
RA Konstantinidis K., Tiedje J., Richardson P.;
RT "Complete sequence of chromosome 2 of Burkholderia ambifaria MC40-6.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the type III secretion system (T3SS), also
CC called injectisome, which is used to inject bacterial effector proteins
CC into eukaryotic host cells. Forms a ring-shaped multimeric structure
CC with an apparent central pore in the outer membrane.
CC {ECO:0000256|HAMAP-Rule:MF_02219}.
CC -!- SUBUNIT: The core secretion machinery of the T3SS is composed of
CC approximately 20 different proteins, including cytoplasmic components,
CC a base, an export apparatus and a needle. This subunit is part of the
CC base, which anchors the injectisome in the bacterial cell envelope.
CC Forms a stable homooligomeric complex. {ECO:0000256|HAMAP-
CC Rule:MF_02219}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000256|HAMAP-
CC Rule:MF_02219, ECO:0000256|RuleBase:RU004004}.
CC -!- SIMILARITY: Belongs to the bacterial secretin family. T3SS SctC
CC subfamily. {ECO:0000256|ARBA:ARBA00007032, ECO:0000256|HAMAP-
CC Rule:MF_02219}.
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DR EMBL; CP001026; ACB67205.1; -; Genomic_DNA.
DR RefSeq; WP_012366495.1; NC_010552.1.
DR AlphaFoldDB; B1YYG9; -.
DR KEGG; bac:BamMC406_4751; -.
DR HOGENOM; CLU_022474_2_0_4; -.
DR OrthoDB; 9779724at2; -.
DR Proteomes; UP000001680; Chromosome 2.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030257; C:type III protein secretion system complex; IEA:UniProtKB-UniRule.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.120; -; 2.
DR Gene3D; 3.55.50.30; -; 1.
DR HAMAP; MF_02219; Type_III_secretin; 1.
DR InterPro; IPR005644; NolW-like.
DR InterPro; IPR038591; NolW-like_sf.
DR InterPro; IPR004846; T2SS/T3SS_dom.
DR InterPro; IPR004845; T2SS_GspD_CS.
DR InterPro; IPR003522; T3SS_OM_pore_YscC.
DR NCBIfam; TIGR02516; type_III_yscC; 1.
DR PANTHER; PTHR30332; PROBABLE GENERAL SECRETION PATHWAY PROTEIN D; 1.
DR PANTHER; PTHR30332:SF5; SPI-1 TYPE 3 SECRETION SYSTEM SECRETIN; 1.
DR Pfam; PF00263; Secretin; 1.
DR Pfam; PF03958; Secretin_N; 2.
DR PRINTS; PR01337; TYPE3OMGPROT.
DR PROSITE; PS00875; T2SP_D; 1.
PE 3: Inferred from homology;
KW Cell outer membrane {ECO:0000256|HAMAP-Rule:MF_02219};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02219};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927, ECO:0000256|HAMAP-
KW Rule:MF_02219};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|HAMAP-Rule:MF_02219};
KW Translocation {ECO:0000256|ARBA:ARBA00023010, ECO:0000256|HAMAP-
KW Rule:MF_02219};
KW Transport {ECO:0000256|HAMAP-Rule:MF_02219, ECO:0000256|RuleBase:RU004004}.
FT SIGNAL 1..42
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02219"
FT CHAIN 43..680
FT /note="Type 3 secretion system secretin"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02219"
FT /id="PRO_5026405350"
FT DOMAIN 126..183
FT /note="NolW-like"
FT /evidence="ECO:0000259|Pfam:PF03958"
FT DOMAIN 196..337
FT /note="NolW-like"
FT /evidence="ECO:0000259|Pfam:PF03958"
FT DOMAIN 432..599
FT /note="Type II/III secretion system secretin-like"
FT /evidence="ECO:0000259|Pfam:PF00263"
FT REGION 605..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..662
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 680 AA; 72393 MW; 902F222422DB3AF1 CRC64;
MRQCVAPIRF QPRRLQRVAL AMCATALLTA SLCMTIAQPA RAADLRWRNK PFTIVANGKK
IGDFIRELAS SQGVTAVVDP KVDGVISGRF SGTPQQTLDT ICSTYGLTWY YDGSFLYVDP
ADQSQTQMIP IPPNAAGEIG RSLQAMQIPD KRYTLVINDR ANSVYVAGPR RYVELVRQAV
GSVGDPSANG AHADIRAFRL RYGWASDFTI NRSGKEVTVP GVATILRRLF GKGGGTNEPP
SSTPLGQAAR QVKLGSGLTI AVPRLDFPDI SGGARQGSYG GADSAAGGFS PFSNAGGGDT
LPQIVADPAI NAVIVRDLPE NMYRYQSLIN QLDERPRIVE INVTIIDINE DSLDSLGIDW
RLHTTHGDVQ IGNGQNPLNG NTQYNGAGNP PLTFGIGTSE TGQTGAFLPT GIALTASIGG
SLRNYLLTRV NALAQKGQAQ LRSKPKVLAL DNTEAILENL TQFYVQVQGY QDSSLYSVTT
GTSIKVTPMI VDEAIRNAAA VSGNPQSVMM SIDIQDGNIV PGQAVSNVPV IQQRNIVTKT
MIDEGKSLLI AGFNDDEVRL NKSGVPWLSD IPLIGNLFKY TDKSGNHMER FYLLTPRVVT
TASMYAPDGS PVNPGADGPA DPSGASMYRP PDNDIAVPLT PAPLPGTKFG PPALPPPPSD
AASRPVATTA GAPTHVDDHH
//
